Antifungal resistance on Sporothrix species : an overview
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/224632 |
Resumo: | Introduction The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this. Methodology Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Results The minimal inhibitory concentrations values based on the Clinical and Laboratory Standards Institute (CLSI) from eight references were classified according to the epidemiological cutoff values in wild-type or non-wild-type strains. In this way, nonwild- type S. schenckii and, mainly, S. brasiliensis isolates were recognized on itraconazole, amphotericin B, terbinafine, and voriconazole, which are strains that deserve more attention toward antifungal control, with a probable risk of mutation to antifungal resistance. Among the few reviewed studied on antifungal resistance, the melanin production capacity (DHN-melanin, L-DOPA melanin, and pyomelanin), the low genetic diversity due to the abnormal number of chromosomes, and the mutation in cytochrome P450 are some of the factors for developing resistance mechanism. Conclusions The emergence of Sporothrix species with in vitro antifungal resistance was evidenced and the possible mechanisms for resistance development may be due to the melanin production capacity, genetic diversity and mutations in cytochrome P450. Further studies should be carried out targeting gene expression for the development of antifungal resistance on Sporothrix species in order to prospect new therapeutic targets for human and veterinary use. |
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Waller, Stefanie BressanDalla Lana, Daiane FloresQuatrin, Priscilla MacielFerreira, Marcos Roberto AlvesFuentefria, Alexandre MeneghelloMezzari, Adelina2021-07-28T04:39:34Z20211517-8382http://hdl.handle.net/10183/224632001127065Introduction The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this. Methodology Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Results The minimal inhibitory concentrations values based on the Clinical and Laboratory Standards Institute (CLSI) from eight references were classified according to the epidemiological cutoff values in wild-type or non-wild-type strains. In this way, nonwild- type S. schenckii and, mainly, S. brasiliensis isolates were recognized on itraconazole, amphotericin B, terbinafine, and voriconazole, which are strains that deserve more attention toward antifungal control, with a probable risk of mutation to antifungal resistance. Among the few reviewed studied on antifungal resistance, the melanin production capacity (DHN-melanin, L-DOPA melanin, and pyomelanin), the low genetic diversity due to the abnormal number of chromosomes, and the mutation in cytochrome P450 are some of the factors for developing resistance mechanism. Conclusions The emergence of Sporothrix species with in vitro antifungal resistance was evidenced and the possible mechanisms for resistance development may be due to the melanin production capacity, genetic diversity and mutations in cytochrome P450. Further studies should be carried out targeting gene expression for the development of antifungal resistance on Sporothrix species in order to prospect new therapeutic targets for human and veterinary use.application/pdfengBrazilian journal of microbiology. São Paulo. Vol. 52, n. 1 (Mar. 2021), p. 73-80EsporotricoseFarmacorresistência fúngicaMelaninasVariação genéticaExpressão gênicaSporotrichosisSporothrix speciesAntifungal resistanceMelaninGenetic diversityMutationGene expressionAntifungal resistance on Sporothrix species : an overviewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001127065.pdf.txt001127065.pdf.txtExtracted Texttext/plain36639http://www.lume.ufrgs.br/bitstream/10183/224632/2/001127065.pdf.txt609a80b0fd226fd88222117f6f9ab3edMD52ORIGINAL001127065.pdfResumoapplication/pdf509246http://www.lume.ufrgs.br/bitstream/10183/224632/1/001127065.pdff353220c121dc2a2f379b45321cb2b1cMD5110183/2246322023-09-27 03:35:30.026957oai:www.lume.ufrgs.br:10183/224632Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-27T06:35:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Antifungal resistance on Sporothrix species : an overview |
title |
Antifungal resistance on Sporothrix species : an overview |
spellingShingle |
Antifungal resistance on Sporothrix species : an overview Waller, Stefanie Bressan Esporotricose Farmacorresistência fúngica Melaninas Variação genética Expressão gênica Sporotrichosis Sporothrix species Antifungal resistance Melanin Genetic diversity Mutation Gene expression |
title_short |
Antifungal resistance on Sporothrix species : an overview |
title_full |
Antifungal resistance on Sporothrix species : an overview |
title_fullStr |
Antifungal resistance on Sporothrix species : an overview |
title_full_unstemmed |
Antifungal resistance on Sporothrix species : an overview |
title_sort |
Antifungal resistance on Sporothrix species : an overview |
author |
Waller, Stefanie Bressan |
author_facet |
Waller, Stefanie Bressan Dalla Lana, Daiane Flores Quatrin, Priscilla Maciel Ferreira, Marcos Roberto Alves Fuentefria, Alexandre Meneghello Mezzari, Adelina |
author_role |
author |
author2 |
Dalla Lana, Daiane Flores Quatrin, Priscilla Maciel Ferreira, Marcos Roberto Alves Fuentefria, Alexandre Meneghello Mezzari, Adelina |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Waller, Stefanie Bressan Dalla Lana, Daiane Flores Quatrin, Priscilla Maciel Ferreira, Marcos Roberto Alves Fuentefria, Alexandre Meneghello Mezzari, Adelina |
dc.subject.por.fl_str_mv |
Esporotricose Farmacorresistência fúngica Melaninas Variação genética Expressão gênica |
topic |
Esporotricose Farmacorresistência fúngica Melaninas Variação genética Expressão gênica Sporotrichosis Sporothrix species Antifungal resistance Melanin Genetic diversity Mutation Gene expression |
dc.subject.eng.fl_str_mv |
Sporotrichosis Sporothrix species Antifungal resistance Melanin Genetic diversity Mutation Gene expression |
description |
Introduction The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this. Methodology Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Results The minimal inhibitory concentrations values based on the Clinical and Laboratory Standards Institute (CLSI) from eight references were classified according to the epidemiological cutoff values in wild-type or non-wild-type strains. In this way, nonwild- type S. schenckii and, mainly, S. brasiliensis isolates were recognized on itraconazole, amphotericin B, terbinafine, and voriconazole, which are strains that deserve more attention toward antifungal control, with a probable risk of mutation to antifungal resistance. Among the few reviewed studied on antifungal resistance, the melanin production capacity (DHN-melanin, L-DOPA melanin, and pyomelanin), the low genetic diversity due to the abnormal number of chromosomes, and the mutation in cytochrome P450 are some of the factors for developing resistance mechanism. Conclusions The emergence of Sporothrix species with in vitro antifungal resistance was evidenced and the possible mechanisms for resistance development may be due to the melanin production capacity, genetic diversity and mutations in cytochrome P450. Further studies should be carried out targeting gene expression for the development of antifungal resistance on Sporothrix species in order to prospect new therapeutic targets for human and veterinary use. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-07-28T04:39:34Z |
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2021 |
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1517-8382 |
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Brazilian journal of microbiology. São Paulo. Vol. 52, n. 1 (Mar. 2021), p. 73-80 |
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