Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence

Detalhes bibliográficos
Autor(a) principal: Rebello,André Soares
Data de Publicação: 2011
Outros Autores: Moura-Neto,Rodrigo, Carvalho,Maria da Glória da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852011000100002
Resumo: OBJECTIVE: The aim of this study was to investigate the polymorphism Ile349Val of the enzyme alcohol dehydrogenase ADH1C gene among individuals with alcohol dependence syndrome (ADS) attending Alcoholics Anonymous (AA) meetings. METHODS: A total of 120 subjects residing in Rio de Janeiro city participated in this study. Subjects were divided into two groups: a group consisting of 54 individuals from the ADS group and 66 individuals that declared not having any alcohol dependence (control group). DNA was extracted from mouth epithelial cells by phenol-chloroform method and further submitted to amplification by polymerase chain reaction (PCR). RESULTS: Our results did not show differences between the genotypes of control individuals and ADS subjects. Nevertheless, we found increased rates of alcoholism in families of ADS subjects as compared to controls. CONCLUSIONS: Our results did not show any genotype difference on the ADH1C gene when control and AA genotypes are compared.
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spelling Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependenceAlcohol dehydrogenasepolymorphismchemical dependencealcoholismOBJECTIVE: The aim of this study was to investigate the polymorphism Ile349Val of the enzyme alcohol dehydrogenase ADH1C gene among individuals with alcohol dependence syndrome (ADS) attending Alcoholics Anonymous (AA) meetings. METHODS: A total of 120 subjects residing in Rio de Janeiro city participated in this study. Subjects were divided into two groups: a group consisting of 54 individuals from the ADS group and 66 individuals that declared not having any alcohol dependence (control group). DNA was extracted from mouth epithelial cells by phenol-chloroform method and further submitted to amplification by polymerase chain reaction (PCR). RESULTS: Our results did not show differences between the genotypes of control individuals and ADS subjects. Nevertheless, we found increased rates of alcoholism in families of ADS subjects as compared to controls. CONCLUSIONS: Our results did not show any genotype difference on the ADH1C gene when control and AA genotypes are compared.Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852011000100002Jornal Brasileiro de Psiquiatria v.60 n.1 2011reponame:Jornal Brasileiro de Psiquiatria (Online)instname:Universidade Federal do Rio de Janeiro (UFRJ)instacron:UFRJ10.1590/S0047-20852011000100002info:eu-repo/semantics/openAccessRebello,André SoaresMoura-Neto,RodrigoCarvalho,Maria da Glória da Costaeng2011-03-31T00:00:00Zoai:scielo:S0047-20852011000100002Revistahttp://portalrev.enfermagem.bvs.br/index.php?issn=0047-2085&lang=ptONGhttps://old.scielo.br/oai/scielo-oai.php||editora@ipub.ufrj.br1982-02080047-2085opendoar:2011-03-31T00:00Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ)false
dc.title.none.fl_str_mv Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
title Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
spellingShingle Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
Rebello,André Soares
Alcohol dehydrogenase
polymorphism
chemical dependence
alcoholism
title_short Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
title_full Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
title_fullStr Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
title_full_unstemmed Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
title_sort Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence
author Rebello,André Soares
author_facet Rebello,André Soares
Moura-Neto,Rodrigo
Carvalho,Maria da Glória da Costa
author_role author
author2 Moura-Neto,Rodrigo
Carvalho,Maria da Glória da Costa
author2_role author
author
dc.contributor.author.fl_str_mv Rebello,André Soares
Moura-Neto,Rodrigo
Carvalho,Maria da Glória da Costa
dc.subject.por.fl_str_mv Alcohol dehydrogenase
polymorphism
chemical dependence
alcoholism
topic Alcohol dehydrogenase
polymorphism
chemical dependence
alcoholism
description OBJECTIVE: The aim of this study was to investigate the polymorphism Ile349Val of the enzyme alcohol dehydrogenase ADH1C gene among individuals with alcohol dependence syndrome (ADS) attending Alcoholics Anonymous (AA) meetings. METHODS: A total of 120 subjects residing in Rio de Janeiro city participated in this study. Subjects were divided into two groups: a group consisting of 54 individuals from the ADS group and 66 individuals that declared not having any alcohol dependence (control group). DNA was extracted from mouth epithelial cells by phenol-chloroform method and further submitted to amplification by polymerase chain reaction (PCR). RESULTS: Our results did not show differences between the genotypes of control individuals and ADS subjects. Nevertheless, we found increased rates of alcoholism in families of ADS subjects as compared to controls. CONCLUSIONS: Our results did not show any genotype difference on the ADH1C gene when control and AA genotypes are compared.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852011000100002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852011000100002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0047-20852011000100002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
publisher.none.fl_str_mv Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
dc.source.none.fl_str_mv Jornal Brasileiro de Psiquiatria v.60 n.1 2011
reponame:Jornal Brasileiro de Psiquiatria (Online)
instname:Universidade Federal do Rio de Janeiro (UFRJ)
instacron:UFRJ
instname_str Universidade Federal do Rio de Janeiro (UFRJ)
instacron_str UFRJ
institution UFRJ
reponame_str Jornal Brasileiro de Psiquiatria (Online)
collection Jornal Brasileiro de Psiquiatria (Online)
repository.name.fl_str_mv Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ)
repository.mail.fl_str_mv ||editora@ipub.ufrj.br
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