Bipolar disorder : an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation

• Autor(a) principal: Reckziegel, Ramiro de Freitas Xavier
• Data de Publicação: 2022
• Outros Autores: Czepielewski, Letícia Sanguinetti, Ponte, Francisco Diego Rabelo da, Feiten, Jacson Gabriel, Remus, Isadora Bosini, Goi, Pedro Domingues, Sulzbach, Miréia Fortes Vianna, Massuda, Raffael, Macêdo, Danielle, Lucena, David Freitas de, Gama, Clarissa Severino
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/255644
• topic: Transtorno bipolar; Giro do cíngulo; Obesidade; Bipolar disorder; Obesity; White matter; Diffusion tensor imaging

Objective: To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods: The sample consisted of 101 individuals (BD n = 35 and CTR n = 66). Regions of interest (ROI) were defined using a machine learning approach. For each ROI, a regression model tested the association between FA and BMI, controlling for covariates. Peripheral CRP levels were assayed, correlated with BMI, and included in a mediation analysis. Results: BMI predicted the FA of the right cingulate gyrus in BD (AdjR² = 0.312 F(3) = 5.537 p = 0.004; β = -0.340 p = 0.034), while there was no association in CTR. There was an interaction effect between BMI and BD diagnosis (F(5) = 3.5857 p = 0.012; Fchange = 0.227 AdjR² = 0.093; β = -1.093, p = 0.048). Furthermore, there was a positive correlation between BMI and CRP in both groups (AdjR² = 0.170 F(3) = 7.337 p < 0.001; β = 0.364 p = 0.001), but it did not act as a mediator of the effect on FA. Conclusion: Higher BMI is associated with right cingulate microstructure in BD, but not in CTR, and this effect could not be explained by inflammatory mediation alone.