Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®

• Autor(a) principal: Albuquerque, Ingrid da Silva
• Data de Publicação: 2020
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/35821
• topic: Ferulic Acid; Amorphous Solid Dispersions; Soluplus®

Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the aim of the present study was to develop an ASD containing FA using different obtaining methods. Soluplus® was selected by solubility study with FA, from this were obtained ASD with ferulic acid by physical mixture (PM), kneading (KND) and evaporation rotary (ER). The solid dispersions were quantified by UV/Vis spectrophotometry and characterized physical-chemically by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential exploratory calorimetry (DSC). The results demonstrated the formation of amorphous solid dispersion through the techniques used, and KND and ER showed better results with significant reductions in the intensities of crystalline reflections by the XRD, as well as in the intensity of the bands in the FTIR and the absence of the characteristic fusion peak of AF in the DSC of the samples. Thus, it can be concluded that solid dispersions with ferulic acid were obtained, which will be investigated later for dissolution and antioxidant activity in vitro.