Recognition memory reconsolidation requires hippocampal Zif268

Detalhes bibliográficos
Autor(a) principal: Gonzalez, Maria Carolina
Data de Publicação: 2019
Outros Autores: Rossato, Janine I., Radiske, Andressa, Reis, Marina Pádua, Cammarota, Martín Pablo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/28209
Resumo: Object recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.
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spelling Gonzalez, Maria CarolinaRossato, Janine I.Radiske, AndressaReis, Marina PáduaCammarota, Martín Pablo2019-12-18T15:14:06Z2019-12-18T15:14:06Z2019-11-12GONZALEZ, M. C.; ROSSATO, J. I.; RADISKE, A.; REIS, M. P.; CAMMAROTA, M. Recognition memory reconsolidation requires hippocampal Zif268. Sci Rep., [s. l.], v. 9, p. 16620, nov. 2019. Doi: 10.1038/s41598-019-53005-8. Disponível em: https://www-ncbi-nlm-nih-gov.ez18.periodicos.capes.gov.br/pmc/articles/PMC6851087/. Acesso em: 18 dez. 2019.https://repositorio.ufrn.br/jspui/handle/123456789/2820910.1038/s41598-019-53005-8NeurophysiologyLearning and memoryRecognition memory reconsolidation requires hippocampal Zif268info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObject recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/28209/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52ORIGINALMartinCammarota_ICe_2019_Recognition memory.pdfMartinCammarota_ICe_2019_Recognition memory.pdfMartinCammarota_ICe_2019_Recognition memoryapplication/pdf2895646https://repositorio.ufrn.br/bitstream/123456789/28209/1/MartinCammarota_ICe_2019_Recognition%20memory.pdf3afea365b8345b4514d5573c68920c72MD51TEXTMartinCammarota_ICe_2019_Recognition memory.pdf.txtMartinCammarota_ICe_2019_Recognition memory.pdf.txtExtracted texttext/plain52889https://repositorio.ufrn.br/bitstream/123456789/28209/3/MartinCammarota_ICe_2019_Recognition%20memory.pdf.txt9e3e3ce3358b386ffddd69b6a9a4b32bMD53THUMBNAILMartinCammarota_ICe_2019_Recognition memory.pdf.jpgMartinCammarota_ICe_2019_Recognition memory.pdf.jpgGenerated Thumbnailimage/jpeg1723https://repositorio.ufrn.br/bitstream/123456789/28209/4/MartinCammarota_ICe_2019_Recognition%20memory.pdf.jpg0bffb98c53a091d4b45e74a1ec9ab01dMD54123456789/282092021-07-09 18:07:40.701oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T21:07:40Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Recognition memory reconsolidation requires hippocampal Zif268
title Recognition memory reconsolidation requires hippocampal Zif268
spellingShingle Recognition memory reconsolidation requires hippocampal Zif268
Gonzalez, Maria Carolina
Neurophysiology
Learning and memory
title_short Recognition memory reconsolidation requires hippocampal Zif268
title_full Recognition memory reconsolidation requires hippocampal Zif268
title_fullStr Recognition memory reconsolidation requires hippocampal Zif268
title_full_unstemmed Recognition memory reconsolidation requires hippocampal Zif268
title_sort Recognition memory reconsolidation requires hippocampal Zif268
author Gonzalez, Maria Carolina
author_facet Gonzalez, Maria Carolina
Rossato, Janine I.
Radiske, Andressa
Reis, Marina Pádua
Cammarota, Martín Pablo
author_role author
author2 Rossato, Janine I.
Radiske, Andressa
Reis, Marina Pádua
Cammarota, Martín Pablo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gonzalez, Maria Carolina
Rossato, Janine I.
Radiske, Andressa
Reis, Marina Pádua
Cammarota, Martín Pablo
dc.subject.por.fl_str_mv Neurophysiology
Learning and memory
topic Neurophysiology
Learning and memory
description Object recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-12-18T15:14:06Z
dc.date.available.fl_str_mv 2019-12-18T15:14:06Z
dc.date.issued.fl_str_mv 2019-11-12
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv GONZALEZ, M. C.; ROSSATO, J. I.; RADISKE, A.; REIS, M. P.; CAMMAROTA, M. Recognition memory reconsolidation requires hippocampal Zif268. Sci Rep., [s. l.], v. 9, p. 16620, nov. 2019. Doi: 10.1038/s41598-019-53005-8. Disponível em: https://www-ncbi-nlm-nih-gov.ez18.periodicos.capes.gov.br/pmc/articles/PMC6851087/. Acesso em: 18 dez. 2019.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/28209
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-019-53005-8
identifier_str_mv GONZALEZ, M. C.; ROSSATO, J. I.; RADISKE, A.; REIS, M. P.; CAMMAROTA, M. Recognition memory reconsolidation requires hippocampal Zif268. Sci Rep., [s. l.], v. 9, p. 16620, nov. 2019. Doi: 10.1038/s41598-019-53005-8. Disponível em: https://www-ncbi-nlm-nih-gov.ez18.periodicos.capes.gov.br/pmc/articles/PMC6851087/. Acesso em: 18 dez. 2019.
10.1038/s41598-019-53005-8
url https://repositorio.ufrn.br/jspui/handle/123456789/28209
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