Antifungal resistance on Sporothrix species : an overview

Detalhes bibliográficos
Autor(a) principal: Waller, Stefanie Bressan
Data de Publicação: 2021
Outros Autores: Dalla Lana, Daiane Flores, Quatrin, Priscilla Maciel, Ferreira, Marcos Roberto Alves, Fuentefria, Alexandre Meneghello, Mezzari, Adelina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/224632
Resumo: Introduction The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this. Methodology Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Results The minimal inhibitory concentrations values based on the Clinical and Laboratory Standards Institute (CLSI) from eight references were classified according to the epidemiological cutoff values in wild-type or non-wild-type strains. In this way, nonwild- type S. schenckii and, mainly, S. brasiliensis isolates were recognized on itraconazole, amphotericin B, terbinafine, and voriconazole, which are strains that deserve more attention toward antifungal control, with a probable risk of mutation to antifungal resistance. Among the few reviewed studied on antifungal resistance, the melanin production capacity (DHN-melanin, L-DOPA melanin, and pyomelanin), the low genetic diversity due to the abnormal number of chromosomes, and the mutation in cytochrome P450 are some of the factors for developing resistance mechanism. Conclusions The emergence of Sporothrix species with in vitro antifungal resistance was evidenced and the possible mechanisms for resistance development may be due to the melanin production capacity, genetic diversity and mutations in cytochrome P450. Further studies should be carried out targeting gene expression for the development of antifungal resistance on Sporothrix species in order to prospect new therapeutic targets for human and veterinary use.
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spelling Waller, Stefanie BressanDalla Lana, Daiane FloresQuatrin, Priscilla MacielFerreira, Marcos Roberto AlvesFuentefria, Alexandre MeneghelloMezzari, Adelina2021-07-28T04:39:34Z20211517-8382http://hdl.handle.net/10183/224632001127065Introduction The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this. Methodology Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Results The minimal inhibitory concentrations values based on the Clinical and Laboratory Standards Institute (CLSI) from eight references were classified according to the epidemiological cutoff values in wild-type or non-wild-type strains. In this way, nonwild- type S. schenckii and, mainly, S. brasiliensis isolates were recognized on itraconazole, amphotericin B, terbinafine, and voriconazole, which are strains that deserve more attention toward antifungal control, with a probable risk of mutation to antifungal resistance. Among the few reviewed studied on antifungal resistance, the melanin production capacity (DHN-melanin, L-DOPA melanin, and pyomelanin), the low genetic diversity due to the abnormal number of chromosomes, and the mutation in cytochrome P450 are some of the factors for developing resistance mechanism. Conclusions The emergence of Sporothrix species with in vitro antifungal resistance was evidenced and the possible mechanisms for resistance development may be due to the melanin production capacity, genetic diversity and mutations in cytochrome P450. Further studies should be carried out targeting gene expression for the development of antifungal resistance on Sporothrix species in order to prospect new therapeutic targets for human and veterinary use.application/pdfengBrazilian journal of microbiology. São Paulo. Vol. 52, n. 1 (Mar. 2021), p. 73-80EsporotricoseFarmacorresistência fúngicaMelaninasVariação genéticaExpressão gênicaSporotrichosisSporothrix speciesAntifungal resistanceMelaninGenetic diversityMutationGene expressionAntifungal resistance on Sporothrix species : an overviewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001127065.pdf.txt001127065.pdf.txtExtracted Texttext/plain36639http://www.lume.ufrgs.br/bitstream/10183/224632/2/001127065.pdf.txt609a80b0fd226fd88222117f6f9ab3edMD52ORIGINAL001127065.pdfResumoapplication/pdf509246http://www.lume.ufrgs.br/bitstream/10183/224632/1/001127065.pdff353220c121dc2a2f379b45321cb2b1cMD5110183/2246322023-09-27 03:35:30.026957oai:www.lume.ufrgs.br:10183/224632Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-27T06:35:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Antifungal resistance on Sporothrix species : an overview
title Antifungal resistance on Sporothrix species : an overview
spellingShingle Antifungal resistance on Sporothrix species : an overview
Waller, Stefanie Bressan
Esporotricose
Farmacorresistência fúngica
Melaninas
Variação genética
Expressão gênica
Sporotrichosis
Sporothrix species
Antifungal resistance
Melanin
Genetic diversity
Mutation
Gene expression
title_short Antifungal resistance on Sporothrix species : an overview
title_full Antifungal resistance on Sporothrix species : an overview
title_fullStr Antifungal resistance on Sporothrix species : an overview
title_full_unstemmed Antifungal resistance on Sporothrix species : an overview
title_sort Antifungal resistance on Sporothrix species : an overview
author Waller, Stefanie Bressan
author_facet Waller, Stefanie Bressan
Dalla Lana, Daiane Flores
Quatrin, Priscilla Maciel
Ferreira, Marcos Roberto Alves
Fuentefria, Alexandre Meneghello
Mezzari, Adelina
author_role author
author2 Dalla Lana, Daiane Flores
Quatrin, Priscilla Maciel
Ferreira, Marcos Roberto Alves
Fuentefria, Alexandre Meneghello
Mezzari, Adelina
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Waller, Stefanie Bressan
Dalla Lana, Daiane Flores
Quatrin, Priscilla Maciel
Ferreira, Marcos Roberto Alves
Fuentefria, Alexandre Meneghello
Mezzari, Adelina
dc.subject.por.fl_str_mv Esporotricose
Farmacorresistência fúngica
Melaninas
Variação genética
Expressão gênica
topic Esporotricose
Farmacorresistência fúngica
Melaninas
Variação genética
Expressão gênica
Sporotrichosis
Sporothrix species
Antifungal resistance
Melanin
Genetic diversity
Mutation
Gene expression
dc.subject.eng.fl_str_mv Sporotrichosis
Sporothrix species
Antifungal resistance
Melanin
Genetic diversity
Mutation
Gene expression
description Introduction The treatment of human and animal sporotrichosis is often performed with antifungal agents; however, the emergence of antifungal-resistant strains of Sporothrix species has been reported. We aimed to discuss the ability of Sporothrix species in developing resistance to the conventional antifungals and mechanisms for this. Methodology Published data on databases (PubMed, Science Direct, Google Scholar) were investigated using a combination of keywords from 2008 to 2019 by the StArt tool. Results The minimal inhibitory concentrations values based on the Clinical and Laboratory Standards Institute (CLSI) from eight references were classified according to the epidemiological cutoff values in wild-type or non-wild-type strains. In this way, nonwild- type S. schenckii and, mainly, S. brasiliensis isolates were recognized on itraconazole, amphotericin B, terbinafine, and voriconazole, which are strains that deserve more attention toward antifungal control, with a probable risk of mutation to antifungal resistance. Among the few reviewed studied on antifungal resistance, the melanin production capacity (DHN-melanin, L-DOPA melanin, and pyomelanin), the low genetic diversity due to the abnormal number of chromosomes, and the mutation in cytochrome P450 are some of the factors for developing resistance mechanism. Conclusions The emergence of Sporothrix species with in vitro antifungal resistance was evidenced and the possible mechanisms for resistance development may be due to the melanin production capacity, genetic diversity and mutations in cytochrome P450. Further studies should be carried out targeting gene expression for the development of antifungal resistance on Sporothrix species in order to prospect new therapeutic targets for human and veterinary use.
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of microbiology. São Paulo. Vol. 52, n. 1 (Mar. 2021), p. 73-80
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