Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFRN |
| Texto Completo: | https://repositorio.ufrn.br/jspui/handle/1/6200 |
Resumo: | TORRES, F ; FILHO, M.S. ; ANTUNES, C. ; KALININE, E. ; ANTONIOLLI, E. ; PORTELA, Luis Valmor ; SOUZA, Diogo Onofre ; TORT, A. B. L. . Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model. Experimental Neurology , v. 221, p. 296-306, 2010 |
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Torres, Felipe V.Silva Filho, Manoel daAntunes, CatieleKalinine, EduardoAntoniolli, EduardoPortela, Luis V.C.Souza, Diogo O.Tort, Adriano Bretanha Lopes2013-02-25T12:39:06Z2013-02-25T12:39:06Z2010TORRES, F ; FILHO, M.S. ; ANTUNES, C. ; KALININE, E. ; ANTONIOLLI, E. ; PORTELA, Luis Valmor ; SOUZA, Diogo Onofre ; TORT, A. B. L. ., (2010)https://repositorio.ufrn.br/jspui/handle/1/6200TORRES, F ; FILHO, M.S. ; ANTUNES, C. ; KALININE, E. ; ANTONIOLLI, E. ; PORTELA, Luis Valmor ; SOUZA, Diogo Onofre ; TORT, A. B. L. . Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model. Experimental Neurology , v. 221, p. 296-306, 2010Quinolinic acid (QA) is an N-methyl-D-aspartate receptor agonist that also promotes glutamate release and inhibits glutamate uptake by astrocytes. QA is used in experimental models of seizures studying the effects of overstimulation of the glutamatergic system. The guanine-based purines (GBPs), including the nucleoside guanosine, have been shown to modulate the glutamatergic system when administered extracellularly. GBPs were shown to inhibit the binding of glutamate and analogs, to be neuroprotective under excitotoxic conditions, as well as anticonvulsant against seizures induced by glutamatergic agents, including QA-induced seizure. In this work, we studied the electrophysiological effects of guanosine against QA-induced epileptiform activity in rats at the macroscopic cortical level, as inferred by electroencephalogram (EEG) signals recorded at the epidural surface. We found that QA disrupts a prominent basal theta (4–10 Hz) activity during peri-ictal periods and also promotes a relative increase in gamma (20–50 Hz) oscillations. Guanosine, when successfully preventing seizures, counteracted both these spectral changes. MK-801, an NMDA-antagonist used as positive control, was also able counteract the decrease in theta power; however, we observed an increase in the power of gamma oscillations in rats concurrently treated with MK-801 and QA. Given the distinct spectral signatures, these results suggest that guanosine and MK-801 prevent QAinduced seizures by different network mechanisms.engEEGSeizureEpilepsyThetaGammaNeuroprotectionAEDElectrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALAdrianoBLTort_ICE_Electrophysiological2010.pdfAdrianoBLTort_ICE_Electrophysiological2010.pdfapplication/pdf2155271https://repositorio.ufrn.br/bitstream/1/6200/1/AdrianoBLTort_ICE_Electrophysiological2010.pdfd8710af5c9f6d7e89fb19263d2635d66MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/1/6200/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAdrianoBLTort_ICE_Electrophysiological2010.pdf.txtAdrianoBLTort_ICE_Electrophysiological2010.pdf.txtExtracted texttext/plain48657https://repositorio.ufrn.br/bitstream/1/6200/7/AdrianoBLTort_ICE_Electrophysiological2010.pdf.txt8b0735ccaab33129f58e6254f0cb7b1eMD57THUMBNAILAdrianoBLTort_ICE_Electrophysiological2010.pdf.jpgAdrianoBLTort_ICE_Electrophysiological2010.pdf.jpgIM Thumbnailimage/jpeg8739https://repositorio.ufrn.br/bitstream/1/6200/8/AdrianoBLTort_ICE_Electrophysiological2010.pdf.jpg9e44c6c475a83287cd8d191ae263796bMD581/62002021-07-08 11:26:19.555oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T14:26:19Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
| dc.title.pt_BR.fl_str_mv |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| title |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| spellingShingle |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model Torres, Felipe V. EEG Seizure Epilepsy Theta Gamma Neuroprotection AED |
| title_short |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| title_full |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| title_fullStr |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| title_full_unstemmed |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| title_sort |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model |
| author |
Torres, Felipe V. |
| author_facet |
Torres, Felipe V. Silva Filho, Manoel da Antunes, Catiele Kalinine, Eduardo Antoniolli, Eduardo Portela, Luis V.C. Souza, Diogo O. Tort, Adriano Bretanha Lopes |
| author_role |
author |
| author2 |
Silva Filho, Manoel da Antunes, Catiele Kalinine, Eduardo Antoniolli, Eduardo Portela, Luis V.C. Souza, Diogo O. Tort, Adriano Bretanha Lopes |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Torres, Felipe V. Silva Filho, Manoel da Antunes, Catiele Kalinine, Eduardo Antoniolli, Eduardo Portela, Luis V.C. Souza, Diogo O. Tort, Adriano Bretanha Lopes |
| dc.subject.por.fl_str_mv |
EEG Seizure Epilepsy Theta Gamma Neuroprotection AED |
| topic |
EEG Seizure Epilepsy Theta Gamma Neuroprotection AED |
| description |
TORRES, F ; FILHO, M.S. ; ANTUNES, C. ; KALININE, E. ; ANTONIOLLI, E. ; PORTELA, Luis Valmor ; SOUZA, Diogo Onofre ; TORT, A. B. L. . Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model. Experimental Neurology , v. 221, p. 296-306, 2010 |
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2010 |
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2010 |
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2013-02-25T12:39:06Z |
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2013-02-25T12:39:06Z |
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TORRES, F ; FILHO, M.S. ; ANTUNES, C. ; KALININE, E. ; ANTONIOLLI, E. ; PORTELA, Luis Valmor ; SOUZA, Diogo Onofre ; TORT, A. B. L. ., (2010) |
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https://repositorio.ufrn.br/jspui/handle/1/6200 |
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TORRES, F ; FILHO, M.S. ; ANTUNES, C. ; KALININE, E. ; ANTONIOLLI, E. ; PORTELA, Luis Valmor ; SOUZA, Diogo Onofre ; TORT, A. B. L. ., (2010) |
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