Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/29719 |
Resumo: | Avoidance memory reactivation at recall triggers hippocampal theta-gamma phase amplitude coupling (hPAC) only when it elicits hippocampus-dependent reconsolidation. However, it is not known whether there is a causal relationship between these phenomena. We found that in adult male Wistar rats, silencing the medial septum during recall did not affect avoidance memory expression or maintenance but abolished hPAC and the amnesia caused by the intra-hippocampal administration of reconsolidation blockers, both of which were restored by concomitant theta burst stimulation of the fimbria-fornix pathway. Remarkably, artificial hPAC generated by fimbria-fornix stimulation during recall of a learned avoidance response naturally resistant to hippocampus-dependent reconsolidation made it susceptible to reactivation-dependent amnesia. Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation, and suggest that generation of artificial hPAC at recall overcomes the boundary conditions of this process. |
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Radiske, AndressaGonzalez, Maria CarolinaOcazionez, Sergio Andrés CondeRossato, Janine InezKöhler, Cristiano AndréCammarota, Martín Pablo2020-07-24T13:01:19Z2020-07-24T13:01:19Z2020-07-13RADISKE, Andressa; GONZALEZ, Maria Carolina; CONDE-OCAZIONEZ, Sergio; ROSSATO, Janine I.; KÖHLER, Cristiano A.; CAMMAROTA, Martín. Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption. The Journal of Neuroscience, [S.l.], jul. 2020. http://dx.doi.org/10.1523/jneurosci.0259-20.2020. Disponível em: https://www.jneurosci.org/content/early/2020/07/13/JNEUROSCI.0259-20.2020. Acesso em: 24 jul. 2020.https://repositorio.ufrn.br/jspui/handle/123456789/2971910.1523/JNEUROSCI.0259-20.2020Society for NeuroscienceAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessTheta rhythmGamma rhythmStress disorders, post-traumaticAmnesiaMemory consolidationCross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruptioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAvoidance memory reactivation at recall triggers hippocampal theta-gamma phase amplitude coupling (hPAC) only when it elicits hippocampus-dependent reconsolidation. However, it is not known whether there is a causal relationship between these phenomena. We found that in adult male Wistar rats, silencing the medial septum during recall did not affect avoidance memory expression or maintenance but abolished hPAC and the amnesia caused by the intra-hippocampal administration of reconsolidation blockers, both of which were restored by concomitant theta burst stimulation of the fimbria-fornix pathway. Remarkably, artificial hPAC generated by fimbria-fornix stimulation during recall of a learned avoidance response naturally resistant to hippocampus-dependent reconsolidation made it susceptible to reactivation-dependent amnesia. Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation, and suggest that generation of artificial hPAC at recall overcomes the boundary conditions of this process.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALCross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdfCross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdfCross-frequencyPhase-amplitudeCoupling_Cammarota_2020application/pdf6002964https://repositorio.ufrn.br/bitstream/123456789/29719/1/Cross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf4bd43d51bd2b7d2ea68486eabd4a59c0MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/29719/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/29719/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTCross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf.txtCross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf.txtExtracted texttext/plain71016https://repositorio.ufrn.br/bitstream/123456789/29719/4/Cross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf.txt29f7525a29c8b4cfa5c025eb91bc7202MD54THUMBNAILCross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf.jpgCross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf.jpgGenerated Thumbnailimage/jpeg1550https://repositorio.ufrn.br/bitstream/123456789/29719/5/Cross-frequencyPhase-amplitudeCoupling_Cammarota_2020.pdf.jpg9c3e6f8d24efcbbd5a5002f59876edb4MD55123456789/297192020-07-26 04:52:58.985oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2020-07-26T07:52:58Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
title |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
spellingShingle |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption Radiske, Andressa Theta rhythm Gamma rhythm Stress disorders, post-traumatic Amnesia Memory consolidation |
title_short |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
title_full |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
title_fullStr |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
title_full_unstemmed |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
title_sort |
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption |
author |
Radiske, Andressa |
author_facet |
Radiske, Andressa Gonzalez, Maria Carolina Ocazionez, Sergio Andrés Conde Rossato, Janine Inez Köhler, Cristiano André Cammarota, Martín Pablo |
author_role |
author |
author2 |
Gonzalez, Maria Carolina Ocazionez, Sergio Andrés Conde Rossato, Janine Inez Köhler, Cristiano André Cammarota, Martín Pablo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Radiske, Andressa Gonzalez, Maria Carolina Ocazionez, Sergio Andrés Conde Rossato, Janine Inez Köhler, Cristiano André Cammarota, Martín Pablo |
dc.subject.por.fl_str_mv |
Theta rhythm Gamma rhythm Stress disorders, post-traumatic Amnesia Memory consolidation |
topic |
Theta rhythm Gamma rhythm Stress disorders, post-traumatic Amnesia Memory consolidation |
description |
Avoidance memory reactivation at recall triggers hippocampal theta-gamma phase amplitude coupling (hPAC) only when it elicits hippocampus-dependent reconsolidation. However, it is not known whether there is a causal relationship between these phenomena. We found that in adult male Wistar rats, silencing the medial septum during recall did not affect avoidance memory expression or maintenance but abolished hPAC and the amnesia caused by the intra-hippocampal administration of reconsolidation blockers, both of which were restored by concomitant theta burst stimulation of the fimbria-fornix pathway. Remarkably, artificial hPAC generated by fimbria-fornix stimulation during recall of a learned avoidance response naturally resistant to hippocampus-dependent reconsolidation made it susceptible to reactivation-dependent amnesia. Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation, and suggest that generation of artificial hPAC at recall overcomes the boundary conditions of this process. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-07-24T13:01:19Z |
dc.date.available.fl_str_mv |
2020-07-24T13:01:19Z |
dc.date.issued.fl_str_mv |
2020-07-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RADISKE, Andressa; GONZALEZ, Maria Carolina; CONDE-OCAZIONEZ, Sergio; ROSSATO, Janine I.; KÖHLER, Cristiano A.; CAMMAROTA, Martín. Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption. The Journal of Neuroscience, [S.l.], jul. 2020. http://dx.doi.org/10.1523/jneurosci.0259-20.2020. Disponível em: https://www.jneurosci.org/content/early/2020/07/13/JNEUROSCI.0259-20.2020. Acesso em: 24 jul. 2020. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/29719 |
dc.identifier.doi.none.fl_str_mv |
10.1523/JNEUROSCI.0259-20.2020 |
identifier_str_mv |
RADISKE, Andressa; GONZALEZ, Maria Carolina; CONDE-OCAZIONEZ, Sergio; ROSSATO, Janine I.; KÖHLER, Cristiano A.; CAMMAROTA, Martín. Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption. The Journal of Neuroscience, [S.l.], jul. 2020. http://dx.doi.org/10.1523/jneurosci.0259-20.2020. Disponível em: https://www.jneurosci.org/content/early/2020/07/13/JNEUROSCI.0259-20.2020. Acesso em: 24 jul. 2020. 10.1523/JNEUROSCI.0259-20.2020 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/29719 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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Society for Neuroscience |
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Society for Neuroscience |
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