Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200843 |
Resumo: | OBJECTIVES: This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease-ILD, emphysema or neither). METHODS: Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. P<0.05 was considered statistically significant. RESULTS: We enrolled 470 patients (1959 patient-year); 15.5 % (73/470) died during the follow-up. Compared with the SSc-ILD and other-SSc, in SSc-CPFE there was a higher prevalence of males, lower anticentromere antibodies prevalence and a more reduced pulmonary function (p<0.05). The Kaplan-Meier survival analysis demonstrates a significantly worse survival in patients with SSc-CPFE (HR vs SSc-ILD, vs SSc-emphysema and vs other-SSc, respectively 1.6 (CI 0.5 to 5.2), 1.6 (CI 0.7 to 3.8) and 2.8 (CI 1.2 to 6.6). CONCLUSIONS: CPFE increases the mortality risk in SSc along with a highly impaired lung function. These findings strengthen the importance to take into account emphysema in patients with SSc with ILD. |
id |
UFRGS-2_de43f4220eb65a951f9310928bbd5787 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/200843 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Ariani, AlaricoSilva, MárioBravi, ElenaParisi, SimoneSaracco, MartaDe Gennaro, FabioCaimmi, CristianGirelli, FrancescoDe Santis, MariaVolpe, AlessandroLumetti , FedericaHax, VanessaBredemeier, MarkusAlfieri, VeronicaSantilli, DanieleBodini, Flavio CesareLucchini, GianlucaMozzani, FlavioSeletti, ValeriaBacchini, EmanueleArrigoni, EugenioGiuggioli, DiliaChakr, Rafael Mendonça da SilvaIdolazzi, LucaBertorelli, GiuseppinaImberti, DavideMichieletti, EmanuelePaolazzi, GiuseppeFusaro, EnricoChetta, Alfredo AntonioScirè, Carlo AlbertoSverzellat, Nicola2019-10-19T03:56:34Z20192056-5933http://hdl.handle.net/10183/200843001099582OBJECTIVES: This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease-ILD, emphysema or neither). METHODS: Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. P<0.05 was considered statistically significant. RESULTS: We enrolled 470 patients (1959 patient-year); 15.5 % (73/470) died during the follow-up. Compared with the SSc-ILD and other-SSc, in SSc-CPFE there was a higher prevalence of males, lower anticentromere antibodies prevalence and a more reduced pulmonary function (p<0.05). The Kaplan-Meier survival analysis demonstrates a significantly worse survival in patients with SSc-CPFE (HR vs SSc-ILD, vs SSc-emphysema and vs other-SSc, respectively 1.6 (CI 0.5 to 5.2), 1.6 (CI 0.7 to 3.8) and 2.8 (CI 1.2 to 6.6). CONCLUSIONS: CPFE increases the mortality risk in SSc along with a highly impaired lung function. These findings strengthen the importance to take into account emphysema in patients with SSc with ILD.application/pdfengRMD Open. London. Vol. 5, no. 1 (Feb. 2019), p. e000820, 4 p.Fibrose pulmonar idiopáticaEnfisema pulmonarEscleroderma sistêmicoMortalidadeEstimativa de Kaplan-MeierDeclaração de HelsinkiOverall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001099582.pdf.txt001099582.pdf.txtExtracted Texttext/plain19388http://www.lume.ufrgs.br/bitstream/10183/200843/2/001099582.pdf.txt590044567714b774c223ff39b30efa65MD52ORIGINAL001099582.pdfTexto completo (inglês)application/pdf350839http://www.lume.ufrgs.br/bitstream/10183/200843/1/001099582.pdf03e3ca797750e369e145fc95464a6a5fMD5110183/2008432023-11-10 04:26:57.588423oai:www.lume.ufrgs.br:10183/200843Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-10T06:26:57Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
title |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
spellingShingle |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis Ariani, Alarico Fibrose pulmonar idiopática Enfisema pulmonar Escleroderma sistêmico Mortalidade Estimativa de Kaplan-Meier Declaração de Helsinki |
title_short |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
title_full |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
title_fullStr |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
title_full_unstemmed |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
title_sort |
Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis |
author |
Ariani, Alarico |
author_facet |
Ariani, Alarico Silva, Mário Bravi, Elena Parisi, Simone Saracco, Marta De Gennaro, Fabio Caimmi, Cristian Girelli, Francesco De Santis, Maria Volpe, Alessandro Lumetti , Federica Hax, Vanessa Bredemeier, Markus Alfieri, Veronica Santilli, Daniele Bodini, Flavio Cesare Lucchini, Gianluca Mozzani, Flavio Seletti, Valeria Bacchini, Emanuele Arrigoni, Eugenio Giuggioli, Dilia Chakr, Rafael Mendonça da Silva Idolazzi, Luca Bertorelli, Giuseppina Imberti, Davide Michieletti, Emanuele Paolazzi, Giuseppe Fusaro, Enrico Chetta, Alfredo Antonio Scirè, Carlo Alberto Sverzellat, Nicola |
author_role |
author |
author2 |
Silva, Mário Bravi, Elena Parisi, Simone Saracco, Marta De Gennaro, Fabio Caimmi, Cristian Girelli, Francesco De Santis, Maria Volpe, Alessandro Lumetti , Federica Hax, Vanessa Bredemeier, Markus Alfieri, Veronica Santilli, Daniele Bodini, Flavio Cesare Lucchini, Gianluca Mozzani, Flavio Seletti, Valeria Bacchini, Emanuele Arrigoni, Eugenio Giuggioli, Dilia Chakr, Rafael Mendonça da Silva Idolazzi, Luca Bertorelli, Giuseppina Imberti, Davide Michieletti, Emanuele Paolazzi, Giuseppe Fusaro, Enrico Chetta, Alfredo Antonio Scirè, Carlo Alberto Sverzellat, Nicola |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ariani, Alarico Silva, Mário Bravi, Elena Parisi, Simone Saracco, Marta De Gennaro, Fabio Caimmi, Cristian Girelli, Francesco De Santis, Maria Volpe, Alessandro Lumetti , Federica Hax, Vanessa Bredemeier, Markus Alfieri, Veronica Santilli, Daniele Bodini, Flavio Cesare Lucchini, Gianluca Mozzani, Flavio Seletti, Valeria Bacchini, Emanuele Arrigoni, Eugenio Giuggioli, Dilia Chakr, Rafael Mendonça da Silva Idolazzi, Luca Bertorelli, Giuseppina Imberti, Davide Michieletti, Emanuele Paolazzi, Giuseppe Fusaro, Enrico Chetta, Alfredo Antonio Scirè, Carlo Alberto Sverzellat, Nicola |
dc.subject.por.fl_str_mv |
Fibrose pulmonar idiopática Enfisema pulmonar Escleroderma sistêmico Mortalidade Estimativa de Kaplan-Meier Declaração de Helsinki |
topic |
Fibrose pulmonar idiopática Enfisema pulmonar Escleroderma sistêmico Mortalidade Estimativa de Kaplan-Meier Declaração de Helsinki |
description |
OBJECTIVES: This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease-ILD, emphysema or neither). METHODS: Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. P<0.05 was considered statistically significant. RESULTS: We enrolled 470 patients (1959 patient-year); 15.5 % (73/470) died during the follow-up. Compared with the SSc-ILD and other-SSc, in SSc-CPFE there was a higher prevalence of males, lower anticentromere antibodies prevalence and a more reduced pulmonary function (p<0.05). The Kaplan-Meier survival analysis demonstrates a significantly worse survival in patients with SSc-CPFE (HR vs SSc-ILD, vs SSc-emphysema and vs other-SSc, respectively 1.6 (CI 0.5 to 5.2), 1.6 (CI 0.7 to 3.8) and 2.8 (CI 1.2 to 6.6). CONCLUSIONS: CPFE increases the mortality risk in SSc along with a highly impaired lung function. These findings strengthen the importance to take into account emphysema in patients with SSc with ILD. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-10-19T03:56:34Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/200843 |
dc.identifier.issn.pt_BR.fl_str_mv |
2056-5933 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001099582 |
identifier_str_mv |
2056-5933 001099582 |
url |
http://hdl.handle.net/10183/200843 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
RMD Open. London. Vol. 5, no. 1 (Feb. 2019), p. e000820, 4 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/200843/2/001099582.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/200843/1/001099582.pdf |
bitstream.checksum.fl_str_mv |
590044567714b774c223ff39b30efa65 03e3ca797750e369e145fc95464a6a5f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224977024811008 |