Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use

Detalhes bibliográficos
Autor(a) principal: Santos, Milena Lima Valério dos
Data de Publicação: 2019
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/35774
Resumo: 2022-01-01
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spelling Santos, Milena Lima Valério dosLucas Azevedo do NascimentoMedeiros, Arthur Sérgio Avelino deSilva, Edilamar Pereira daSilva Júnior, Arnóbio Antônio da2019-11-22T19:46:11Z2021-09-20T17:51:12Z2019-11-22T19:46:11Z2019-11-0620150118353SANTOS, Milena Lima Valério dos. Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use. 2019. 26f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/handle/123456789/35774Universidade Federal do Rio Grande do NorteUFRNBrasilFarmáciaAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessNanoemulsionNanogelIbuprofenPoloxamer 407Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical useinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesis2022-01-01Ibuprofen (IBF) is a non-steroidal anti-inflammatory drug (NSAID) that has analgesic, antipyretic and anti-inflammatory action, but is a poorly soluble drug. Aiming at improving the bioavailability of this drug, this study aimed to develop ibuprofen-containing nanoemulsions (NE) and gelatinized nanoemulsions (NEG) for possible topical use. Nanoemulsions were prepared using low energy technique at different surfactant concentrations. For the gelation of nanoemulsions a copolymer with thermoreversible properties was used in different proportions, being Poloxamer 407 (Pluronic F127®). The characteristics of both systems were evaluated with respect to average droplet size, polydispersion index and zeta potential. All samples presented nanometer droplet size and negative zeta potential; The polydispersion index values were variable. The selected nanoemulsion was translucent and had stable droplet size and polydispersion index over a period of 60 days. This system then received ibuprofen and the same characteristics were evaluated and the formulation was stable for 15 days. Afterwards, the empty and drug nanoemulsions were gelled with Pluronic F127® (F127) and maintained their stability for more than 40 days, maintaining their nanometric characteristics during the study. In addition, the in vitro release study showed that within 6 hours, it is possible that about 50% of the drug will be released, and after that release will remain constant. Thus, we can see that the development of NE can improve the bioavailability of IBF and that nanogels are a vehicle option for improving topical administration of this drug.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALDevelopmentOfThermoresponsive_Santos_2019.pdfapplication/pdf625731https://repositorio.ufrn.br/bitstream/123456789/35774/1/DevelopmentOfThermoresponsive_Santos_2019.pdf26ad703ee6b7179907efd74c1039b6a1MD51CC-LICENSElicense_rdfapplication/octet-stream811https://repositorio.ufrn.br/bitstream/123456789/35774/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txttext/plain762https://repositorio.ufrn.br/bitstream/123456789/35774/3/license.txte428689918449bd69f843393981e4109MD53TEXTDevelopmentOfThermoresponsive_Santos_2019.pdf.txtExtracted texttext/plain42890https://repositorio.ufrn.br/bitstream/123456789/35774/4/DevelopmentOfThermoresponsive_Santos_2019.pdf.txt250dbbe03d9e0f3caad27e56fd1dda33MD54123456789/357742024-03-19 01:01:15.934oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-19T04:01:15Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
spellingShingle Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
Santos, Milena Lima Valério dos
Nanoemulsion
Nanogel
Ibuprofen
Poloxamer 407
title_short Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_full Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_fullStr Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_full_unstemmed Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
title_sort Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use
author Santos, Milena Lima Valério dos
author_facet Santos, Milena Lima Valério dos
author_role author
dc.contributor.referees1.none.fl_str_mv Medeiros, Arthur Sérgio Avelino de
dc.contributor.referees2.none.fl_str_mv Silva, Edilamar Pereira da
dc.contributor.author.fl_str_mv Santos, Milena Lima Valério dos
dc.contributor.advisor-co1.fl_str_mv Lucas Azevedo do Nascimento
dc.contributor.advisor1.fl_str_mv Silva Júnior, Arnóbio Antônio da
contributor_str_mv Lucas Azevedo do Nascimento
Silva Júnior, Arnóbio Antônio da
dc.subject.por.fl_str_mv Nanoemulsion
Nanogel
Ibuprofen
Poloxamer 407
topic Nanoemulsion
Nanogel
Ibuprofen
Poloxamer 407
description 2022-01-01
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-11-22T19:46:11Z
2021-09-20T17:51:12Z
dc.date.available.fl_str_mv 2019-11-22T19:46:11Z
dc.date.issued.fl_str_mv 2019-11-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.pt_BR.fl_str_mv 20150118353
dc.identifier.citation.fl_str_mv SANTOS, Milena Lima Valério dos. Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use. 2019. 26f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/35774
identifier_str_mv 20150118353
SANTOS, Milena Lima Valério dos. Development of thermoresponsive ibuprofen nanoemulsion based-gel for potential topical use. 2019. 26f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.
url https://repositorio.ufrn.br/handle/123456789/35774
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.initials.fl_str_mv UFRN
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Farmácia
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
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