JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31330 |
Resumo: | Aims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets |
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Maia, Lucas de LimaPeterle, Gabriela ToniniSantos, Marcelo dosTrivilin, Leonardo OliveiraMendes, Suzanny OliveiraOliveira, Mayara Mota deSantos, Joaquim Gasparini dosStur, ElaineAgostini, Lidiane PignatonCouto, Cinthia Vidal Monteiro da SilvaDalbo, JulianaAssis, Arícia Leone Evangelista Monteiro deArchanjo, Anderson BarrosMercante, Ana Maria Da CunhaLopez, Rossana Veronica MendozaNunes, Fábio DaumasCarvalho, Marcos Brasilino deTajara, Eloiza HelenaLouro, Iúri DrumondÁlvares-da-Silva, Adriana Madeira2021-02-02T10:48:19Z2021-02-02T10:48:19Z2018-03-28MAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884.1932-6203 (online)https://repositorio.ufrn.br/handle/123456789/3133010.1371/journal.pone.0194884Public Library of ScienceAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessCarcinoma, Squamous CellEpigenesis, GeneticLymphatic MetastasisMouth NeoplasmsNeoplasm Recurrence, LocalOropharyngeal NeoplasmsJMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targetsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31330/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31330/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALJmjd1aH3k9me1H3k9me2_Santos_2018.pdfJmjd1aH3k9me1H3k9me2_Santos_2018.pdfapplication/pdf11322137https://repositorio.ufrn.br/bitstream/123456789/31330/1/Jmjd1aH3k9me1H3k9me2_Santos_2018.pdf7895cc36560d4885f30452b66c2e8ea5MD51TEXTJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.txtJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.txtExtracted texttext/plain48134https://repositorio.ufrn.br/bitstream/123456789/31330/4/Jmjd1aH3k9me1H3k9me2_Santos_2018.pdf.txt671ed73d65b06fe21e8d1f9d676b7761MD54THUMBNAILJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.jpgJmjd1aH3k9me1H3k9me2_Santos_2018.pdf.jpgGenerated Thumbnailimage/jpeg1785https://repositorio.ufrn.br/bitstream/123456789/31330/5/Jmjd1aH3k9me1H3k9me2_Santos_2018.pdf.jpg9e00ebc48ccf6681282ca8ac9648c9a3MD55123456789/313302021-03-15 08:37:53.743oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-03-15T11:37:53Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
title |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
spellingShingle |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma Maia, Lucas de Lima Carcinoma, Squamous Cell Epigenesis, Genetic Lymphatic Metastasis Mouth Neoplasms Neoplasm Recurrence, Local Oropharyngeal Neoplasms |
title_short |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
title_full |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
title_fullStr |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
title_full_unstemmed |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
title_sort |
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma |
author |
Maia, Lucas de Lima |
author_facet |
Maia, Lucas de Lima Peterle, Gabriela Tonini Santos, Marcelo dos Trivilin, Leonardo Oliveira Mendes, Suzanny Oliveira Oliveira, Mayara Mota de Santos, Joaquim Gasparini dos Stur, Elaine Agostini, Lidiane Pignaton Couto, Cinthia Vidal Monteiro da Silva Dalbo, Juliana Assis, Arícia Leone Evangelista Monteiro de Archanjo, Anderson Barros Mercante, Ana Maria Da Cunha Lopez, Rossana Veronica Mendoza Nunes, Fábio Daumas Carvalho, Marcos Brasilino de Tajara, Eloiza Helena Louro, Iúri Drumond Álvares-da-Silva, Adriana Madeira |
author_role |
author |
author2 |
Peterle, Gabriela Tonini Santos, Marcelo dos Trivilin, Leonardo Oliveira Mendes, Suzanny Oliveira Oliveira, Mayara Mota de Santos, Joaquim Gasparini dos Stur, Elaine Agostini, Lidiane Pignaton Couto, Cinthia Vidal Monteiro da Silva Dalbo, Juliana Assis, Arícia Leone Evangelista Monteiro de Archanjo, Anderson Barros Mercante, Ana Maria Da Cunha Lopez, Rossana Veronica Mendoza Nunes, Fábio Daumas Carvalho, Marcos Brasilino de Tajara, Eloiza Helena Louro, Iúri Drumond Álvares-da-Silva, Adriana Madeira |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maia, Lucas de Lima Peterle, Gabriela Tonini Santos, Marcelo dos Trivilin, Leonardo Oliveira Mendes, Suzanny Oliveira Oliveira, Mayara Mota de Santos, Joaquim Gasparini dos Stur, Elaine Agostini, Lidiane Pignaton Couto, Cinthia Vidal Monteiro da Silva Dalbo, Juliana Assis, Arícia Leone Evangelista Monteiro de Archanjo, Anderson Barros Mercante, Ana Maria Da Cunha Lopez, Rossana Veronica Mendoza Nunes, Fábio Daumas Carvalho, Marcos Brasilino de Tajara, Eloiza Helena Louro, Iúri Drumond Álvares-da-Silva, Adriana Madeira |
dc.subject.por.fl_str_mv |
Carcinoma, Squamous Cell Epigenesis, Genetic Lymphatic Metastasis Mouth Neoplasms Neoplasm Recurrence, Local Oropharyngeal Neoplasms |
topic |
Carcinoma, Squamous Cell Epigenesis, Genetic Lymphatic Metastasis Mouth Neoplasms Neoplasm Recurrence, Local Oropharyngeal Neoplasms |
description |
Aims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-03-28 |
dc.date.accessioned.fl_str_mv |
2021-02-02T10:48:19Z |
dc.date.available.fl_str_mv |
2021-02-02T10:48:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31330 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 (online) |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0194884 |
identifier_str_mv |
MAIA, Lucas de Lima; PETERLE, Gabriela Tonini; SANTOS, Marcelo dos; TRIVILIN, Leonardo Oliveira; MENDES, Suzanny Oliveira; OLIVEIRA, Mayara Mota de; SANTOS, Joaquim Gasparini dos; STUR, Elaine; AGOSTINI, Lidiane Pignaton; COUTO, Cinthia Vidal Monteiro da Silva; DALBO, Juliana; ASSIS, Aricia Leone Evangelista Monteiro de; ARCHANJO, Anderson Barros; MERCANTE, Ana Maria da Cunha; LOPEZ, Rossana Veronica Mendonza; NUNES, Fábio Daumas; CARVALHO, Marcos Brasilino de; TAJARA, Eloiza Helena; LOURO, Iúri Drumond Louro; ÁLVARES-DA-SILVA, Adriana Madeira. JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma. Plos One, [s. l.], v. 13, n. 3, p. 1-16, mar. 2018. Public Library of Science (PLoS). Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194884. Acesso em: 30 jun. 2020. http://dx.doi.org/10.1371/journal.pone.0194884. 1932-6203 (online) 10.1371/journal.pone.0194884 |
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https://repositorio.ufrn.br/handle/123456789/31330 |
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eng |
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eng |
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Public Library of Science |
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