Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua.
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/17143 |
Resumo: | Several studies are carried out with aim to establish parameters to determine biologic behavior of oral squamous cell carcinoma, in order this neoplasm presents high rates of morbidity and mortality. The purpose of present research was to performe a clinic, morphologic and immunohistochemical analysis by the expression of galectins 1, 3, 4 and 7 in 65 cases of tongue squamous cell carcinoma, correlating this expression with clinics (outcome of the disease, metastasis and clinical staging) and morphologic parameters (malignancy histologic gradation system). The clinical and morphologic parameters analysed and expression of galectins 1, 3, 4 and 7 were submitted to statistical analysis (Qui2 test), observing that can be utilized as indicators of the biological behavior of the tongue squamous cell carcinoma. The galectin 1 was expressed in 87,7% of cases studied and it exhibit statistically significant correlation with metastasis (p=0,033) and clinical staging (p=0,016), it is located mostly in the citoplasm of the stomal cells. The immunoexpression of galectin 3 in 87,7% of cases was correlated with the presence of metastasis (p=0,033) and malignancy histological gradation system (p=0,031), observed, mostly of cases, in tongue squamous cell carcinoma of malignancy high grading. The galectin 4 showed no statistical significance to any of the parameters evaluated. The expression of galectin 7 in 73,8% of cases showed statistically significant correlation with the malignancy histologic grading (p=0,005), which is marking exclusively found in neoplastic epithelial cells, in the mostly of cases, it is found in cytoplasm and membrane (50%). The expressive immunopositivy of the galectins 1, 3 and 7, observed in this research, leads us to suggest a broad participation of these proteins in oral carcinogenesis, and its possible use as markers of biological behavior and tumor progression in cases of squamous cell carcinoma of the tongue |
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Alves, Pollianna Munizhttp://lattes.cnpq.br/4860117599607892http://lattes.cnpq.br/3265824235655776Godoy, Gustavo Pinahttp://lattes.cnpq.br/5655149996985928Figueiredo, Cláudia Roberta Leite Vieira dehttp://lattes.cnpq.br/9812014935249748Souza, Lélia Batista dehttp://lattes.cnpq.br/6671914892609743Medeiros, Ana Miryam Costa dehttp://lattes.cnpq.br/8375651517819318Queiroz, Lélia Maria Guedes2014-12-17T15:32:28Z2009-06-032014-12-17T15:32:28Z2009-03-06ALVES, Pollianna Muniz. Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua.. 2009. 132 f. Tese (Doutorado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2009.https://repositorio.ufrn.br/jspui/handle/123456789/17143Several studies are carried out with aim to establish parameters to determine biologic behavior of oral squamous cell carcinoma, in order this neoplasm presents high rates of morbidity and mortality. The purpose of present research was to performe a clinic, morphologic and immunohistochemical analysis by the expression of galectins 1, 3, 4 and 7 in 65 cases of tongue squamous cell carcinoma, correlating this expression with clinics (outcome of the disease, metastasis and clinical staging) and morphologic parameters (malignancy histologic gradation system). The clinical and morphologic parameters analysed and expression of galectins 1, 3, 4 and 7 were submitted to statistical analysis (Qui2 test), observing that can be utilized as indicators of the biological behavior of the tongue squamous cell carcinoma. The galectin 1 was expressed in 87,7% of cases studied and it exhibit statistically significant correlation with metastasis (p=0,033) and clinical staging (p=0,016), it is located mostly in the citoplasm of the stomal cells. The immunoexpression of galectin 3 in 87,7% of cases was correlated with the presence of metastasis (p=0,033) and malignancy histological gradation system (p=0,031), observed, mostly of cases, in tongue squamous cell carcinoma of malignancy high grading. The galectin 4 showed no statistical significance to any of the parameters evaluated. The expression of galectin 7 in 73,8% of cases showed statistically significant correlation with the malignancy histologic grading (p=0,005), which is marking exclusively found in neoplastic epithelial cells, in the mostly of cases, it is found in cytoplasm and membrane (50%). The expressive immunopositivy of the galectins 1, 3 and 7, observed in this research, leads us to suggest a broad participation of these proteins in oral carcinogenesis, and its possible use as markers of biological behavior and tumor progression in cases of squamous cell carcinoma of the tongueDiversos estudos são desenvolvidos com o intuito de se estabelecer parâmetros para determinar o comportamento biológico do carcinoma epidermóide oral, tendo em vista que esta neoplasia apresenta altas taxas de morbidade e mortalidade. O objetivo do presente trabalho foi realizar uma análise clínica, morfológica e imuno-histoquímica através da expressão das galectinas 1, 3, 4 e 7 em 65 casos de carcinoma epidermóide de língua, correlacionando essa expressão à parâmetros clínicos (desfecho da doença, metástase, estadiamento clínico) e morfológicos (sistema de gradação histológica de malignidade). Os parâmetros clínicos e morfológicos analisados e a expressão das galectinas 1, 3, 4 e 7 foram submetidos a análise estatística (teste do Qui 2), observando-se que os mesmos podem ser utilizados como indicadores do comportamento biológico do carcinoma epidermóide de língua. A galectina 1 foi expressa em 87,7% dos casos, apresentando correlação estatisticamente significativa com a metástase (p=0,033) e o estadiamento clínico (p=0,016), localizando-se principalmente no citoplasma das células estromais. A imunomarcação da galectina 3, em 87,7% dos casos, correlacionou-se com a presença de metástases (p=0,033) e a gradação histológica de malignidade (p=0,031), sendo encontrada, na maioria dos casos, em carcinoma epidermóide de língua de alto grau de malignidade. A galectina 4 não exibiu significância estatística com nenhum dos parâmetros avaliados. A marcação da galectina 7, em 73,8% dos casos, exibiu correlação estatisticamente significativa com a gradação histológica de malignidade (p=0,005), sendo esta marcação exclusivamente encontrada nas células neoplásicas, e na maioria dos casos, encontrada no citoplasma e membrana (50%). A expressiva imunomarcação das galectinas 1, 3 e 7, verificada em nossa pesquisa, nos leva a sugerir uma ampla participação dessas proteínas na carcinogênese oral, bem como a sua possível utilização como marcadores do comportamento biológico e da progressão tumoral em carcinoma epidermóide de línguaCoordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal do Rio Grande do NortePrograma de Pós-Graduação em Patologia OralUFRNBROdontologiaNeoplasias bucaisCarcinoma epidermóideGalectinasImuno-histoquímicaMouth neoplasmsSquamous cell carcinomaGalectinsImmunohistochemistryCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAAvaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALPollianaMA.pdfapplication/pdf3849977https://repositorio.ufrn.br/bitstream/123456789/17143/1/PollianaMA.pdf1bd9caa4d33368bb137c3e70ddabe0dfMD51TEXTPollianaMA.pdf.txtPollianaMA.pdf.txtExtracted texttext/plain184618https://repositorio.ufrn.br/bitstream/123456789/17143/6/PollianaMA.pdf.txt2f7f334a3272ac70044fd3d8debde3eeMD56THUMBNAILPollianaMA.pdf.jpgPollianaMA.pdf.jpgIM Thumbnailimage/jpeg3299https://repositorio.ufrn.br/bitstream/123456789/17143/7/PollianaMA.pdf.jpg6d7bf10aa2d707283dceb7f6e06cd2a8MD57123456789/171432017-11-04 13:58:18.215oai:https://repositorio.ufrn.br:123456789/17143Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2017-11-04T16:58:18Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.por.fl_str_mv |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
title |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
spellingShingle |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. Alves, Pollianna Muniz Neoplasias bucais Carcinoma epidermóide Galectinas Imuno-histoquímica Mouth neoplasms Squamous cell carcinoma Galectins Immunohistochemistry CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
title_full |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
title_fullStr |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
title_full_unstemmed |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
title_sort |
Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua. |
author |
Alves, Pollianna Muniz |
author_facet |
Alves, Pollianna Muniz |
author_role |
author |
dc.contributor.authorID.por.fl_str_mv |
|
dc.contributor.authorLattes.por.fl_str_mv |
http://lattes.cnpq.br/4860117599607892 |
dc.contributor.advisorID.por.fl_str_mv |
|
dc.contributor.advisorLattes.por.fl_str_mv |
http://lattes.cnpq.br/3265824235655776 |
dc.contributor.referees1.pt_BR.fl_str_mv |
Godoy, Gustavo Pina |
dc.contributor.referees1ID.por.fl_str_mv |
|
dc.contributor.referees1Lattes.por.fl_str_mv |
http://lattes.cnpq.br/5655149996985928 |
dc.contributor.referees2.pt_BR.fl_str_mv |
Figueiredo, Cláudia Roberta Leite Vieira de |
dc.contributor.referees2ID.por.fl_str_mv |
|
dc.contributor.referees2Lattes.por.fl_str_mv |
http://lattes.cnpq.br/9812014935249748 |
dc.contributor.referees3.pt_BR.fl_str_mv |
Souza, Lélia Batista de |
dc.contributor.referees3Lattes.por.fl_str_mv |
http://lattes.cnpq.br/6671914892609743 |
dc.contributor.referees4.pt_BR.fl_str_mv |
Medeiros, Ana Miryam Costa de |
dc.contributor.referees4ID.por.fl_str_mv |
|
dc.contributor.referees4Lattes.por.fl_str_mv |
http://lattes.cnpq.br/8375651517819318 |
dc.contributor.author.fl_str_mv |
Alves, Pollianna Muniz |
dc.contributor.advisor1.fl_str_mv |
Queiroz, Lélia Maria Guedes |
contributor_str_mv |
Queiroz, Lélia Maria Guedes |
dc.subject.por.fl_str_mv |
Neoplasias bucais Carcinoma epidermóide Galectinas Imuno-histoquímica |
topic |
Neoplasias bucais Carcinoma epidermóide Galectinas Imuno-histoquímica Mouth neoplasms Squamous cell carcinoma Galectins Immunohistochemistry CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Mouth neoplasms Squamous cell carcinoma Galectins Immunohistochemistry |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Several studies are carried out with aim to establish parameters to determine biologic behavior of oral squamous cell carcinoma, in order this neoplasm presents high rates of morbidity and mortality. The purpose of present research was to performe a clinic, morphologic and immunohistochemical analysis by the expression of galectins 1, 3, 4 and 7 in 65 cases of tongue squamous cell carcinoma, correlating this expression with clinics (outcome of the disease, metastasis and clinical staging) and morphologic parameters (malignancy histologic gradation system). The clinical and morphologic parameters analysed and expression of galectins 1, 3, 4 and 7 were submitted to statistical analysis (Qui2 test), observing that can be utilized as indicators of the biological behavior of the tongue squamous cell carcinoma. The galectin 1 was expressed in 87,7% of cases studied and it exhibit statistically significant correlation with metastasis (p=0,033) and clinical staging (p=0,016), it is located mostly in the citoplasm of the stomal cells. The immunoexpression of galectin 3 in 87,7% of cases was correlated with the presence of metastasis (p=0,033) and malignancy histological gradation system (p=0,031), observed, mostly of cases, in tongue squamous cell carcinoma of malignancy high grading. The galectin 4 showed no statistical significance to any of the parameters evaluated. The expression of galectin 7 in 73,8% of cases showed statistically significant correlation with the malignancy histologic grading (p=0,005), which is marking exclusively found in neoplastic epithelial cells, in the mostly of cases, it is found in cytoplasm and membrane (50%). The expressive immunopositivy of the galectins 1, 3 and 7, observed in this research, leads us to suggest a broad participation of these proteins in oral carcinogenesis, and its possible use as markers of biological behavior and tumor progression in cases of squamous cell carcinoma of the tongue |
publishDate |
2009 |
dc.date.available.fl_str_mv |
2009-06-03 2014-12-17T15:32:28Z |
dc.date.issued.fl_str_mv |
2009-03-06 |
dc.date.accessioned.fl_str_mv |
2014-12-17T15:32:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALVES, Pollianna Muniz. Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua.. 2009. 132 f. Tese (Doutorado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2009. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/17143 |
identifier_str_mv |
ALVES, Pollianna Muniz. Avaliação imuno-histoquímica das galectinas-1, -3, -4 e -7 em carcinoma epidermóide de língua.. 2009. 132 f. Tese (Doutorado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2009. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/17143 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal do Rio Grande do Norte |
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Programa de Pós-Graduação em Patologia Oral |
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UFRN |
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BR |
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Odontologia |
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Universidade Federal do Rio Grande do Norte |
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