Glycolytic pathway candidate markers in the prognosis of oral squamous cell carcinoma : a systematic review with meta-analysis

• Autor(a) principal: Mattos, Sérgio Edgar Campos de
• Data de Publicação: 2021
• Outros Autores: Diel, Leonardo Francisco, Bittencourt, Leonardo da Silva, Schnorr, Carlos Eduardo, Gonçalves, Fabiany da Costa, Bernardi, Lisiane, Lamers, Marcelo Lazzaron
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/219596
• topic: Carcinoma de células escamosas de cabeça e pescoço; Revisão sistemática; Metabolismo energético; Glicólise; Neoplasias bucais; Oral cancer; Survival; Prognosis; Disease-free survival; Energy metabolism

Molecular changes that affect mitochondrial glycolysis have been associated with the maintenance of tumor cells. Some metabolic factors have already been described as predictors of disease severity and outcomes. This systematic review was conducted to answer the question: Is the glycolytic pathway correlated with the prognosis of oral squamous cell carcinoma (OSCC)? A search strategy was developed to retrieve studies in English from PubMed, Scopus, and ISI Web of Science using keywords related to squamous cell carcinoma, survival, and glycolytic pathway, with no restriction of publication date. The search retrieved 1273 publications. After the titles and abstracts were analyzed, 27 studies met inclusion criteria. Studies were divided into groups according to two subtopics, glycolytic pathways and diagnosis, which describe the glycolytic profile of OSCC tumors. Several components of tumor energy metabolism found in this review are important predictors of survival of patients with OSCC.