OLMα2 cells bidirectionally modulate learning
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25586 https://doi.org/10.1016/j.neuron.2018.06.022 |
Resumo: | Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMα2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMα2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMα2 cell activation inhibits fear-related memories and that OLMα2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMα2 cells are an important component in the CA1 microcircuit regulating learning and memory processes. |
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Siwani, SamerFrança, Arthur S. C.Mikulovic, SanjaReis, AmilcarHilscher, Markus M.Edwards, Steven J.Leão, Richardson NavesTort, Adriano Bretanha LopesKullander, Klas2018-07-11T16:30:36Z2018-07-11T16:30:36Z2018-07SIWANI, S. et al. OLMa2 cells bidirectionally modulate learning, Neuron, v. 99, n.1, jul./2018.https://repositorio.ufrn.br/jspui/handle/123456789/25586https://doi.org/10.1016/j.neuron.2018.06.022engOLM cellsobject recognitionpassive inhibitory avoidancememoryOLMα2 cells bidirectionally modulate learninginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMα2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMα2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMα2 cell activation inhibits fear-related memories and that OLMα2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMα2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdfRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdfRichardsonLeao_ICe_2018_OLMa2 cells bidirectionallyapplication/pdf2497027https://repositorio.ufrn.br/bitstream/123456789/25586/1/RichardsonLeao_ICe_2018_OLMa2%20cells%20bidirectionally.pdfbdb16e01de802fb67a36d6d3c9705590MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25586/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdf.txtRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdf.txtExtracted texttext/plain59075https://repositorio.ufrn.br/bitstream/123456789/25586/3/RichardsonLeao_ICe_2018_OLMa2%20cells%20bidirectionally.pdf.txtbda38db141085ee737c704feb44e079bMD53THUMBNAILRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdf.jpgRichardsonLeao_ICe_2018_OLMa2 cells bidirectionally.pdf.jpgIM Thumbnailimage/jpeg7483https://repositorio.ufrn.br/bitstream/123456789/25586/4/RichardsonLeao_ICe_2018_OLMa2%20cells%20bidirectionally.pdf.jpge5a68e2d566a55dde783beb765cc766dMD54123456789/255862021-07-09 18:21:54.231oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T21:21:54Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
OLMα2 cells bidirectionally modulate learning |
title |
OLMα2 cells bidirectionally modulate learning |
spellingShingle |
OLMα2 cells bidirectionally modulate learning Siwani, Samer OLM cells object recognition passive inhibitory avoidance memory |
title_short |
OLMα2 cells bidirectionally modulate learning |
title_full |
OLMα2 cells bidirectionally modulate learning |
title_fullStr |
OLMα2 cells bidirectionally modulate learning |
title_full_unstemmed |
OLMα2 cells bidirectionally modulate learning |
title_sort |
OLMα2 cells bidirectionally modulate learning |
author |
Siwani, Samer |
author_facet |
Siwani, Samer França, Arthur S. C. Mikulovic, Sanja Reis, Amilcar Hilscher, Markus M. Edwards, Steven J. Leão, Richardson Naves Tort, Adriano Bretanha Lopes Kullander, Klas |
author_role |
author |
author2 |
França, Arthur S. C. Mikulovic, Sanja Reis, Amilcar Hilscher, Markus M. Edwards, Steven J. Leão, Richardson Naves Tort, Adriano Bretanha Lopes Kullander, Klas |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Siwani, Samer França, Arthur S. C. Mikulovic, Sanja Reis, Amilcar Hilscher, Markus M. Edwards, Steven J. Leão, Richardson Naves Tort, Adriano Bretanha Lopes Kullander, Klas |
dc.subject.por.fl_str_mv |
OLM cells object recognition passive inhibitory avoidance memory |
topic |
OLM cells object recognition passive inhibitory avoidance memory |
description |
Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMα2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMα2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMα2 cell activation inhibits fear-related memories and that OLMα2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMα2 cells are an important component in the CA1 microcircuit regulating learning and memory processes. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-07-11T16:30:36Z |
dc.date.available.fl_str_mv |
2018-07-11T16:30:36Z |
dc.date.issued.fl_str_mv |
2018-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SIWANI, S. et al. OLMa2 cells bidirectionally modulate learning, Neuron, v. 99, n.1, jul./2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/25586 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.neuron.2018.06.022 |
identifier_str_mv |
SIWANI, S. et al. OLMa2 cells bidirectionally modulate learning, Neuron, v. 99, n.1, jul./2018. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/25586 https://doi.org/10.1016/j.neuron.2018.06.022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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