Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Ciência Plural |
Texto Completo: | https://periodicos.ufrn.br/rcp/article/view/30628 |
Resumo: | Introduction: Even in health emergencies, when experimental therapies are used, it is important to regard the medication safety and efficacy, and the analysis of medical prescriptions is one of the ways to monitor safety aspects. Objective: quantify and classify Potential Drug Interactions (PDIs) with Hydroxychloroquine (HCQ) according to risk in prescriptions for patients with COVID-19 in use of HCQ admitted to an Intensive Care Unit (ICU) of a Teaching Hospital. Methodology: This cross-sectional study was based on the analysis of 162 prescriptions from 38 patients with COVID-19 using HCQ in an ICU. Micromedex® and UpToDate® were the databases to support clinical management used to establish PDI. Results: The mean number of days of hospitalization was 16.1 ± 14.0 and the mean number of days using HCQ was 4.26 ± 1.74. 87.14% of prescriptions presented PDI and the most common was between HCQ and azithromycin. 77.77% of prescriptions had at least one PDI between drugs that prolong the QT interval. Conclusions: Considering the risks of exposing critical patients to drug interactions, this study demonstrates the need to strengthen the culture of monitoring drug safety and efficacy parameters in health institutions, even in experimental therapies with utilization off-label drugs indication, to minimize risks and expand possible benefits. Keywords: COVID-19. Hydroxychloroquine. Intensive Care Unit. |
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Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit Introduction: Even in health emergencies, when experimental therapies are used, it is important to regard the medication safety and efficacy, and the analysis of medical prescriptions is one of the ways to monitor safety aspects. Objective: quantify and cANÁLISE DAS PRESCRIÇÕES DE PACIENTES COM COVID-19 EM USO DE HIDROXICLOROQUINA EM UMA UNIDADE DE TERAPIA INTENSIVAIntroduction: Even in health emergencies, when experimental therapies are used, it is important to regard the medication safety and efficacy, and the analysis of medical prescriptions is one of the ways to monitor safety aspects. Objective: quantify and classify Potential Drug Interactions (PDIs) with Hydroxychloroquine (HCQ) according to risk in prescriptions for patients with COVID-19 in use of HCQ admitted to an Intensive Care Unit (ICU) of a Teaching Hospital. Methodology: This cross-sectional study was based on the analysis of 162 prescriptions from 38 patients with COVID-19 using HCQ in an ICU. Micromedex® and UpToDate® were the databases to support clinical management used to establish PDI. Results: The mean number of days of hospitalization was 16.1 ± 14.0 and the mean number of days using HCQ was 4.26 ± 1.74. 87.14% of prescriptions presented PDI and the most common was between HCQ and azithromycin. 77.77% of prescriptions had at least one PDI between drugs that prolong the QT interval. Conclusions: Considering the risks of exposing critical patients to drug interactions, this study demonstrates the need to strengthen the culture of monitoring drug safety and efficacy parameters in health institutions, even in experimental therapies with utilization off-label drugs indication, to minimize risks and expand possible benefits. Keywords: COVID-19. Hydroxychloroquine. Intensive Care Unit.Introducción: Incluso en emergencias sanitarias, cuando se utilizan terapias experimentales, es importante valorar la seguridad y eficacia en el uso de los medicamentos, y el análisis de las prescripciones es una de las formas de monitorear aspectos de seguridad. Objetivo: Cuantificar y clasificar las Interacciones Potenciales de Medicamentos (PMI) con HCQ según el riesgo, identificar el perfil de Medicamentos Potencialmente Peligrosos (PMP) en prescripciones de pacientes con COVID-19 usando Hidroxicloroquina (HCQ) ingresados en una Unidad de Cuidados Intensivos (UCI) de un Hospital Universitario. Metodología: Este estudio transversal se basó en el análisis de 162 prescripciones de 38 pacientes. Micromedex®️ y UpToDate®️ fueron las bases de datos de apoyo a la gestión clínica utilizadas para establecer los PDI. Resultados: El promedio de días de hospitalización fue de 16,1 ± 14,0 y el promedio de días con HCQ fue de 4,26 ± 1,74. El 87,14% de las prescripciones presentaron PDI y la más frecuente fue entre HCQ y azitromicina. El 77,77% de las prescripciones tenían al menos un PDI entre fármacos que prolongan el intervalo QT. Conclusiones: Ante los riesgos de exponer pacientes críticos a interacciones medicamentosas, este estudio demuestra la necesidad de fortalecer la cultura de monitoreo de parámetros de seguridad y eficacia en el uso de medicamentos en instituciones hospitalarias, incluso en terapias experimentales con uso de medicamentos off-label, para minimizar los riesgos y ampliar los posibles beneficios. Palabras clave: COVID-19. Hidroxicloroquina. Unidad de terapia intensiva.Introdução: Mesmo em emergências sanitárias, quando terapias experimentais são empregadas, é importante prezar pela segurança e eficácia no uso de medicamentos, e a análise de prescrições médicas é uma das maneiras de monitorar aspectos de segurança. Objetivo: Quantificar e classificar as Interações Medicamentosas Potenciais (IMP) com Hidroxicloroquina (HCQ) de acordo com o risco em prescrições de pacientes com COVID-19. Metodologia: Este estudo transversal baseou-se na análise de 162 prescrições de 38 pacientes admitidos em uma Unidade de Terapia Intensiva (UTI) de um Hospital de ensino entre abril e junho de 2020. O Micromedex® e o UpToDate® foram as bases de dados de apoio à conduta clínica utilizadas para estabelecer as IMP. Resultados: A média de dias de internamento foi de 16,1 ± 14,0 e a média de dias em uso de HCQ foi de 4,26 ± 1,74. 87,14% das prescrições apresentaram IMP e a mais comum foi entre HCQ e azitromicina. 76,4% das prescrições analisadas apresentaram IMP com HCQ. 73,5% das prescrições tiveram pelo menos uma IMP entre medicamentos que prolongam o intervalo QT. Conclusões: Tendo em vista os riscos da exposição de pacientes críticos às interações medicamentosas, este estudo demonstra a necessidade de fortalecer nas instituições hospitalares a cultura de monitoramento de parâmetros de segurança e eficácia no uso de medicamentos, inclusive em terapias experimentais com a utilização de medicamentos off-label para minimizar riscos e ampliar possíveis benefícios Palavras-Chave: COVID-19. Hidroxicloroquina. Unidade de Terapia Intensiva.Portal de Periódicos Eletrônicos da UFRN2023-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigo avaliado pelos Paresapplication/pdfhttps://periodicos.ufrn.br/rcp/article/view/3062810.21680/2446-7286.2023v9n2ID30628Revista Ciência Plural; v. 9 n. 2 (2023): Revista Ciência Plural; 1-192446-728610.21680/2446-7286.2023v9n2reponame:Revista Ciência Pluralinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNporhttps://periodicos.ufrn.br/rcp/article/view/30628/17342Copyright (c) 2023 Revista Ciência Pluralhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessOliveira Carneiro, GeovannaSilva de Medeiros, Jordan CarlosFacundes Barbosa do Nascimento, Erika MichelleMonte Moreira, Francisca Sueli2023-08-31T23:26:53Zoai:periodicos.ufrn.br:article/30628Revistahttps://periodicos.ufrn.br/rcpPUBhttps://periodicos.ufrn.br/rcp/oai||irisdoceu.ufrn@gmail.com2446-72862446-7286opendoar:2023-08-31T23:26:53Revista Ciência Plural - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.none.fl_str_mv |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit Introduction: Even in health emergencies, when experimental therapies are used, it is important to regard the medication safety and efficacy, and the analysis of medical prescriptions is one of the ways to monitor safety aspects. Objective: quantify and c ANÁLISE DAS PRESCRIÇÕES DE PACIENTES COM COVID-19 EM USO DE HIDROXICLOROQUINA EM UMA UNIDADE DE TERAPIA INTENSIVA |
title |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit |
spellingShingle |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit Oliveira Carneiro, Geovanna |
title_short |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit |
title_full |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit |
title_fullStr |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit |
title_full_unstemmed |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit |
title_sort |
Analysis of COVID-19 Patients Prescriptions Using Hydroxychloroquine in an Intensive Care Unit |
author |
Oliveira Carneiro, Geovanna |
author_facet |
Oliveira Carneiro, Geovanna Silva de Medeiros, Jordan Carlos Facundes Barbosa do Nascimento, Erika Michelle Monte Moreira, Francisca Sueli |
author_role |
author |
author2 |
Silva de Medeiros, Jordan Carlos Facundes Barbosa do Nascimento, Erika Michelle Monte Moreira, Francisca Sueli |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Oliveira Carneiro, Geovanna Silva de Medeiros, Jordan Carlos Facundes Barbosa do Nascimento, Erika Michelle Monte Moreira, Francisca Sueli |
description |
Introduction: Even in health emergencies, when experimental therapies are used, it is important to regard the medication safety and efficacy, and the analysis of medical prescriptions is one of the ways to monitor safety aspects. Objective: quantify and classify Potential Drug Interactions (PDIs) with Hydroxychloroquine (HCQ) according to risk in prescriptions for patients with COVID-19 in use of HCQ admitted to an Intensive Care Unit (ICU) of a Teaching Hospital. Methodology: This cross-sectional study was based on the analysis of 162 prescriptions from 38 patients with COVID-19 using HCQ in an ICU. Micromedex® and UpToDate® were the databases to support clinical management used to establish PDI. Results: The mean number of days of hospitalization was 16.1 ± 14.0 and the mean number of days using HCQ was 4.26 ± 1.74. 87.14% of prescriptions presented PDI and the most common was between HCQ and azithromycin. 77.77% of prescriptions had at least one PDI between drugs that prolong the QT interval. Conclusions: Considering the risks of exposing critical patients to drug interactions, this study demonstrates the need to strengthen the culture of monitoring drug safety and efficacy parameters in health institutions, even in experimental therapies with utilization off-label drugs indication, to minimize risks and expand possible benefits. Keywords: COVID-19. Hydroxychloroquine. Intensive Care Unit. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigo avaliado pelos Pares |
format |
article |
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publishedVersion |
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https://periodicos.ufrn.br/rcp/article/view/30628 10.21680/2446-7286.2023v9n2ID30628 |
url |
https://periodicos.ufrn.br/rcp/article/view/30628 |
identifier_str_mv |
10.21680/2446-7286.2023v9n2ID30628 |
dc.language.iso.fl_str_mv |
por |
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por |
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https://periodicos.ufrn.br/rcp/article/view/30628/17342 |
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Copyright (c) 2023 Revista Ciência Plural https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
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Copyright (c) 2023 Revista Ciência Plural https://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Portal de Periódicos Eletrônicos da UFRN |
publisher.none.fl_str_mv |
Portal de Periódicos Eletrônicos da UFRN |
dc.source.none.fl_str_mv |
Revista Ciência Plural; v. 9 n. 2 (2023): Revista Ciência Plural; 1-19 2446-7286 10.21680/2446-7286.2023v9n2 reponame:Revista Ciência Plural instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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Revista Ciência Plural |
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Revista Ciência Plural |
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Revista Ciência Plural - Universidade Federal do Rio Grande do Norte (UFRN) |
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||irisdoceu.ufrn@gmail.com |
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