JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Maia, Lucas de Lima
Data de Publicação: 2018
Outros Autores: Peterle, Gabriela Tonini, Santos, Marcelo dos, Trivilin, Leonardo Oliveira, Mendes, Suzanny Oliveira, Oliveira, Mayara Mota de, Santos, Joaquim Gasparini dos, Stur, Elaine, Agostini, Lidiane Pignaton, Couto, Cinthia Vidal Monteiro da Silva, Dalbo, Juliana, Assis, Arícia Leone Evangelista Monteiro de, Archanjo, Anderson Barros, Mercante, Ana Maria Da Cunha, Lopez, Rossana Veronica Mendoza, Nunes, Fábio Daumas, Carvalho, Marcos Brasilino de, Tajara, Eloiza Helena, Louro, Iúri Drumond, Álvares-da-Silva, Adriana Madeira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/31330
Resumo: Aims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets
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spelling Maia, Lucas de LimaPeterle, Gabriela ToniniSantos, Marcelo dosTrivilin, Leonardo OliveiraMendes, Suzanny OliveiraOliveira, Mayara Mota deSantos, Joaquim Gasparini dosStur, ElaineAgostini, Lidiane PignatonCouto, Cinthia Vidal Monteiro da SilvaDalbo, JulianaAssis, Arícia Leone Evangelista Monteiro deArchanjo, Anderson BarrosMercante, Ana Maria Da CunhaLopez, Rossana Veronica MendozaNunes, Fábio DaumasCarvalho, Marcos Brasilino deTajara, Eloiza HelenaLouro, Iúri DrumondÁlvares-da-Silva, Adriana Madeira2021-02-02T10:48:19Z2021-02-02T10:48:19Z2018-03-28MAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884.1932-6203 (online)https://repositorio.ufrn.br/handle/123456789/3133010.1371/journal.pone.0194884Public Library of ScienceAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessCarcinoma, Squamous CellEpigenesis, GeneticLymphatic MetastasisMouth NeoplasmsNeoplasm Recurrence, LocalOropharyngeal NeoplasmsJMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targetsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31330/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31330/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALJmjd1aH3k9me1H3k9me2_Santos_2018.pdfJmjd1aH3k9me1H3k9me2_Santos_2018.pdfapplication/pdf11322137https://repositorio.ufrn.br/bitstream/123456789/31330/1/Jmjd1aH3k9me1H3k9me2_Santos_2018.pdf7895cc36560d4885f30452b66c2e8ea5MD51TEXTJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.txtJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.txtExtracted texttext/plain48134https://repositorio.ufrn.br/bitstream/123456789/31330/4/Jmjd1aH3k9me1H3k9me2_Santos_2018.pdf.txt671ed73d65b06fe21e8d1f9d676b7761MD54THUMBNAILJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.jpgJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.jpgGenerated Thumbnailimage/jpeg1785https://repositorio.ufrn.br/bitstream/123456789/31330/5/Jmjd1aH3k9me1H3k9me2_Santos_2018.pdf.jpg9e00ebc48ccf6681282ca8ac9648c9a3MD55123456789/313302021-03-15 08:37:53.743oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-03-15T11:37:53Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
title JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
spellingShingle JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
Maia, Lucas de Lima
Carcinoma, Squamous Cell
Epigenesis, Genetic
Lymphatic Metastasis
Mouth Neoplasms
Neoplasm Recurrence, Local
Oropharyngeal Neoplasms
title_short JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
title_full JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
title_fullStr JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
title_full_unstemmed JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
title_sort JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
author Maia, Lucas de Lima
author_facet Maia, Lucas de Lima
Peterle, Gabriela Tonini
Santos, Marcelo dos
Trivilin, Leonardo Oliveira
Mendes, Suzanny Oliveira
Oliveira, Mayara Mota de
Santos, Joaquim Gasparini dos
Stur, Elaine
Agostini, Lidiane Pignaton
Couto, Cinthia Vidal Monteiro da Silva
Dalbo, Juliana
Assis, Arícia Leone Evangelista Monteiro de
Archanjo, Anderson Barros
Mercante, Ana Maria Da Cunha
Lopez, Rossana Veronica Mendoza
Nunes, Fábio Daumas
Carvalho, Marcos Brasilino de
Tajara, Eloiza Helena
Louro, Iúri Drumond
Álvares-da-Silva, Adriana Madeira
author_role author
author2 Peterle, Gabriela Tonini
Santos, Marcelo dos
Trivilin, Leonardo Oliveira
Mendes, Suzanny Oliveira
Oliveira, Mayara Mota de
Santos, Joaquim Gasparini dos
Stur, Elaine
Agostini, Lidiane Pignaton
Couto, Cinthia Vidal Monteiro da Silva
Dalbo, Juliana
Assis, Arícia Leone Evangelista Monteiro de
Archanjo, Anderson Barros
Mercante, Ana Maria Da Cunha
Lopez, Rossana Veronica Mendoza
Nunes, Fábio Daumas
Carvalho, Marcos Brasilino de
Tajara, Eloiza Helena
Louro, Iúri Drumond
Álvares-da-Silva, Adriana Madeira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maia, Lucas de Lima
Peterle, Gabriela Tonini
Santos, Marcelo dos
Trivilin, Leonardo Oliveira
Mendes, Suzanny Oliveira
Oliveira, Mayara Mota de
Santos, Joaquim Gasparini dos
Stur, Elaine
Agostini, Lidiane Pignaton
Couto, Cinthia Vidal Monteiro da Silva
Dalbo, Juliana
Assis, Arícia Leone Evangelista Monteiro de
Archanjo, Anderson Barros
Mercante, Ana Maria Da Cunha
Lopez, Rossana Veronica Mendoza
Nunes, Fábio Daumas
Carvalho, Marcos Brasilino de
Tajara, Eloiza Helena
Louro, Iúri Drumond
Álvares-da-Silva, Adriana Madeira
dc.subject.por.fl_str_mv Carcinoma, Squamous Cell
Epigenesis, Genetic
Lymphatic Metastasis
Mouth Neoplasms
Neoplasm Recurrence, Local
Oropharyngeal Neoplasms
topic Carcinoma, Squamous Cell
Epigenesis, Genetic
Lymphatic Metastasis
Mouth Neoplasms
Neoplasm Recurrence, Local
Oropharyngeal Neoplasms
description Aims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets
publishDate 2018
dc.date.issued.fl_str_mv 2018-03-28
dc.date.accessioned.fl_str_mv 2021-02-02T10:48:19Z
dc.date.available.fl_str_mv 2021-02-02T10:48:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/31330
dc.identifier.issn.none.fl_str_mv 1932-6203 (online)
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0194884
identifier_str_mv MAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884.
1932-6203 (online)
10.1371/journal.pone.0194884
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