Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21247 |
Resumo: | The 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene consists of the substitution of a guanine base by a thymine at the 894th nucleotide of the gene. An association of this polymorphism with acute coronary syndromes has been described, only when in combination with other polymorphisms of this gene. The aim of the present study was to search for an association between this polymorphism and unstable angina in a southern Brazilian population. In a case-control study, 156 patients (group 1 (N = 83): unstable angina, group 2 (N = 73): stable angina) were genotyped by PCR and digestion of the product. Univariate analysis demonstrated that the minimal luminal diameter and the degree of stenosis of the culprit lesion differed between groups (P = 0.006 and 0.005, respectively). In addition, the frequencies of the T allele and of the T allele carriers (combined TT and TG genotypes) were significantly higher in the group with unstable angina (41.6 vs 28.8%; P = 0.025, Pearson chisquare test, and 73.5 vs 45.2%; P = 0.001, Pearson chi-square test, respectively). Multivariate logistic regression showed that the frequency of the T allele carriers was the only variable with a predictive value for unstable angina, when controlled for the other variables (6.1 (95% CI = 2.55-14.43); P < 0.001). Thus, in a homogenous group of patients, the endothelial constitutive nitric oxide synthase 894G>T polymorphism was associated with unstable angina. We suggest that this polymorphism may be a genetic risk factor for unstable angina. |
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Iturry-Yamamoto, Germán RamiroMoriguchi, Emílio HideyukiZago, Alexandre do CantoAlho, Clarice SampaioZago, Alcides José2010-04-24T04:15:57Z20070100-879Xhttp://hdl.handle.net/10183/21247000731476The 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene consists of the substitution of a guanine base by a thymine at the 894th nucleotide of the gene. An association of this polymorphism with acute coronary syndromes has been described, only when in combination with other polymorphisms of this gene. The aim of the present study was to search for an association between this polymorphism and unstable angina in a southern Brazilian population. In a case-control study, 156 patients (group 1 (N = 83): unstable angina, group 2 (N = 73): stable angina) were genotyped by PCR and digestion of the product. Univariate analysis demonstrated that the minimal luminal diameter and the degree of stenosis of the culprit lesion differed between groups (P = 0.006 and 0.005, respectively). In addition, the frequencies of the T allele and of the T allele carriers (combined TT and TG genotypes) were significantly higher in the group with unstable angina (41.6 vs 28.8%; P = 0.025, Pearson chisquare test, and 73.5 vs 45.2%; P = 0.001, Pearson chi-square test, respectively). Multivariate logistic regression showed that the frequency of the T allele carriers was the only variable with a predictive value for unstable angina, when controlled for the other variables (6.1 (95% CI = 2.55-14.43); P < 0.001). Thus, in a homogenous group of patients, the endothelial constitutive nitric oxide synthase 894G>T polymorphism was associated with unstable angina. We suggest that this polymorphism may be a genetic risk factor for unstable angina.application/pdfengBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 40, no. 4 (2007), p. 475-483Óxido nítrico sintasePolimorfismo genéticoAngina instávelVasos coronáriosNitric oxide synthaseGenePolymorphismUnstable anginaCoronaryAssociation of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable anginaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000731476.pdf000731476.pdfTexto completo (inglês)application/pdf494018http://www.lume.ufrgs.br/bitstream/10183/21247/1/000731476.pdf985ef57c5a738fecec36549386ed3b90MD51TEXT000731476.pdf.txt000731476.pdf.txtExtracted Texttext/plain37371http://www.lume.ufrgs.br/bitstream/10183/21247/2/000731476.pdf.txt13ab5c216348e1c7324fa5fe4b0fe806MD52THUMBNAIL000731476.pdf.jpg000731476.pdf.jpgGenerated Thumbnailimage/jpeg1861http://www.lume.ufrgs.br/bitstream/10183/21247/3/000731476.pdf.jpg9a46748dd3fae2ebdb62162588c9aac0MD5310183/212472018-10-18 09:14:28.999oai:www.lume.ufrgs.br:10183/21247Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-18T12:14:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
title |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
spellingShingle |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina Iturry-Yamamoto, Germán Ramiro Óxido nítrico sintase Polimorfismo genético Angina instável Vasos coronários Nitric oxide synthase Gene Polymorphism Unstable angina Coronary |
title_short |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
title_full |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
title_fullStr |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
title_full_unstemmed |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
title_sort |
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina |
author |
Iturry-Yamamoto, Germán Ramiro |
author_facet |
Iturry-Yamamoto, Germán Ramiro Moriguchi, Emílio Hideyuki Zago, Alexandre do Canto Alho, Clarice Sampaio Zago, Alcides José |
author_role |
author |
author2 |
Moriguchi, Emílio Hideyuki Zago, Alexandre do Canto Alho, Clarice Sampaio Zago, Alcides José |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Iturry-Yamamoto, Germán Ramiro Moriguchi, Emílio Hideyuki Zago, Alexandre do Canto Alho, Clarice Sampaio Zago, Alcides José |
dc.subject.por.fl_str_mv |
Óxido nítrico sintase Polimorfismo genético Angina instável Vasos coronários |
topic |
Óxido nítrico sintase Polimorfismo genético Angina instável Vasos coronários Nitric oxide synthase Gene Polymorphism Unstable angina Coronary |
dc.subject.eng.fl_str_mv |
Nitric oxide synthase Gene Polymorphism Unstable angina Coronary |
description |
The 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene consists of the substitution of a guanine base by a thymine at the 894th nucleotide of the gene. An association of this polymorphism with acute coronary syndromes has been described, only when in combination with other polymorphisms of this gene. The aim of the present study was to search for an association between this polymorphism and unstable angina in a southern Brazilian population. In a case-control study, 156 patients (group 1 (N = 83): unstable angina, group 2 (N = 73): stable angina) were genotyped by PCR and digestion of the product. Univariate analysis demonstrated that the minimal luminal diameter and the degree of stenosis of the culprit lesion differed between groups (P = 0.006 and 0.005, respectively). In addition, the frequencies of the T allele and of the T allele carriers (combined TT and TG genotypes) were significantly higher in the group with unstable angina (41.6 vs 28.8%; P = 0.025, Pearson chisquare test, and 73.5 vs 45.2%; P = 0.001, Pearson chi-square test, respectively). Multivariate logistic regression showed that the frequency of the T allele carriers was the only variable with a predictive value for unstable angina, when controlled for the other variables (6.1 (95% CI = 2.55-14.43); P < 0.001). Thus, in a homogenous group of patients, the endothelial constitutive nitric oxide synthase 894G>T polymorphism was associated with unstable angina. We suggest that this polymorphism may be a genetic risk factor for unstable angina. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:57Z |
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0100-879X |
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000731476 |
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dc.language.iso.fl_str_mv |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 40, no. 4 (2007), p. 475-483 |
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