"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/57641 |
Resumo: | Background: Chikungunya is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and can lead to neurological complications in severe cases. Objective: This study examined neuroimaging patterns in chikungunya cases during two outbreaks in Brazil to identify specific patterns for diagnosis and treatment of neuro-chikungunya. Methods: Eight patients with confirmed chikungunya and neurological involvement were included. Clinical examinations and MRI scans were performed, and findings were analyzed by neuroradiologists. Data on age, sex, neurological symptoms, diagnostic tests, MRI findings, and clinical outcomes were recorded. Results: Patients showed different neuroimaging patterns. Six patients exhibited a "clock dial pattern" with hyperintense dotted lesions in the spinal cord periphery. One patient had thickening and enhancement of anterior nerve roots. Brain MRI revealed multiple hyperintense lesions in the white matter, particularly in the medulla oblongata, in six patients. One patient had a normal brain MRI. Conclusion: The "clock dial pattern" observed in spinal cord MRI may be indicative of chikungunya-related nervous system lesions. Isolated involvement of spinal cord white matter in chikungunya can help differentiate it from other viral infections. Additionally, distinct brainstem involvement in chikungunya-associated encephalitis, particularly in the rostral region, sets it apart from other arboviral infections. Recognizing these neuroimaging patterns can contribute to early diagnosis and appropriate management of neuro-chikungunya |
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Fraiman, Pedro Henrique AlmeidaFreire, MarianaFernandes, BrunoMangueira, Felipe Palitot AlvesMota, Nathalia Louise Gomes do Rosario Alves daSequerra, Eduardo BouthSantos, Glauco Igor Viana dosDourado Junior, Mario Emilio TeixeiraGodeiro Júnior, Clécio de OliveiraMoreira-Neto, Manuel2024-02-19T14:13:57Z2024-02-19T14:13:57Z2024-01FRAIMAN, Pedro Henrique Almeida; FREIRE, Mariana; FERNANDES, Bruno; PALITOT, Felipe; MOTA, Nathalia; SEQUERRA, Eduardo; SANTOS, Glauco; DOURADO, Mario Emilio; GODEIRO-JUNIOR, Clecio de Oliveira; MOREIRA-NETO, Manuel. “Clock dial pattern”, a radiologic clue to neuro-chikungunya diagnosis: a case series. Arquivos de Neuro-Psiquiatria, [S. l.], v. 82, n. 1, p. 01-06, jan. 2024. Doi: http://dx.doi.org/10.1055/s-0044-1779033. Disponível em: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-1779033. Acesso em: 16 fev. 2024https://repositorio.ufrn.br/handle/123456789/5764110.1055/s-0044-1779033Georg Thieme Verlag KGAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessChikungunya virusMyelitisArbovirus infections - Diagnostic imagingNeuro-chikungunya"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: Chikungunya is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and can lead to neurological complications in severe cases. Objective: This study examined neuroimaging patterns in chikungunya cases during two outbreaks in Brazil to identify specific patterns for diagnosis and treatment of neuro-chikungunya. Methods: Eight patients with confirmed chikungunya and neurological involvement were included. Clinical examinations and MRI scans were performed, and findings were analyzed by neuroradiologists. Data on age, sex, neurological symptoms, diagnostic tests, MRI findings, and clinical outcomes were recorded. Results: Patients showed different neuroimaging patterns. Six patients exhibited a "clock dial pattern" with hyperintense dotted lesions in the spinal cord periphery. One patient had thickening and enhancement of anterior nerve roots. Brain MRI revealed multiple hyperintense lesions in the white matter, particularly in the medulla oblongata, in six patients. One patient had a normal brain MRI. Conclusion: The "clock dial pattern" observed in spinal cord MRI may be indicative of chikungunya-related nervous system lesions. Isolated involvement of spinal cord white matter in chikungunya can help differentiate it from other viral infections. Additionally, distinct brainstem involvement in chikungunya-associated encephalitis, particularly in the rostral region, sets it apart from other arboviral infections. Recognizing these neuroimaging patterns can contribute to early diagnosis and appropriate management of neuro-chikungunyaengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALClockDialPattern_Sequerra_2024.pdfClockDialPattern_Sequerra_2024.pdfClockDialPattern_Sequerra_2024application/pdf998322https://repositorio.ufrn.br/bitstream/123456789/57641/1/ClockDialPattern_Sequerra_2024.pdf1db918267154794a9812573faee9380dMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/57641/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/57641/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/576412024-02-19 11:13:58.379oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-02-19T14:13:58Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
title |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
spellingShingle |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series Fraiman, Pedro Henrique Almeida Chikungunya virus Myelitis Arbovirus infections - Diagnostic imaging Neuro-chikungunya |
title_short |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
title_full |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
title_fullStr |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
title_full_unstemmed |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
title_sort |
"Clock dial pattern", a radiologic clue to neuro-chikungunya diagnosis: a case series |
author |
Fraiman, Pedro Henrique Almeida |
author_facet |
Fraiman, Pedro Henrique Almeida Freire, Mariana Fernandes, Bruno Mangueira, Felipe Palitot Alves Mota, Nathalia Louise Gomes do Rosario Alves da Sequerra, Eduardo Bouth Santos, Glauco Igor Viana dos Dourado Junior, Mario Emilio Teixeira Godeiro Júnior, Clécio de Oliveira Moreira-Neto, Manuel |
author_role |
author |
author2 |
Freire, Mariana Fernandes, Bruno Mangueira, Felipe Palitot Alves Mota, Nathalia Louise Gomes do Rosario Alves da Sequerra, Eduardo Bouth Santos, Glauco Igor Viana dos Dourado Junior, Mario Emilio Teixeira Godeiro Júnior, Clécio de Oliveira Moreira-Neto, Manuel |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fraiman, Pedro Henrique Almeida Freire, Mariana Fernandes, Bruno Mangueira, Felipe Palitot Alves Mota, Nathalia Louise Gomes do Rosario Alves da Sequerra, Eduardo Bouth Santos, Glauco Igor Viana dos Dourado Junior, Mario Emilio Teixeira Godeiro Júnior, Clécio de Oliveira Moreira-Neto, Manuel |
dc.subject.por.fl_str_mv |
Chikungunya virus Myelitis Arbovirus infections - Diagnostic imaging Neuro-chikungunya |
topic |
Chikungunya virus Myelitis Arbovirus infections - Diagnostic imaging Neuro-chikungunya |
description |
Background: Chikungunya is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and can lead to neurological complications in severe cases. Objective: This study examined neuroimaging patterns in chikungunya cases during two outbreaks in Brazil to identify specific patterns for diagnosis and treatment of neuro-chikungunya. Methods: Eight patients with confirmed chikungunya and neurological involvement were included. Clinical examinations and MRI scans were performed, and findings were analyzed by neuroradiologists. Data on age, sex, neurological symptoms, diagnostic tests, MRI findings, and clinical outcomes were recorded. Results: Patients showed different neuroimaging patterns. Six patients exhibited a "clock dial pattern" with hyperintense dotted lesions in the spinal cord periphery. One patient had thickening and enhancement of anterior nerve roots. Brain MRI revealed multiple hyperintense lesions in the white matter, particularly in the medulla oblongata, in six patients. One patient had a normal brain MRI. Conclusion: The "clock dial pattern" observed in spinal cord MRI may be indicative of chikungunya-related nervous system lesions. Isolated involvement of spinal cord white matter in chikungunya can help differentiate it from other viral infections. Additionally, distinct brainstem involvement in chikungunya-associated encephalitis, particularly in the rostral region, sets it apart from other arboviral infections. Recognizing these neuroimaging patterns can contribute to early diagnosis and appropriate management of neuro-chikungunya |
publishDate |
2024 |
dc.date.accessioned.fl_str_mv |
2024-02-19T14:13:57Z |
dc.date.available.fl_str_mv |
2024-02-19T14:13:57Z |
dc.date.issued.fl_str_mv |
2024-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FRAIMAN, Pedro Henrique Almeida; FREIRE, Mariana; FERNANDES, Bruno; PALITOT, Felipe; MOTA, Nathalia; SEQUERRA, Eduardo; SANTOS, Glauco; DOURADO, Mario Emilio; GODEIRO-JUNIOR, Clecio de Oliveira; MOREIRA-NETO, Manuel. “Clock dial pattern”, a radiologic clue to neuro-chikungunya diagnosis: a case series. Arquivos de Neuro-Psiquiatria, [S. l.], v. 82, n. 1, p. 01-06, jan. 2024. Doi: http://dx.doi.org/10.1055/s-0044-1779033. Disponível em: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-1779033. Acesso em: 16 fev. 2024 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/57641 |
dc.identifier.doi.none.fl_str_mv |
10.1055/s-0044-1779033 |
identifier_str_mv |
FRAIMAN, Pedro Henrique Almeida; FREIRE, Mariana; FERNANDES, Bruno; PALITOT, Felipe; MOTA, Nathalia; SEQUERRA, Eduardo; SANTOS, Glauco; DOURADO, Mario Emilio; GODEIRO-JUNIOR, Clecio de Oliveira; MOREIRA-NETO, Manuel. “Clock dial pattern”, a radiologic clue to neuro-chikungunya diagnosis: a case series. Arquivos de Neuro-Psiquiatria, [S. l.], v. 82, n. 1, p. 01-06, jan. 2024. Doi: http://dx.doi.org/10.1055/s-0044-1779033. Disponível em: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-1779033. Acesso em: 16 fev. 2024 10.1055/s-0044-1779033 |
url |
https://repositorio.ufrn.br/handle/123456789/57641 |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Georg Thieme Verlag KG |
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Georg Thieme Verlag KG |
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