Hypervascular liver lesions in radiologically normal liver
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54987 https://doi.org/10.1590/0102-6720201700010007 |
Resumo: | Background: The hypervascular liver lesions represent a diagnostic challenge. Aim: To identify risk factors for cancer in patients with non-hemangiomatous hypervascular hepatic lesions in radiologically normal liver. Method: This prospective study included patients with hypervascular liver lesions in radiologically normal liver. The diagnosis was made by biopsy or was presumed on the basis of radiologic stability in follow-up period of one year. Cirrhosis or patients with typical imaging characteristics of haemangioma were excluded. Results: Eightyeight patients were included. The average age was 42.4. The lesions were unique and were between 2-5 cm in size in most cases. Liver biopsy was performed in approximately 1/3 of cases. The lesions were benign or most likely benign in 81.8%, while cancer was diagnosed in 12.5% of cases. Univariate analysis showed that age >45 years (p< 0.001), personal history of cancer (p=0.020), presence of >3 nodules (p=0.003) and elevated alkaline phosphatase (p=0.013) were significant risk factors for cancer. Conclusion: It is safe to observe hypervascular liver lesions in normal liver in patients up to 45 years, normal alanine aminotransaminase, up to three nodules and no personal history of cancer. Lesion biopsies are safe in patients with atypical lesions and define the treatment to be established for most of these patients |
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Souza, Dyego Leandro Bezerra deAmico, Enio CamposAlves, José RobertoSalviano, Fellipe Alexandre MacenaJoão, Samir Assihttps://orcid.org/0000-0001-8426-31202023-10-16T17:02:01Z2023-10-16T17:02:01Z2017SOUZA, Dyego Leandro Bezerra de; AMICO, Enio Campos; ALVES, José Roberto; SALVIANO, Fellipe Alexandre Macena; JOÃO, Samir Assi; LIGUORI, Adriano de Araújo Lima. Hypervascular liver lesions in radiologically normal liver. Abcd. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), [S.L.], v. 30, n. 1, p. 21-26, mar. 2017. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/0102-6720201700010007. Disponível em: https://www.scielo.br/j/abcd/a/wR49xbttqRxXTmmBrcBjBLy/?lang=en. Acesso em: 22 set. 2023.https://repositorio.ufrn.br/handle/123456789/54987https://doi.org/10.1590/0102-6720201700010007FapUNIFESP (SciELO)Attribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessdiagnosisliver neoplasmsfocal nodular hyperplasiaadenomaliver cell neoplasmmetastasisdiagnósticometástaseneoplasias hepáticashiperplasia nodular focaladenoma hepáticoHypervascular liver lesions in radiologically normal liverLesão hepática hipervascular em fígado radiologicamente normalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: The hypervascular liver lesions represent a diagnostic challenge. Aim: To identify risk factors for cancer in patients with non-hemangiomatous hypervascular hepatic lesions in radiologically normal liver. Method: This prospective study included patients with hypervascular liver lesions in radiologically normal liver. The diagnosis was made by biopsy or was presumed on the basis of radiologic stability in follow-up period of one year. Cirrhosis or patients with typical imaging characteristics of haemangioma were excluded. Results: Eightyeight patients were included. The average age was 42.4. The lesions were unique and were between 2-5 cm in size in most cases. Liver biopsy was performed in approximately 1/3 of cases. The lesions were benign or most likely benign in 81.8%, while cancer was diagnosed in 12.5% of cases. Univariate analysis showed that age >45 years (p< 0.001), personal history of cancer (p=0.020), presence of >3 nodules (p=0.003) and elevated alkaline phosphatase (p=0.013) were significant risk factors for cancer. Conclusion: It is safe to observe hypervascular liver lesions in normal liver in patients up to 45 years, normal alanine aminotransaminase, up to three nodules and no personal history of cancer. Lesion biopsies are safe in patients with atypical lesions and define the treatment to be established for most of these patientsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALHypervascularLiverLesions_Souza_2017.pdfHypervascularLiverLesions_Souza_2017.pdfapplication/pdf582413https://repositorio.ufrn.br/bitstream/123456789/54987/1/HypervascularLiverLesions_Souza_2017.pdfc90bd3797b7dfccc98d6e60a081fa96bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/54987/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54987/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/549872023-10-16 14:02:03.188oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-10-16T17:02:03Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Hypervascular liver lesions in radiologically normal liver |
dc.title.alternative.pt_BR.fl_str_mv |
Lesão hepática hipervascular em fígado radiologicamente normal |
title |
Hypervascular liver lesions in radiologically normal liver |
spellingShingle |
Hypervascular liver lesions in radiologically normal liver Souza, Dyego Leandro Bezerra de diagnosis liver neoplasms focal nodular hyperplasia adenoma liver cell neoplasm metastasis diagnóstico metástase neoplasias hepáticas hiperplasia nodular focal adenoma hepático |
title_short |
Hypervascular liver lesions in radiologically normal liver |
title_full |
Hypervascular liver lesions in radiologically normal liver |
title_fullStr |
Hypervascular liver lesions in radiologically normal liver |
title_full_unstemmed |
Hypervascular liver lesions in radiologically normal liver |
title_sort |
Hypervascular liver lesions in radiologically normal liver |
author |
Souza, Dyego Leandro Bezerra de |
author_facet |
Souza, Dyego Leandro Bezerra de Amico, Enio Campos Alves, José Roberto Salviano, Fellipe Alexandre Macena João, Samir Assi |
author_role |
author |
author2 |
Amico, Enio Campos Alves, José Roberto Salviano, Fellipe Alexandre Macena João, Samir Assi |
author2_role |
author author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-8426-3120 |
dc.contributor.author.fl_str_mv |
Souza, Dyego Leandro Bezerra de Amico, Enio Campos Alves, José Roberto Salviano, Fellipe Alexandre Macena João, Samir Assi |
dc.subject.por.fl_str_mv |
diagnosis liver neoplasms focal nodular hyperplasia adenoma liver cell neoplasm metastasis diagnóstico metástase neoplasias hepáticas hiperplasia nodular focal adenoma hepático |
topic |
diagnosis liver neoplasms focal nodular hyperplasia adenoma liver cell neoplasm metastasis diagnóstico metástase neoplasias hepáticas hiperplasia nodular focal adenoma hepático |
description |
Background: The hypervascular liver lesions represent a diagnostic challenge. Aim: To identify risk factors for cancer in patients with non-hemangiomatous hypervascular hepatic lesions in radiologically normal liver. Method: This prospective study included patients with hypervascular liver lesions in radiologically normal liver. The diagnosis was made by biopsy or was presumed on the basis of radiologic stability in follow-up period of one year. Cirrhosis or patients with typical imaging characteristics of haemangioma were excluded. Results: Eightyeight patients were included. The average age was 42.4. The lesions were unique and were between 2-5 cm in size in most cases. Liver biopsy was performed in approximately 1/3 of cases. The lesions were benign or most likely benign in 81.8%, while cancer was diagnosed in 12.5% of cases. Univariate analysis showed that age >45 years (p< 0.001), personal history of cancer (p=0.020), presence of >3 nodules (p=0.003) and elevated alkaline phosphatase (p=0.013) were significant risk factors for cancer. Conclusion: It is safe to observe hypervascular liver lesions in normal liver in patients up to 45 years, normal alanine aminotransaminase, up to three nodules and no personal history of cancer. Lesion biopsies are safe in patients with atypical lesions and define the treatment to be established for most of these patients |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2023-10-16T17:02:01Z |
dc.date.available.fl_str_mv |
2023-10-16T17:02:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, Dyego Leandro Bezerra de; AMICO, Enio Campos; ALVES, José Roberto; SALVIANO, Fellipe Alexandre Macena; JOÃO, Samir Assi; LIGUORI, Adriano de Araújo Lima. Hypervascular liver lesions in radiologically normal liver. Abcd. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), [S.L.], v. 30, n. 1, p. 21-26, mar. 2017. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/0102-6720201700010007. Disponível em: https://www.scielo.br/j/abcd/a/wR49xbttqRxXTmmBrcBjBLy/?lang=en. Acesso em: 22 set. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54987 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1590/0102-6720201700010007 |
identifier_str_mv |
SOUZA, Dyego Leandro Bezerra de; AMICO, Enio Campos; ALVES, José Roberto; SALVIANO, Fellipe Alexandre Macena; JOÃO, Samir Assi; LIGUORI, Adriano de Araújo Lima. Hypervascular liver lesions in radiologically normal liver. Abcd. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), [S.L.], v. 30, n. 1, p. 21-26, mar. 2017. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/0102-6720201700010007. Disponível em: https://www.scielo.br/j/abcd/a/wR49xbttqRxXTmmBrcBjBLy/?lang=en. Acesso em: 22 set. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/54987 https://doi.org/10.1590/0102-6720201700010007 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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FapUNIFESP (SciELO) |
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FapUNIFESP (SciELO) |
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