NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects

Detalhes bibliográficos
Autor(a) principal: Sequerra, Eduardo Bouth
Data de Publicação: 2018
Outros Autores: Goyal, Raman, Castro, Patricio A., Levin, Jacqueline B., Borodinsky, Laura N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/25139
Resumo: 2018-10-30
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spelling Sequerra, Eduardo BouthGoyal, RamanCastro, Patricio A.Levin, Jacqueline B.Borodinsky, Laura N.2018-05-09T13:26:46Z2018-04-30SEQUERRA, E. B. et al. NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects. J Neurosci., pii: 2634-17, abr./2018. DOI: 10.1523/JNEUROSCI.2634-17.2018https://repositorio.ufrn.br/jspui/handle/123456789/2513910.1523/JNEUROSCI.2634-17.2018engNeural Tube DefectN-methyl-D-aspartateDesenvolvimentoPlasticidade neuralNMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-10-30Failure of neural tube closure leads to neural tube defects (NTDs), which can have serious neurological consequences or be lethal. Use of antiepileptic drugs (AEDs) during pregnancy increases the incidence of NTDs in offspring by unknown mechanisms. Here we show that during Xenopus laevis neural tube formation, neural plate cells exhibit spontaneous calcium dynamics that are partially mediated by glutamate signaling. We demonstrate that N-methyl-D-aspartate (NMDA) receptors are important for the formation of the neural tube and loss of their function induces an increase in neural plate cell proliferation and impairs neural cell migration, which result in NTDs. We present evidence that the AED valproic acid perturbs glutamate signaling, leading to NTDs that are rescued with varied efficacy by preventing DNA synthesis, activating NMDA receptors, or recruiting the NMDA receptor target ERK1/2. These findings may prompt mechanistic identification of AEDs that do not interfere with neural tube formation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALEduardoSequerra_ICe_2018_ NMDA receptor.pdfEduardoSequerra_ICe_2018_ NMDA receptor.pdfEduardoSequerra_ICe_2018_ NMDA receptorapplication/pdf9279597https://repositorio.ufrn.br/bitstream/123456789/25139/1/EduardoSequerra_ICe_2018_%20NMDA%20receptor.pdf1e54fac127d7f060295cb1c57802b9c8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25139/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTEduardoSequerra_ICe_2018_ NMDA receptor.pdf.txtEduardoSequerra_ICe_2018_ NMDA receptor.pdf.txtExtracted texttext/plain66235https://repositorio.ufrn.br/bitstream/123456789/25139/3/EduardoSequerra_ICe_2018_%20NMDA%20receptor.pdf.txt3f6ae8ee30c14bde2797d3facc5cab07MD53THUMBNAILEduardoSequerra_ICe_2018_ NMDA receptor.pdf.jpgEduardoSequerra_ICe_2018_ NMDA receptor.pdf.jpgIM Thumbnailimage/jpeg9322https://repositorio.ufrn.br/bitstream/123456789/25139/4/EduardoSequerra_ICe_2018_%20NMDA%20receptor.pdf.jpgd15801c242e0e12d9d6f5f660f38de91MD54123456789/251392024-03-19 01:05:59.249oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-19T04:05:59Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
title NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
spellingShingle NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
Sequerra, Eduardo Bouth
Neural Tube Defect
N-methyl-D-aspartate
Desenvolvimento
Plasticidade neural
title_short NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
title_full NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
title_fullStr NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
title_full_unstemmed NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
title_sort NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects
author Sequerra, Eduardo Bouth
author_facet Sequerra, Eduardo Bouth
Goyal, Raman
Castro, Patricio A.
Levin, Jacqueline B.
Borodinsky, Laura N.
author_role author
author2 Goyal, Raman
Castro, Patricio A.
Levin, Jacqueline B.
Borodinsky, Laura N.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sequerra, Eduardo Bouth
Goyal, Raman
Castro, Patricio A.
Levin, Jacqueline B.
Borodinsky, Laura N.
dc.subject.por.fl_str_mv Neural Tube Defect
N-methyl-D-aspartate
Desenvolvimento
Plasticidade neural
topic Neural Tube Defect
N-methyl-D-aspartate
Desenvolvimento
Plasticidade neural
description 2018-10-30
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-05-09T13:26:46Z
dc.date.issued.fl_str_mv 2018-04-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SEQUERRA, E. B. et al. NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects. J Neurosci., pii: 2634-17, abr./2018. DOI: 10.1523/JNEUROSCI.2634-17.2018
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/25139
dc.identifier.doi.none.fl_str_mv 10.1523/JNEUROSCI.2634-17.2018
identifier_str_mv SEQUERRA, E. B. et al. NMDA receptor signaling is important for neural tube formation and for preventing antiepileptic drug-induced neural tube defects. J Neurosci., pii: 2634-17, abr./2018. DOI: 10.1523/JNEUROSCI.2634-17.2018
10.1523/JNEUROSCI.2634-17.2018
url https://repositorio.ufrn.br/jspui/handle/123456789/25139
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
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reponame_str Repositório Institucional da UFRN
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