Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/195669 |
Resumo: | Abstract: Background: Sentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this procedure. Objective: To evaluate the association between the presence of tumor-infiltrating lymphocytes and lymph node metastases caused by thin primary cutaneous melanoma. Methods: Cross-sectional study with 137 records of thin invasive primary cutaneous melanoma submitted to sentinel lymph node biopsy from 2003 to 2015. The clinical variables considered were age, sex and topography of the lesion. The histopathological variables assessed were: tumor-infiltrating lymphocytes, melanoma subtype, Breslow thickness, Clark levels, number of mitoses per mm², ulceration, regression and satellitosis. Univariate analyzes and logistic regression tests were performed as well the odds ratio and statistical relevance was considered when p <0.05. Results: Among the 137 cases of thin primary cutaneous melanoma submitted to sentinel lymph node biopsy, 10 (7.3%) had metastatic involvement. Ulceration on histopathology was positively associated with the presence of metastatic lymph node, with odds ratio =12.8 (2.77-59.4 95% CI, p=0.001). The presence of moderate/marked tumor-infiltrating lymphocytes was shown to be a protective factor for the presence of metastatic lymph node, with OR=0.20 (0.05-0.72 95% CI, p=0.014). The other variables - clinical and histopathological - were not associated with the outcome. Study limitations: The relatively small number of positive sentinel lymph node biopsy may explain such an expressive association of ulceration with metastatization. Conclusions: In patients with thin invasive primary cutaneous melanoma, few or absent tumor-infiltrating lymphocytes, as well as ulceration, represent independent risk factors for lymph node metastasis. |
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Santos, Fernando de Marco dosSilva, Felipe Correa daPedron, JuliaFurian, RoqueFortes, Cristina DeppermannBonamigo, Renan Rangel2019-06-12T02:32:05Z20190365-0596http://hdl.handle.net/10183/195669001089508Abstract: Background: Sentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this procedure. Objective: To evaluate the association between the presence of tumor-infiltrating lymphocytes and lymph node metastases caused by thin primary cutaneous melanoma. Methods: Cross-sectional study with 137 records of thin invasive primary cutaneous melanoma submitted to sentinel lymph node biopsy from 2003 to 2015. The clinical variables considered were age, sex and topography of the lesion. The histopathological variables assessed were: tumor-infiltrating lymphocytes, melanoma subtype, Breslow thickness, Clark levels, number of mitoses per mm², ulceration, regression and satellitosis. Univariate analyzes and logistic regression tests were performed as well the odds ratio and statistical relevance was considered when p <0.05. Results: Among the 137 cases of thin primary cutaneous melanoma submitted to sentinel lymph node biopsy, 10 (7.3%) had metastatic involvement. Ulceration on histopathology was positively associated with the presence of metastatic lymph node, with odds ratio =12.8 (2.77-59.4 95% CI, p=0.001). The presence of moderate/marked tumor-infiltrating lymphocytes was shown to be a protective factor for the presence of metastatic lymph node, with OR=0.20 (0.05-0.72 95% CI, p=0.014). The other variables - clinical and histopathological - were not associated with the outcome. Study limitations: The relatively small number of positive sentinel lymph node biopsy may explain such an expressive association of ulceration with metastatization. Conclusions: In patients with thin invasive primary cutaneous melanoma, few or absent tumor-infiltrating lymphocytes, as well as ulceration, represent independent risk factors for lymph node metastasis.application/pdfengAnais brasileiros de dermatologia. vol. 94, n. 1 (jan./fev. 2019), p. 47-51.MelanomaBiópsia de linfonodo sentinelaLinfócitos do interstício tumoralLymphocytestumor-infiltratingMedical oncologyMelanomaSentinel lymph node biopsyAssociation between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanomainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001089508.pdf.txt001089508.pdf.txtExtracted Texttext/plain23942http://www.lume.ufrgs.br/bitstream/10183/195669/2/001089508.pdf.txt4886bb7b387d3eed25e6a2768f13d4a9MD52ORIGINAL001089508.pdfTexto completo (inglês)application/pdf295814http://www.lume.ufrgs.br/bitstream/10183/195669/1/001089508.pdf40c58066a112ae4782b44f888318d1adMD5110183/1956692019-06-13 02:31:24.44385oai:www.lume.ufrgs.br:10183/195669Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-13T05:31:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
title |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
spellingShingle |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma Santos, Fernando de Marco dos Melanoma Biópsia de linfonodo sentinela Linfócitos do interstício tumoral Lymphocytes tumor-infiltrating Medical oncology Melanoma Sentinel lymph node biopsy |
title_short |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
title_full |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
title_fullStr |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
title_full_unstemmed |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
title_sort |
Association between tumor-infiltrating limphocytes and sentinel lymph node positivity in thin melanoma |
author |
Santos, Fernando de Marco dos |
author_facet |
Santos, Fernando de Marco dos Silva, Felipe Correa da Pedron, Julia Furian, Roque Fortes, Cristina Deppermann Bonamigo, Renan Rangel |
author_role |
author |
author2 |
Silva, Felipe Correa da Pedron, Julia Furian, Roque Fortes, Cristina Deppermann Bonamigo, Renan Rangel |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Fernando de Marco dos Silva, Felipe Correa da Pedron, Julia Furian, Roque Fortes, Cristina Deppermann Bonamigo, Renan Rangel |
dc.subject.por.fl_str_mv |
Melanoma Biópsia de linfonodo sentinela Linfócitos do interstício tumoral |
topic |
Melanoma Biópsia de linfonodo sentinela Linfócitos do interstício tumoral Lymphocytes tumor-infiltrating Medical oncology Melanoma Sentinel lymph node biopsy |
dc.subject.eng.fl_str_mv |
Lymphocytes tumor-infiltrating Medical oncology Melanoma Sentinel lymph node biopsy |
description |
Abstract: Background: Sentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this procedure. Objective: To evaluate the association between the presence of tumor-infiltrating lymphocytes and lymph node metastases caused by thin primary cutaneous melanoma. Methods: Cross-sectional study with 137 records of thin invasive primary cutaneous melanoma submitted to sentinel lymph node biopsy from 2003 to 2015. The clinical variables considered were age, sex and topography of the lesion. The histopathological variables assessed were: tumor-infiltrating lymphocytes, melanoma subtype, Breslow thickness, Clark levels, number of mitoses per mm², ulceration, regression and satellitosis. Univariate analyzes and logistic regression tests were performed as well the odds ratio and statistical relevance was considered when p <0.05. Results: Among the 137 cases of thin primary cutaneous melanoma submitted to sentinel lymph node biopsy, 10 (7.3%) had metastatic involvement. Ulceration on histopathology was positively associated with the presence of metastatic lymph node, with odds ratio =12.8 (2.77-59.4 95% CI, p=0.001). The presence of moderate/marked tumor-infiltrating lymphocytes was shown to be a protective factor for the presence of metastatic lymph node, with OR=0.20 (0.05-0.72 95% CI, p=0.014). The other variables - clinical and histopathological - were not associated with the outcome. Study limitations: The relatively small number of positive sentinel lymph node biopsy may explain such an expressive association of ulceration with metastatization. Conclusions: In patients with thin invasive primary cutaneous melanoma, few or absent tumor-infiltrating lymphocytes, as well as ulceration, represent independent risk factors for lymph node metastasis. |
publishDate |
2019 |
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2019-06-12T02:32:05Z |
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2019 |
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publishedVersion |
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http://hdl.handle.net/10183/195669 |
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0365-0596 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001089508 |
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http://hdl.handle.net/10183/195669 |
dc.language.iso.fl_str_mv |
eng |
language |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Anais brasileiros de dermatologia. vol. 94, n. 1 (jan./fev. 2019), p. 47-51. |
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openAccess |
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