Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety)
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/188775 |
Resumo: | High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects. |
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Lacerda, Denise dos SantosAlmeida, Mariana Garbin deTeixeira, Cláudia da SilvaJesus, Alyne Gonçalves dePereira Junior, Edison da SilvaBock, Patricia MartinsHenriques, João Antonio PêgasGomez, RosaneDani, CarolineFunchal, Cláudia da Silva2019-02-14T02:32:47Z20182306-5710http://hdl.handle.net/10183/188775001085993High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects.application/pdfengBeverages. Basel. Vol. 4, no. 4 (2018), 100, 13 p.Dieta hiperlipidicaGorduras na dietaAntioxidantesSuco de uvaGrape juiceAntioxidantsHigh-fat dietProtectionObesityBiochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety)Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001085993.pdf.txt001085993.pdf.txtExtracted Texttext/plain52456http://www.lume.ufrgs.br/bitstream/10183/188775/2/001085993.pdf.txtfc5792eaeb9b06145e50b5ebabf32c83MD52ORIGINAL001085993.pdfTexto completo (inglês)application/pdf1318274http://www.lume.ufrgs.br/bitstream/10183/188775/1/001085993.pdfeebbad8a3b68f8b157543b2114baaeb0MD5110183/1887752021-03-09 04:35:48.292834oai:www.lume.ufrgs.br:10183/188775Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-03-09T07:35:48Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
title |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
spellingShingle |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) Lacerda, Denise dos Santos Dieta hiperlipidica Gorduras na dieta Antioxidantes Suco de uva Grape juice Antioxidants High-fat diet Protection Obesity |
title_short |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
title_full |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
title_fullStr |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
title_full_unstemmed |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
title_sort |
Biochemical and physiological parameters in rats fed with high-fat diet : the protective effect of chronic treatment with purple grape juice (bordo variety) |
author |
Lacerda, Denise dos Santos |
author_facet |
Lacerda, Denise dos Santos Almeida, Mariana Garbin de Teixeira, Cláudia da Silva Jesus, Alyne Gonçalves de Pereira Junior, Edison da Silva Bock, Patricia Martins Henriques, João Antonio Pêgas Gomez, Rosane Dani, Caroline Funchal, Cláudia da Silva |
author_role |
author |
author2 |
Almeida, Mariana Garbin de Teixeira, Cláudia da Silva Jesus, Alyne Gonçalves de Pereira Junior, Edison da Silva Bock, Patricia Martins Henriques, João Antonio Pêgas Gomez, Rosane Dani, Caroline Funchal, Cláudia da Silva |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lacerda, Denise dos Santos Almeida, Mariana Garbin de Teixeira, Cláudia da Silva Jesus, Alyne Gonçalves de Pereira Junior, Edison da Silva Bock, Patricia Martins Henriques, João Antonio Pêgas Gomez, Rosane Dani, Caroline Funchal, Cláudia da Silva |
dc.subject.por.fl_str_mv |
Dieta hiperlipidica Gorduras na dieta Antioxidantes Suco de uva |
topic |
Dieta hiperlipidica Gorduras na dieta Antioxidantes Suco de uva Grape juice Antioxidants High-fat diet Protection Obesity |
dc.subject.eng.fl_str_mv |
Grape juice Antioxidants High-fat diet Protection Obesity |
description |
High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-02-14T02:32:47Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/188775 |
dc.identifier.issn.pt_BR.fl_str_mv |
2306-5710 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001085993 |
identifier_str_mv |
2306-5710 001085993 |
url |
http://hdl.handle.net/10183/188775 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Beverages. Basel. Vol. 4, no. 4 (2018), 100, 13 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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Repositório Institucional da UFRGS |
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