LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules

Detalhes bibliográficos
Autor(a) principal: Dimer, Frantiescoli Anversa
Data de Publicação: 2014
Outros Autores: Pigatto, Maiara Cássia, Pohlmann, Adriana Raffin, Dalla Costa, Teresa Cristina Tavares, Guterres, Silvia Stanisçuaski
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/107191
Resumo: In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL) to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges of 10–1000 ng mL−1. Extraction recoveries, stability, and validation parameters were evaluated. Results were within the acceptable limits of international guidelines. A significant decrease in clearance led to a significant 2.26-times increase in AUC0–6h of olanzapine-loaded lipid-core nanocapsules compared with free-olanzapine.
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spelling Dimer, Frantiescoli AnversaPigatto, Maiara CássiaPohlmann, Adriana RaffinDalla Costa, Teresa Cristina TavaresGuterres, Silvia Stanisçuaski2014-11-20T02:16:01Z20140100-4042http://hdl.handle.net/10183/107191000940408In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL) to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges of 10–1000 ng mL−1. Extraction recoveries, stability, and validation parameters were evaluated. Results were within the acceptable limits of international guidelines. A significant decrease in clearance led to a significant 2.26-times increase in AUC0–6h of olanzapine-loaded lipid-core nanocapsules compared with free-olanzapine.application/pdfporQuímica nova. São Paulo. Vol. 37, n. 8 (2014), p. 1371-1376FarmáciaNanocápsulasCromatografia liquidaEspectrometria de massaOlanzapinaAntipsicóticosPharmacokineticsLC-MS/MSLipid-core nanocapsulesLC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsulesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000940408.pdf000940408.pdfTexto completo (inglês)application/pdf298762http://www.lume.ufrgs.br/bitstream/10183/107191/1/000940408.pdf250a28c95dd3fac06f4b779b39f9c84dMD51TEXT000940408.pdf.txt000940408.pdf.txtExtracted Texttext/plain30489http://www.lume.ufrgs.br/bitstream/10183/107191/2/000940408.pdf.txtdb093bbe0f4c996c06b9c3b8d32a55fdMD52THUMBNAIL000940408.pdf.jpg000940408.pdf.jpgGenerated Thumbnailimage/jpeg1941http://www.lume.ufrgs.br/bitstream/10183/107191/3/000940408.pdf.jpg22926ec363e5f30931053b1053c49b11MD5310183/1071912020-02-20 04:15:57.120262oai:www.lume.ufrgs.br:10183/107191Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2020-02-20T07:15:57Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
title LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
spellingShingle LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
Dimer, Frantiescoli Anversa
Farmácia
Nanocápsulas
Cromatografia liquida
Espectrometria de massa
Olanzapina
Antipsicóticos
Pharmacokinetics
LC-MS/MS
Lipid-core nanocapsules
title_short LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
title_full LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
title_fullStr LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
title_full_unstemmed LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
title_sort LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
author Dimer, Frantiescoli Anversa
author_facet Dimer, Frantiescoli Anversa
Pigatto, Maiara Cássia
Pohlmann, Adriana Raffin
Dalla Costa, Teresa Cristina Tavares
Guterres, Silvia Stanisçuaski
author_role author
author2 Pigatto, Maiara Cássia
Pohlmann, Adriana Raffin
Dalla Costa, Teresa Cristina Tavares
Guterres, Silvia Stanisçuaski
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Dimer, Frantiescoli Anversa
Pigatto, Maiara Cássia
Pohlmann, Adriana Raffin
Dalla Costa, Teresa Cristina Tavares
Guterres, Silvia Stanisçuaski
dc.subject.por.fl_str_mv Farmácia
Nanocápsulas
Cromatografia liquida
Espectrometria de massa
Olanzapina
Antipsicóticos
topic Farmácia
Nanocápsulas
Cromatografia liquida
Espectrometria de massa
Olanzapina
Antipsicóticos
Pharmacokinetics
LC-MS/MS
Lipid-core nanocapsules
dc.subject.eng.fl_str_mv Pharmacokinetics
LC-MS/MS
Lipid-core nanocapsules
description In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL) to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges of 10–1000 ng mL−1. Extraction recoveries, stability, and validation parameters were evaluated. Results were within the acceptable limits of international guidelines. A significant decrease in clearance led to a significant 2.26-times increase in AUC0–6h of olanzapine-loaded lipid-core nanocapsules compared with free-olanzapine.
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-11-20T02:16:01Z
dc.date.issued.fl_str_mv 2014
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/107191
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000940408
identifier_str_mv 0100-4042
000940408
url http://hdl.handle.net/10183/107191
dc.language.iso.fl_str_mv por
language por
dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 37, n. 8 (2014), p. 1371-1376
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/107191/1/000940408.pdf
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