Interference of propylene glycol with the hole-board test

Detalhes bibliográficos
Autor(a) principal: Silva, Adriana Lourenço da
Data de Publicação: 2001
Outros Autores: Elisabetsky, Elaine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21203
Resumo: Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the headdipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent.
id UFRGS-2_f18c263a702b316d14d96838bcdbe134
oai_identifier_str oai:www.lume.ufrgs.br:10183/21203
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Silva, Adriana Lourenço daElisabetsky, Elaine2010-04-24T04:15:42Z20010100-879Xhttp://hdl.handle.net/10183/21203000576295Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the headdipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent.application/pdfengRevista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 4 (Apr. 2001), p. 545-547Farmacologia clínicaScreeningAnxiolytic drugsPropylene glycolDiazepamSolventsHole-boardInterference of propylene glycol with the hole-board testinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000576295.pdf000576295.pdfTexto completo (inglês)application/pdf124699http://www.lume.ufrgs.br/bitstream/10183/21203/1/000576295.pdf68e08e056bde3a1c2b1ff3459428c91cMD51TEXT000576295.pdf.txt000576295.pdf.txtExtracted Texttext/plain10665http://www.lume.ufrgs.br/bitstream/10183/21203/2/000576295.pdf.txta4fd58f675fd69ee27b8e23aec469b92MD52THUMBNAIL000576295.pdf.jpg000576295.pdf.jpgGenerated Thumbnailimage/jpeg1604http://www.lume.ufrgs.br/bitstream/10183/21203/3/000576295.pdf.jpgaacb3d51f65b6b2bf674f0a3b12d7e84MD5310183/212032019-01-11 04:08:31.98782oai:www.lume.ufrgs.br:10183/21203Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-11T06:08:31Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Interference of propylene glycol with the hole-board test
title Interference of propylene glycol with the hole-board test
spellingShingle Interference of propylene glycol with the hole-board test
Silva, Adriana Lourenço da
Farmacologia clínica
Screening
Anxiolytic drugs
Propylene glycol
Diazepam
Solvents
Hole-board
title_short Interference of propylene glycol with the hole-board test
title_full Interference of propylene glycol with the hole-board test
title_fullStr Interference of propylene glycol with the hole-board test
title_full_unstemmed Interference of propylene glycol with the hole-board test
title_sort Interference of propylene glycol with the hole-board test
author Silva, Adriana Lourenço da
author_facet Silva, Adriana Lourenço da
Elisabetsky, Elaine
author_role author
author2 Elisabetsky, Elaine
author2_role author
dc.contributor.author.fl_str_mv Silva, Adriana Lourenço da
Elisabetsky, Elaine
dc.subject.por.fl_str_mv Farmacologia clínica
topic Farmacologia clínica
Screening
Anxiolytic drugs
Propylene glycol
Diazepam
Solvents
Hole-board
dc.subject.eng.fl_str_mv Screening
Anxiolytic drugs
Propylene glycol
Diazepam
Solvents
Hole-board
description Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the headdipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P<0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P<0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2010-04-24T04:15:42Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/21203
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.nrb.pt_BR.fl_str_mv 000576295
identifier_str_mv 0100-879X
000576295
url http://hdl.handle.net/10183/21203
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Revista brasileira de pesquisas médicas e biológicas = Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 4 (Apr. 2001), p. 545-547
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/21203/1/000576295.pdf
http://www.lume.ufrgs.br/bitstream/10183/21203/2/000576295.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/21203/3/000576295.pdf.jpg
bitstream.checksum.fl_str_mv 68e08e056bde3a1c2b1ff3459428c91c
a4fd58f675fd69ee27b8e23aec469b92
aacb3d51f65b6b2bf674f0a3b12d7e84
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1815447407233597440

Registros relacionados