Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/57713 http://dx.doi.org/10.1002/ppul.22621 |
Resumo: | Objective: To assess whether vitamin A deficiency alters the recovery of total respiratory resistance (TRR) following acute upper respiratory tract infection (URI). Methods: This is a case control study of children, age 4–6 years and grouped as: URI, (n = 74), URI and wheezing, (URI-wheezing, n = 52), and healthy controls (n = 51). Vitamin A and total respiratory resistance (TRR) were assessed using the modified relative dose response (MRDR) and forced oscillometry, respectively. Results: Children with URI and URI-wheezing had lower retinol, 32.4 ± 13.12 and 18.3 ± 6.83 µg/dl respectively, compared to controls, 56.9 ± 29.82 µg/dl (ANOVA, P < 0.001). The MRDR was elevated in children in the URI or URI-wheezing groups 0.066 ± 0.045 and 0.021 ± 0.021, respectively, compared to controls 0.007 ± 0.006 (ANOVA, P < 0.0001). The TRR in the URI and URI-wheezing groups differed from controls. During convalescence, the TRR failed to decline in the URI-group only when the MRDR was >0.06. In the URI-wheezing group, TRR declined independently of retinol and MRDR. Conclusion: Vitamin A contributes to preservation of airway function during and in recovery after upper respiratory infection in children |
id |
UFRN_09e17b4d1f828115f525ea140d03f7bc |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/57713 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Maciel, Bruna Leal LimaAmaral, Cléia Teixeira doPontes, Núbia NatalyBezerra, Hugo Sailly MouraTrieste, Ana Nataly Adriane BezerraJerônimo, Selma Maria BezerraMcGowan, Stephen E.Dantas, Vera Maria2024-02-28T20:12:39Z2024-02-28T20:12:39Z2012-07AMARAL, Cléia Teixeira do; PONTES, Núbia Nataly; MACIEL, Bruna Leal Lima; BEZERRA, Hugo Sailly Moura; TRIESTE, Ana Nataly Adriane Bezerra; JERÔNIMO, Selma Maria Bezerra; MCGOWAN, Stephen E.; DANTAS, Vera Maria. Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection. Pediatric Pulmonology, [S.l.], v. 48, n. 5, p. 481-489, 25 jul. 2012. DOI: 10.1002/ppul.22621. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ppul.22621. Acesso em: 6 fev. 2024.https://repositorio.ufrn.br/handle/123456789/57713http://dx.doi.org/10.1002/ppul.22621Pediatric PulmonologyVitamin A deficiencyAirway resistanceUpper respiratory infectionChildrenVitamin A deficiency alters airway resistance in children with acute upper respiratory infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjective: To assess whether vitamin A deficiency alters the recovery of total respiratory resistance (TRR) following acute upper respiratory tract infection (URI). Methods: This is a case control study of children, age 4–6 years and grouped as: URI, (n = 74), URI and wheezing, (URI-wheezing, n = 52), and healthy controls (n = 51). Vitamin A and total respiratory resistance (TRR) were assessed using the modified relative dose response (MRDR) and forced oscillometry, respectively. Results: Children with URI and URI-wheezing had lower retinol, 32.4 ± 13.12 and 18.3 ± 6.83 µg/dl respectively, compared to controls, 56.9 ± 29.82 µg/dl (ANOVA, P < 0.001). The MRDR was elevated in children in the URI or URI-wheezing groups 0.066 ± 0.045 and 0.021 ± 0.021, respectively, compared to controls 0.007 ± 0.006 (ANOVA, P < 0.0001). The TRR in the URI and URI-wheezing groups differed from controls. During convalescence, the TRR failed to decline in the URI-group only when the MRDR was >0.06. In the URI-wheezing group, TRR declined independently of retinol and MRDR. Conclusion: Vitamin A contributes to preservation of airway function during and in recovery after upper respiratory infection in childrenengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/57713/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/577132024-02-28 17:20:43.927oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-02-28T20:20:43Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
title |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
spellingShingle |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection Maciel, Bruna Leal Lima Vitamin A deficiency Airway resistance Upper respiratory infection Children |
title_short |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
title_full |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
title_fullStr |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
title_full_unstemmed |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
title_sort |
Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection |
author |
Maciel, Bruna Leal Lima |
author_facet |
Maciel, Bruna Leal Lima Amaral, Cléia Teixeira do Pontes, Núbia Nataly Bezerra, Hugo Sailly Moura Trieste, Ana Nataly Adriane Bezerra Jerônimo, Selma Maria Bezerra McGowan, Stephen E. Dantas, Vera Maria |
author_role |
author |
author2 |
Amaral, Cléia Teixeira do Pontes, Núbia Nataly Bezerra, Hugo Sailly Moura Trieste, Ana Nataly Adriane Bezerra Jerônimo, Selma Maria Bezerra McGowan, Stephen E. Dantas, Vera Maria |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Maciel, Bruna Leal Lima Amaral, Cléia Teixeira do Pontes, Núbia Nataly Bezerra, Hugo Sailly Moura Trieste, Ana Nataly Adriane Bezerra Jerônimo, Selma Maria Bezerra McGowan, Stephen E. Dantas, Vera Maria |
dc.subject.por.fl_str_mv |
Vitamin A deficiency Airway resistance Upper respiratory infection Children |
topic |
Vitamin A deficiency Airway resistance Upper respiratory infection Children |
description |
Objective: To assess whether vitamin A deficiency alters the recovery of total respiratory resistance (TRR) following acute upper respiratory tract infection (URI). Methods: This is a case control study of children, age 4–6 years and grouped as: URI, (n = 74), URI and wheezing, (URI-wheezing, n = 52), and healthy controls (n = 51). Vitamin A and total respiratory resistance (TRR) were assessed using the modified relative dose response (MRDR) and forced oscillometry, respectively. Results: Children with URI and URI-wheezing had lower retinol, 32.4 ± 13.12 and 18.3 ± 6.83 µg/dl respectively, compared to controls, 56.9 ± 29.82 µg/dl (ANOVA, P < 0.001). The MRDR was elevated in children in the URI or URI-wheezing groups 0.066 ± 0.045 and 0.021 ± 0.021, respectively, compared to controls 0.007 ± 0.006 (ANOVA, P < 0.0001). The TRR in the URI and URI-wheezing groups differed from controls. During convalescence, the TRR failed to decline in the URI-group only when the MRDR was >0.06. In the URI-wheezing group, TRR declined independently of retinol and MRDR. Conclusion: Vitamin A contributes to preservation of airway function during and in recovery after upper respiratory infection in children |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-07 |
dc.date.accessioned.fl_str_mv |
2024-02-28T20:12:39Z |
dc.date.available.fl_str_mv |
2024-02-28T20:12:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
AMARAL, Cléia Teixeira do; PONTES, Núbia Nataly; MACIEL, Bruna Leal Lima; BEZERRA, Hugo Sailly Moura; TRIESTE, Ana Nataly Adriane Bezerra; JERÔNIMO, Selma Maria Bezerra; MCGOWAN, Stephen E.; DANTAS, Vera Maria. Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection. Pediatric Pulmonology, [S.l.], v. 48, n. 5, p. 481-489, 25 jul. 2012. DOI: 10.1002/ppul.22621. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ppul.22621. Acesso em: 6 fev. 2024. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/57713 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1002/ppul.22621 |
identifier_str_mv |
AMARAL, Cléia Teixeira do; PONTES, Núbia Nataly; MACIEL, Bruna Leal Lima; BEZERRA, Hugo Sailly Moura; TRIESTE, Ana Nataly Adriane Bezerra; JERÔNIMO, Selma Maria Bezerra; MCGOWAN, Stephen E.; DANTAS, Vera Maria. Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection. Pediatric Pulmonology, [S.l.], v. 48, n. 5, p. 481-489, 25 jul. 2012. DOI: 10.1002/ppul.22621. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ppul.22621. Acesso em: 6 fev. 2024. |
url |
https://repositorio.ufrn.br/handle/123456789/57713 http://dx.doi.org/10.1002/ppul.22621 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Pediatric Pulmonology |
publisher.none.fl_str_mv |
Pediatric Pulmonology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/57713/2/license.txt |
bitstream.checksum.fl_str_mv |
e9597aa2854d128fd968be5edc8a28d9 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117515511332864 |