Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

Detalhes bibliográficos
Autor(a) principal: Mikulovic, Sanja
Data de Publicação: 2018
Outros Autores: Restrepo, Carlos Ernesto, Siwani, Samer, Bauer, Pavol, Pupe, Stefano, Tort, Adriano Bretanha Lopes, Kullander, Klas, Leão, Richardson Naves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/25830
Resumo: Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.
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spelling Mikulovic, SanjaRestrepo, Carlos ErnestoSiwani, SamerBauer, PavolPupe, StefanoTort, Adriano Bretanha LopesKullander, KlasLeão, Richardson Naves2018-09-13T14:01:19Z2018-09-13T14:01:19Z2018-09https://repositorio.ufrn.br/jspui/handle/123456789/2583010.1038/s41467-018-05907-wengVentral hippocampalOLMtheta oscillationsVentral hippocampal OLM cells control type 2 theta oscillations and response to predator odorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALRichardsonLeao_ICe_2018_Ventral.pdfRichardsonLeao_ICe_2018_Ventral.pdfapplication/pdf7802805https://repositorio.ufrn.br/bitstream/123456789/25830/1/RichardsonLeao_ICe_2018_Ventral.pdf28909c47021261f44833bd28f2aa1b6dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25830/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTRichardsonLeao_ICe_2018_Ventral.pdf.txtRichardsonLeao_ICe_2018_Ventral.pdf.txtExtracted texttext/plain82402https://repositorio.ufrn.br/bitstream/123456789/25830/3/RichardsonLeao_ICe_2018_Ventral.pdf.txtaa8498d51ee1f1fec6964e8e9afd41a4MD53THUMBNAILRichardsonLeao_ICe_2018_Ventral.pdf.jpgRichardsonLeao_ICe_2018_Ventral.pdf.jpgIM Thumbnailimage/jpeg8918https://repositorio.ufrn.br/bitstream/123456789/25830/4/RichardsonLeao_ICe_2018_Ventral.pdf.jpgb02228b7cc1425be532668342118dc0dMD54TEXTRichardsonLeao_ICe_2018_Ventral.pdf.txtRichardsonLeao_ICe_2018_Ventral.pdf.txtExtracted texttext/plain82402https://repositorio.ufrn.br/bitstream/123456789/25830/3/RichardsonLeao_ICe_2018_Ventral.pdf.txtaa8498d51ee1f1fec6964e8e9afd41a4MD53THUMBNAILRichardsonLeao_ICe_2018_Ventral.pdf.jpgRichardsonLeao_ICe_2018_Ventral.pdf.jpgIM Thumbnailimage/jpeg8918https://repositorio.ufrn.br/bitstream/123456789/25830/4/RichardsonLeao_ICe_2018_Ventral.pdf.jpgb02228b7cc1425be532668342118dc0dMD54123456789/258302021-07-09 18:24:30.514oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T21:24:30Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
title Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
spellingShingle Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
Mikulovic, Sanja
Ventral hippocampal
OLM
theta oscillations
title_short Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
title_full Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
title_fullStr Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
title_full_unstemmed Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
title_sort Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
author Mikulovic, Sanja
author_facet Mikulovic, Sanja
Restrepo, Carlos Ernesto
Siwani, Samer
Bauer, Pavol
Pupe, Stefano
Tort, Adriano Bretanha Lopes
Kullander, Klas
Leão, Richardson Naves
author_role author
author2 Restrepo, Carlos Ernesto
Siwani, Samer
Bauer, Pavol
Pupe, Stefano
Tort, Adriano Bretanha Lopes
Kullander, Klas
Leão, Richardson Naves
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mikulovic, Sanja
Restrepo, Carlos Ernesto
Siwani, Samer
Bauer, Pavol
Pupe, Stefano
Tort, Adriano Bretanha Lopes
Kullander, Klas
Leão, Richardson Naves
dc.subject.por.fl_str_mv Ventral hippocampal
OLM
theta oscillations
topic Ventral hippocampal
OLM
theta oscillations
description Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-13T14:01:19Z
dc.date.available.fl_str_mv 2018-09-13T14:01:19Z
dc.date.issued.fl_str_mv 2018-09
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/25830
dc.identifier.doi.none.fl_str_mv 10.1038/s41467-018-05907-w
url https://repositorio.ufrn.br/jspui/handle/123456789/25830
identifier_str_mv 10.1038/s41467-018-05907-w
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
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institution UFRN
reponame_str Repositório Institucional da UFRN
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