Hippocampal and cortical communication around micro-arousals in slow-wave sleep
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/30823 |
Resumo: | Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6–12 Hz) to Delta (2–4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5–7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during τ interval in a broader frequency band (2–12 Hz), while at a lower frequency band (0.5–2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture |
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Lima, Gustavo Zampier dos SantosLobão-Soares, BrunoCorso, GilbertoBelchior, Hindiael AerafLopes, Sergio Roberto LopesPrado, Thiago de LimaNascimento, George Carlos doAraújo, John FonteneleIvanov, Plamen Ch.2020-12-04T19:23:10Z2020-12-04T19:23:10Z2019-04-10LIMA, Gustavo Zampier dos Santos; LOBAO-SOARES, Bruno; CORSO, Gilberto; BELCHIOR, Hindiael; LOPES, Sergio Roberto; PRADO, Thiago de Lima; NASCIMENTO, George; FRANÇA, Arthur Cavalcanti de; FONTENELE-ARAÚJO, John; IVANOV, Plamen Ch.. Hippocampal and cortical communication around micro-arousals in slow-wave sleep. Scientific Reports, [S.L.], v. 9, n. 1, p. 5876-5876, 10 abr. 2019. Disponível em: https://www.nature.com/articles/s41598-019-42100-5. Acesso em: 20 nov. 2020. http://dx.doi.org/10.1038/s41598-019-42100-5.1678-765Xhttps://repositorio.ufrn.br/handle/123456789/3082310.1038/s41598-019-42100-5Nature Publishing GroupAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessNeural circuitsNeurophysiologyHippocampal and cortical communication around micro-arousals in slow-wave sleepinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6–12 Hz) to Delta (2–4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5–7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during τ interval in a broader frequency band (2–12 Hz), while at a lower frequency band (0.5–2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architectureengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALHippocampalCortical_Lima_2019.pdfHippocampalCortical_Lima_2019.pdfArtigoapplication/pdf3453551https://repositorio.ufrn.br/bitstream/123456789/30823/1/HippocampalCortical_Lima_2019.pdfdfb9a54ee9cb14de089b4d76adc9911aMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/30823/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/30823/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTHippocampalCortical_LIMA_2019.pdf.txtHippocampalCortical_LIMA_2019.pdf.txtExtracted texttext/plain66031https://repositorio.ufrn.br/bitstream/123456789/30823/4/HippocampalCortical_LIMA_2019.pdf.txtbdd8adf354d842937bd77a171005ca15MD54THUMBNAILHippocampalCortical_LIMA_2019.pdf.jpgHippocampalCortical_LIMA_2019.pdf.jpgGenerated Thumbnailimage/jpeg1890https://repositorio.ufrn.br/bitstream/123456789/30823/5/HippocampalCortical_LIMA_2019.pdf.jpg8aa67d010bac835da4efa07a43e50c8bMD55123456789/308232021-11-10 15:38:06.524oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-10T18:38:06Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
title |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
spellingShingle |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep Lima, Gustavo Zampier dos Santos Neural circuits Neurophysiology |
title_short |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
title_full |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
title_fullStr |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
title_full_unstemmed |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
title_sort |
Hippocampal and cortical communication around micro-arousals in slow-wave sleep |
author |
Lima, Gustavo Zampier dos Santos |
author_facet |
Lima, Gustavo Zampier dos Santos Lobão-Soares, Bruno Corso, Gilberto Belchior, Hindiael Aeraf Lopes, Sergio Roberto Lopes Prado, Thiago de Lima Nascimento, George Carlos do Araújo, John Fontenele Ivanov, Plamen Ch. |
author_role |
author |
author2 |
Lobão-Soares, Bruno Corso, Gilberto Belchior, Hindiael Aeraf Lopes, Sergio Roberto Lopes Prado, Thiago de Lima Nascimento, George Carlos do Araújo, John Fontenele Ivanov, Plamen Ch. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Gustavo Zampier dos Santos Lobão-Soares, Bruno Corso, Gilberto Belchior, Hindiael Aeraf Lopes, Sergio Roberto Lopes Prado, Thiago de Lima Nascimento, George Carlos do Araújo, John Fontenele Ivanov, Plamen Ch. |
dc.subject.por.fl_str_mv |
Neural circuits Neurophysiology |
topic |
Neural circuits Neurophysiology |
description |
Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6–12 Hz) to Delta (2–4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5–7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during τ interval in a broader frequency band (2–12 Hz), while at a lower frequency band (0.5–2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-04-10 |
dc.date.accessioned.fl_str_mv |
2020-12-04T19:23:10Z |
dc.date.available.fl_str_mv |
2020-12-04T19:23:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIMA, Gustavo Zampier dos Santos; LOBAO-SOARES, Bruno; CORSO, Gilberto; BELCHIOR, Hindiael; LOPES, Sergio Roberto; PRADO, Thiago de Lima; NASCIMENTO, George; FRANÇA, Arthur Cavalcanti de; FONTENELE-ARAÚJO, John; IVANOV, Plamen Ch.. Hippocampal and cortical communication around micro-arousals in slow-wave sleep. Scientific Reports, [S.L.], v. 9, n. 1, p. 5876-5876, 10 abr. 2019. Disponível em: https://www.nature.com/articles/s41598-019-42100-5. Acesso em: 20 nov. 2020. http://dx.doi.org/10.1038/s41598-019-42100-5. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/30823 |
dc.identifier.issn.none.fl_str_mv |
1678-765X |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-019-42100-5 |
identifier_str_mv |
LIMA, Gustavo Zampier dos Santos; LOBAO-SOARES, Bruno; CORSO, Gilberto; BELCHIOR, Hindiael; LOPES, Sergio Roberto; PRADO, Thiago de Lima; NASCIMENTO, George; FRANÇA, Arthur Cavalcanti de; FONTENELE-ARAÚJO, John; IVANOV, Plamen Ch.. Hippocampal and cortical communication around micro-arousals in slow-wave sleep. Scientific Reports, [S.L.], v. 9, n. 1, p. 5876-5876, 10 abr. 2019. Disponível em: https://www.nature.com/articles/s41598-019-42100-5. Acesso em: 20 nov. 2020. http://dx.doi.org/10.1038/s41598-019-42100-5. 1678-765X 10.1038/s41598-019-42100-5 |
url |
https://repositorio.ufrn.br/handle/123456789/30823 |
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eng |
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eng |
dc.rights.driver.fl_str_mv |
Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
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Nature Publishing Group |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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