Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection

• Autor(a) principal: Maciel, Bruna Leal Lima
• Data de Publicação: 2012
• Outros Autores: Amaral, Cléia Teixeira do, Pontes, Núbia Nataly, Bezerra, Hugo Sailly Moura, Trieste, Ana Nataly Adriane Bezerra, Jerônimo, Selma Maria Bezerra, McGowan, Stephen E., Dantas, Vera Maria
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/57713; http://dx.doi.org/10.1002/ppul.22621
• topic: Vitamin A deficiency; Airway resistance; Upper respiratory infection; Children

Objective: To assess whether vitamin A deficiency alters the recovery of total respiratory resistance (TRR) following acute upper respiratory tract infection (URI). Methods: This is a case control study of children, age 4–6 years and grouped as: URI, (n = 74), URI and wheezing, (URI-wheezing, n = 52), and healthy controls (n = 51). Vitamin A and total respiratory resistance (TRR) were assessed using the modified relative dose response (MRDR) and forced oscillometry, respectively. Results: Children with URI and URI-wheezing had lower retinol, 32.4 ± 13.12 and 18.3 ± 6.83 µg/dl respectively, compared to controls, 56.9 ± 29.82 µg/dl (ANOVA, P < 0.001). The MRDR was elevated in children in the URI or URI-wheezing groups 0.066 ± 0.045 and 0.021 ± 0.021, respectively, compared to controls 0.007 ± 0.006 (ANOVA, P < 0.0001). The TRR in the URI and URI-wheezing groups differed from controls. During convalescence, the TRR failed to decline in the URI-group only when the MRDR was >0.06. In the URI-wheezing group, TRR declined independently of retinol and MRDR. Conclusion: Vitamin A contributes to preservation of airway function during and in recovery after upper respiratory infection in children