Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells

Detalhes bibliográficos
Autor(a) principal: Santos, Everaldo Silvino dos
Data de Publicação: 2012
Outros Autores: Assis, Cristiane Fernandes de, Melo-Silveira, Raniere Fagundes, Oliveira, Ruth Medeiros de, Costa, Leandro Silva, Rocha, Hugo Alexandre de Oliveira, Macedo, Gorete Ribeiro de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/32582
Resumo: Chitooligosaccharides exhibit biological activities, including antitumor, antimicrobial and antioxidant. In this study we used a mixture of chitooligosaccharides produced by enzymatic hydrolysis in two tumor cell lines and assessed the cell proliferation and cytotoxicity of these compounds. The proliferation of HeLa cells was inhibited around by 60%
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spelling Santos, Everaldo Silvino dosAssis, Cristiane Fernandes deMelo-Silveira, Raniere FagundesOliveira, Ruth Medeiros deCosta, Leandro SilvaRocha, Hugo Alexandre de OliveiraMacedo, Gorete Ribeiro de2021-05-27T20:50:42Z2021-05-27T20:50:42Z2012SANTOS, E. S.; de Oliveira, Ruth Medeiros ; Melo-Silveira, Raniere Fagundes ; Costa, Leandro Silva ; Rocha, H. A. O. ; Macedo, Gorete Ribeiro . Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells. Journal of Bioprocessing & Biotechniques, v. 02, p. 1-3, 2012. Disponível em: https://www.hilarispublisher.com/search-results.php?keyword=Cytotoxicity+of+Chitosan+Oligomers+Produced+by. Acesso em: 13 abr 2021. DOI: 10.4172/2155-9821.1000114.2155-9821https://repositorio.ufrn.br/handle/123456789/3258210.4172/2155-9821.1000114Hilaris PublisherAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessChitooligosaccharidesHepG2 cellsHeLa cellsCytotoxicityCytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChitooligosaccharides exhibit biological activities, including antitumor, antimicrobial and antioxidant. In this study we used a mixture of chitooligosaccharides produced by enzymatic hydrolysis in two tumor cell lines and assessed the cell proliferation and cytotoxicity of these compounds. The proliferation of HeLa cells was inhibited around by 60%engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALCytotoxicityChitosanOligomers_Santos_2012.pdfCytotoxicityChitosanOligomers_Santos_2012.pdfapplication/pdf1079787https://repositorio.ufrn.br/bitstream/123456789/32582/1/CytotoxicityChitosanOligomers_Santos_2012.pdfabade319e8578a4c84667c22754dd2b3MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufrn.br/bitstream/123456789/32582/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/32582/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/325822021-05-27 17:50:42.781oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-05-27T20:50:42Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
title Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
spellingShingle Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
Santos, Everaldo Silvino dos
Chitooligosaccharides
HepG2 cells
HeLa cells
Cytotoxicity
title_short Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
title_full Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
title_fullStr Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
title_full_unstemmed Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
title_sort Cytotoxicity of chitosan oligomers produced by crude enzyme extract from the fungus metarhizium anisopliae in hepg2 and hela cells
author Santos, Everaldo Silvino dos
author_facet Santos, Everaldo Silvino dos
Assis, Cristiane Fernandes de
Melo-Silveira, Raniere Fagundes
Oliveira, Ruth Medeiros de
Costa, Leandro Silva
Rocha, Hugo Alexandre de Oliveira
Macedo, Gorete Ribeiro de
author_role author
author2 Assis, Cristiane Fernandes de
Melo-Silveira, Raniere Fagundes
Oliveira, Ruth Medeiros de
Costa, Leandro Silva
Rocha, Hugo Alexandre de Oliveira
Macedo, Gorete Ribeiro de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Everaldo Silvino dos
Assis, Cristiane Fernandes de
Melo-Silveira, Raniere Fagundes
Oliveira, Ruth Medeiros de
Costa, Leandro Silva
Rocha, Hugo Alexandre de Oliveira
Macedo, Gorete Ribeiro de
dc.subject.por.fl_str_mv Chitooligosaccharides
HepG2 cells
HeLa cells
Cytotoxicity
topic Chitooligosaccharides
HepG2 cells
HeLa cells
Cytotoxicity
description Chitooligosaccharides exhibit biological activities, including antitumor, antimicrobial and antioxidant. In this study we used a mixture of chitooligosaccharides produced by enzymatic hydrolysis in two tumor cell lines and assessed the cell proliferation and cytotoxicity of these compounds. The proliferation of HeLa cells was inhibited around by 60%
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2021-05-27T20:50:42Z
dc.date.available.fl_str_mv 2021-05-27T20:50:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, E. S.; de Oliveira, Ruth Medeiros ; Melo-Silveira, Raniere Fagundes ; Costa, Leandro Silva ; Rocha, H. A. O. ; Macedo, Gorete Ribeiro . Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells. Journal of Bioprocessing & Biotechniques, v. 02, p. 1-3, 2012. Disponível em: https://www.hilarispublisher.com/search-results.php?keyword=Cytotoxicity+of+Chitosan+Oligomers+Produced+by. Acesso em: 13 abr 2021. DOI: 10.4172/2155-9821.1000114.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/32582
dc.identifier.issn.none.fl_str_mv 2155-9821
dc.identifier.doi.none.fl_str_mv 10.4172/2155-9821.1000114
identifier_str_mv SANTOS, E. S.; de Oliveira, Ruth Medeiros ; Melo-Silveira, Raniere Fagundes ; Costa, Leandro Silva ; Rocha, H. A. O. ; Macedo, Gorete Ribeiro . Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells. Journal of Bioprocessing & Biotechniques, v. 02, p. 1-3, 2012. Disponível em: https://www.hilarispublisher.com/search-results.php?keyword=Cytotoxicity+of+Chitosan+Oligomers+Produced+by. Acesso em: 13 abr 2021. DOI: 10.4172/2155-9821.1000114.
2155-9821
10.4172/2155-9821.1000114
url https://repositorio.ufrn.br/handle/123456789/32582
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hilaris Publisher
publisher.none.fl_str_mv Hilaris Publisher
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
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