Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/21787 |
Resumo: | Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue. |
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Barros, Simone Souza Lobão VerasHenriques, Águida Cristina GomesPereira, Karuza Maria AlvesMedeiros, Ana Miryam Costa deGalvão, Hebel CavalcantiFreitas, Roseana de Almeida2017-01-30T11:51:48Z2017-01-30T11:51:48Z2011BARROS, Simone Souza Lobão Veras et al. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Archives of Oral Biology , v. 56, n.8, p. 752-760, 2011.https://repositorio.ufrn.br/jspui/handle/123456789/21787engMatrix metalloproteinasesImmunohistochemistryCarcinomaImmunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lipinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/21787/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52TEXTImmunohistochemical expression of matrix metalloproteinases_2011.pdf.txtImmunohistochemical expression of matrix metalloproteinases_2011.pdf.txtExtracted texttext/plain37592https://repositorio.ufrn.br/bitstream/123456789/21787/5/Immunohistochemical%20expression%20of%20matrix%20metalloproteinases_2011.pdf.txt9e7008727b2cd268d3375b7bb794b23dMD55THUMBNAILImmunohistochemical expression of matrix metalloproteinases_2011.pdf.jpgImmunohistochemical expression of matrix metalloproteinases_2011.pdf.jpgIM Thumbnailimage/jpeg8738https://repositorio.ufrn.br/bitstream/123456789/21787/6/Immunohistochemical%20expression%20of%20matrix%20metalloproteinases_2011.pdf.jpg204c44248e5af7c3b5302f2952a58ccdMD56123456789/217872022-12-15 18:46:04.15oai:https://repositorio.ufrn.br:123456789/21787TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkZSBhdXRvcik6CgphKSBDb25jZWRlIMOgIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRvIFJpbyBHcmFuZGUgZG8gTm9ydGUgbyBkaXJlaXRvIG7Do28tZXhjbHVzaXZvIGRlCnJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhYmFpeG8pLCBjb211bmljYXIgZS9vdQpkaXN0cmlidWlyIG8gZG9jdW1lbnRvIGVudHJlZ3VlIChpbmNsdWluZG8gbyByZXN1bW8vYWJzdHJhY3QpIGVtCmZvcm1hdG8gZGlnaXRhbCBvdSBpbXByZXNzbyBlIGVtIHF1YWxxdWVyIG1laW8uCgpiKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDDqSBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlCmRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgb3MgZGlyZWl0b3MgY29udGlkb3MgbmVzdGEgbGljZW7Dp2EuIERlY2xhcmEKdGFtYsOpbSBxdWUgYSBlbnRyZWdhIGRvIGRvY3VtZW50byBuw6NvIGluZnJpbmdlLCB0YW50byBxdWFudG8gbGhlIMOpCnBvc3PDrXZlbCBzYWJlciwgb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKYykgU2UgbyBkb2N1bWVudG8gZW50cmVndWUgY29udMOpbSBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zCmRpcmVpdG9zIGRlIGF1dG9yLCBkZWNsYXJhIHF1ZSBvYnRldmUgYXV0b3JpemHDp8OjbyBkbyBkZXRlbnRvciBkb3MKZGlyZWl0b3MgZGUgYXV0b3IgcGFyYSBjb25jZWRlciDDoCBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW7Dp2EsIGUgcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZQp0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdQpjb250ZcO6ZG8gZG8gZG9jdW1lbnRvIGVudHJlZ3VlLgoKU2UgbyBkb2N1bWVudG8gZW50cmVndWUgw6kgYmFzZWFkbyBlbSB0cmFiYWxobyBmaW5hbmNpYWRvIG91IGFwb2lhZG8KcG9yIG91dHJhIGluc3RpdHVpw6fDo28gcXVlIG7Do28gYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJhIHF1ZSBjdW1wcml1IHF1YWlzcXVlciBvYnJpZ2HDp8O1ZXMgZXhpZ2lkYXMgcGVsbyByZXNwZWN0aXZvIGNvbnRyYXRvIG91IGFjb3Jkby4KCkEgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSAgaWRlbnRpZmljYXLDoSBjbGFyYW1lbnRlIG8ocykgc2V1IChzKSBub21lKHMpIGNvbW8gbyAocykgYXV0b3IgKGVzKSBvdSBkZXRlbnRvciAoZXMpIGRvcyBkaXJlaXRvcyBkbyBkb2N1bWVudG8KZW50cmVndWUsIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbywgcGFyYSBhbMOpbSBkYXMgcGVybWl0aWRhcyBwb3IKZXN0YSBsaWNlbsOnYS4KRepositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-12-15T21:46:04Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
title |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
spellingShingle |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip Barros, Simone Souza Lobão Veras Matrix metalloproteinases Immunohistochemistry Carcinoma |
title_short |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
title_full |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
title_fullStr |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
title_full_unstemmed |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
title_sort |
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip |
author |
Barros, Simone Souza Lobão Veras |
author_facet |
Barros, Simone Souza Lobão Veras Henriques, Águida Cristina Gomes Pereira, Karuza Maria Alves Medeiros, Ana Miryam Costa de Galvão, Hebel Cavalcanti Freitas, Roseana de Almeida |
author_role |
author |
author2 |
Henriques, Águida Cristina Gomes Pereira, Karuza Maria Alves Medeiros, Ana Miryam Costa de Galvão, Hebel Cavalcanti Freitas, Roseana de Almeida |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Barros, Simone Souza Lobão Veras Henriques, Águida Cristina Gomes Pereira, Karuza Maria Alves Medeiros, Ana Miryam Costa de Galvão, Hebel Cavalcanti Freitas, Roseana de Almeida |
dc.subject.por.fl_str_mv |
Matrix metalloproteinases Immunohistochemistry Carcinoma |
topic |
Matrix metalloproteinases Immunohistochemistry Carcinoma |
description |
Objective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2017-01-30T11:51:48Z |
dc.date.available.fl_str_mv |
2017-01-30T11:51:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARROS, Simone Souza Lobão Veras et al. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Archives of Oral Biology , v. 56, n.8, p. 752-760, 2011. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/21787 |
identifier_str_mv |
BARROS, Simone Souza Lobão Veras et al. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Archives of Oral Biology , v. 56, n.8, p. 752-760, 2011. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/21787 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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