Sleep disrupts complex spiking dynamics in the neocortex and hippocampus
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54971 |
Resumo: | Neuronal interactions give rise to complex dynamics in cortical networks, often described in terms of the diversity of activity patterns observed in a neural signal. Interestingly, the complexity of spontaneous electroencephalographic signals decreases during slow-wave sleep (SWS); however, the underlying neural mechanisms remain elusive. Here, we analyse in-vivo recordings from neocortical and hippocampal neuronal populations in rats and show that the complexity decrease is due to the emergence of synchronous neuronal DOWN states. Namely, we find that DOWN states during SWS force the population activity to be more recurrent, deterministic, and less random than during REM sleep or wakefulness, which, in turn, leads to less complex field recordings. Importantly, when we exclude DOWN states from the analysis, the recordings during wakefulness and sleep become indistinguishable: the spiking activity in all the states collapses to a common scaling. We complement these results by implementing a critical branching model of the cortex, which shows that inducing DOWN states to only a percentage of neurons is enough to generate a decrease in complexity that replicates SWS |
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González, JoaquínCavelli, MatiasTort, Adriano Bretanha LopesTorterolo, PabloRubido, Nicolás2023-10-11T17:30:20Z2023-10-11T17:30:20Z2023-08GONZÁLEZ, Joaquín; CAVELLI, Matias; TORT, Adriano B. L.; TORTEROLO, Pablo; RUBIDO, Nicolás. Sleep disrupts complex spiking dynamics in the neocortex and hippocampus. Plos One, [S. l.], v. 18, n. 8, p. e0290146, ago. 2023. Doi: http://dx.doi.org/10.1371/journal.pone.0290146. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0290146. Acesso em: 11 out. 2023https://repositorio.ufrn.br/handle/123456789/5497110.1371/journal.pone.0290146Public Library of Science (PLoS)Attribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessSleep - NeocortexSleep - HippocampusSpontaneous electroencephalographic signals - Slow-wave sleep (SWS)Neuronal DOWN statesNeuronal modellingIn-vivo neuronal populationsSleep disrupts complex spiking dynamics in the neocortex and hippocampusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNeuronal interactions give rise to complex dynamics in cortical networks, often described in terms of the diversity of activity patterns observed in a neural signal. Interestingly, the complexity of spontaneous electroencephalographic signals decreases during slow-wave sleep (SWS); however, the underlying neural mechanisms remain elusive. Here, we analyse in-vivo recordings from neocortical and hippocampal neuronal populations in rats and show that the complexity decrease is due to the emergence of synchronous neuronal DOWN states. Namely, we find that DOWN states during SWS force the population activity to be more recurrent, deterministic, and less random than during REM sleep or wakefulness, which, in turn, leads to less complex field recordings. Importantly, when we exclude DOWN states from the analysis, the recordings during wakefulness and sleep become indistinguishable: the spiking activity in all the states collapses to a common scaling. We complement these results by implementing a critical branching model of the cortex, which shows that inducing DOWN states to only a percentage of neurons is enough to generate a decrease in complexity that replicates SWSengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALSleepDisruptsComplex_Tort_2023.pdfSleepDisruptsComplex_Tort_2023.pdfSleepDisruptsComplex_Tort_2023application/pdf3185741https://repositorio.ufrn.br/bitstream/123456789/54971/1/SleepDisruptsComplex_Tort_2023.pdfbd104fa19a4afc334b4b4a8bac3ee452MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/54971/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54971/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/549712023-10-11 14:30:20.809oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-10-11T17:30:20Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
title |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
spellingShingle |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus González, Joaquín Sleep - Neocortex Sleep - Hippocampus Spontaneous electroencephalographic signals - Slow-wave sleep (SWS) Neuronal DOWN states Neuronal modelling In-vivo neuronal populations |
title_short |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
title_full |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
title_fullStr |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
title_full_unstemmed |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
title_sort |
Sleep disrupts complex spiking dynamics in the neocortex and hippocampus |
author |
González, Joaquín |
author_facet |
González, Joaquín Cavelli, Matias Tort, Adriano Bretanha Lopes Torterolo, Pablo Rubido, Nicolás |
author_role |
author |
author2 |
Cavelli, Matias Tort, Adriano Bretanha Lopes Torterolo, Pablo Rubido, Nicolás |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
González, Joaquín Cavelli, Matias Tort, Adriano Bretanha Lopes Torterolo, Pablo Rubido, Nicolás |
dc.subject.por.fl_str_mv |
Sleep - Neocortex Sleep - Hippocampus Spontaneous electroencephalographic signals - Slow-wave sleep (SWS) Neuronal DOWN states Neuronal modelling In-vivo neuronal populations |
topic |
Sleep - Neocortex Sleep - Hippocampus Spontaneous electroencephalographic signals - Slow-wave sleep (SWS) Neuronal DOWN states Neuronal modelling In-vivo neuronal populations |
description |
Neuronal interactions give rise to complex dynamics in cortical networks, often described in terms of the diversity of activity patterns observed in a neural signal. Interestingly, the complexity of spontaneous electroencephalographic signals decreases during slow-wave sleep (SWS); however, the underlying neural mechanisms remain elusive. Here, we analyse in-vivo recordings from neocortical and hippocampal neuronal populations in rats and show that the complexity decrease is due to the emergence of synchronous neuronal DOWN states. Namely, we find that DOWN states during SWS force the population activity to be more recurrent, deterministic, and less random than during REM sleep or wakefulness, which, in turn, leads to less complex field recordings. Importantly, when we exclude DOWN states from the analysis, the recordings during wakefulness and sleep become indistinguishable: the spiking activity in all the states collapses to a common scaling. We complement these results by implementing a critical branching model of the cortex, which shows that inducing DOWN states to only a percentage of neurons is enough to generate a decrease in complexity that replicates SWS |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-10-11T17:30:20Z |
dc.date.available.fl_str_mv |
2023-10-11T17:30:20Z |
dc.date.issued.fl_str_mv |
2023-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GONZÁLEZ, Joaquín; CAVELLI, Matias; TORT, Adriano B. L.; TORTEROLO, Pablo; RUBIDO, Nicolás. Sleep disrupts complex spiking dynamics in the neocortex and hippocampus. Plos One, [S. l.], v. 18, n. 8, p. e0290146, ago. 2023. Doi: http://dx.doi.org/10.1371/journal.pone.0290146. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0290146. Acesso em: 11 out. 2023 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54971 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0290146 |
identifier_str_mv |
GONZÁLEZ, Joaquín; CAVELLI, Matias; TORT, Adriano B. L.; TORTEROLO, Pablo; RUBIDO, Nicolás. Sleep disrupts complex spiking dynamics in the neocortex and hippocampus. Plos One, [S. l.], v. 18, n. 8, p. e0290146, ago. 2023. Doi: http://dx.doi.org/10.1371/journal.pone.0290146. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0290146. Acesso em: 11 out. 2023 10.1371/journal.pone.0290146 |
url |
https://repositorio.ufrn.br/handle/123456789/54971 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science (PLoS) |
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Public Library of Science (PLoS) |
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