Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/35821 |
Resumo: | Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the aim of the present study was to develop an ASD containing FA using different obtaining methods. Soluplus® was selected by solubility study with FA, from this were obtained ASD with ferulic acid by physical mixture (PM), kneading (KND) and evaporation rotary (ER). The solid dispersions were quantified by UV/Vis spectrophotometry and characterized physical-chemically by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential exploratory calorimetry (DSC). The results demonstrated the formation of amorphous solid dispersion through the techniques used, and KND and ER showed better results with significant reductions in the intensities of crystalline reflections by the XRD, as well as in the intensity of the bands in the FTIR and the absence of the characteristic fusion peak of AF in the DSC of the samples. Thus, it can be concluded that solid dispersions with ferulic acid were obtained, which will be investigated later for dissolution and antioxidant activity in vitro. |
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Albuquerque, Ingrid da SilvaFernanda Ílary Costa DuarteOliveira , VerônicaGomes, Ana Paulade Lima, Ádley2020-07-09T14:17:25Z2021-09-20T17:52:28Z2020-07-09T14:17:25Z2021-09-20T17:52:28Z2020-06-182016082163ALBUQUERQUE, Ingrid da Silva. Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and Soluplus®. 2020. 39f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020.https://repositorio.ufrn.br/handle/123456789/35821Universidade Federal do Rio Grande do NorteUFRNBrasilFarmáciaFerulic AcidAmorphous Solid DispersionsSoluplus®Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus®info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisFerulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the aim of the present study was to develop an ASD containing FA using different obtaining methods. Soluplus® was selected by solubility study with FA, from this were obtained ASD with ferulic acid by physical mixture (PM), kneading (KND) and evaporation rotary (ER). The solid dispersions were quantified by UV/Vis spectrophotometry and characterized physical-chemically by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential exploratory calorimetry (DSC). The results demonstrated the formation of amorphous solid dispersion through the techniques used, and KND and ER showed better results with significant reductions in the intensities of crystalline reflections by the XRD, as well as in the intensity of the bands in the FTIR and the absence of the characteristic fusion peak of AF in the DSC of the samples. Thus, it can be concluded that solid dispersions with ferulic acid were obtained, which will be investigated later for dissolution and antioxidant activity in vitro.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALSelectionofsuitablepolymer_Albuquerque_2020Texto Completoapplication/octet-stream961017https://repositorio.ufrn.br/bitstream/123456789/35821/1/Selectionofsuitablepolymer_Albuquerque_2020a895f286f2a6b1f35b51aafdc18afb9eMD51LICENSElicense.txttext/plain714https://repositorio.ufrn.br/bitstream/123456789/35821/2/license.txt7278bab9c5c886812fa7d225dc807888MD52TEXTSelectionofsuitablepolymer_Albuquerque_2020.txtExtracted texttext/plain54897https://repositorio.ufrn.br/bitstream/123456789/35821/3/Selectionofsuitablepolymer_Albuquerque_2020.txt41f67c4b5b57b1b42fce4739c3deb0f6MD53123456789/358212021-09-20 14:52:28.27oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-09-20T17:52:28Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
title |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
spellingShingle |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® Albuquerque, Ingrid da Silva Ferulic Acid Amorphous Solid Dispersions Soluplus® |
title_short |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
title_full |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
title_fullStr |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
title_full_unstemmed |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
title_sort |
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and soluplus® |
author |
Albuquerque, Ingrid da Silva |
author_facet |
Albuquerque, Ingrid da Silva |
author_role |
author |
dc.contributor.referees1.none.fl_str_mv |
Oliveira , Verônica |
dc.contributor.referees2.none.fl_str_mv |
Gomes, Ana Paula |
dc.contributor.author.fl_str_mv |
Albuquerque, Ingrid da Silva |
dc.contributor.advisor-co1.fl_str_mv |
Fernanda Ílary Costa Duarte |
dc.contributor.advisor1.fl_str_mv |
de Lima, Ádley |
contributor_str_mv |
Fernanda Ílary Costa Duarte de Lima, Ádley |
dc.subject.por.fl_str_mv |
Ferulic Acid Amorphous Solid Dispersions Soluplus® |
topic |
Ferulic Acid Amorphous Solid Dispersions Soluplus® |
description |
Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the aim of the present study was to develop an ASD containing FA using different obtaining methods. Soluplus® was selected by solubility study with FA, from this were obtained ASD with ferulic acid by physical mixture (PM), kneading (KND) and evaporation rotary (ER). The solid dispersions were quantified by UV/Vis spectrophotometry and characterized physical-chemically by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential exploratory calorimetry (DSC). The results demonstrated the formation of amorphous solid dispersion through the techniques used, and KND and ER showed better results with significant reductions in the intensities of crystalline reflections by the XRD, as well as in the intensity of the bands in the FTIR and the absence of the characteristic fusion peak of AF in the DSC of the samples. Thus, it can be concluded that solid dispersions with ferulic acid were obtained, which will be investigated later for dissolution and antioxidant activity in vitro. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-07-09T14:17:25Z 2021-09-20T17:52:28Z |
dc.date.available.fl_str_mv |
2020-07-09T14:17:25Z 2021-09-20T17:52:28Z |
dc.date.issued.fl_str_mv |
2020-06-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.pt_BR.fl_str_mv |
2016082163 |
dc.identifier.citation.fl_str_mv |
ALBUQUERQUE, Ingrid da Silva. Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and Soluplus®. 2020. 39f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/35821 |
identifier_str_mv |
2016082163 ALBUQUERQUE, Ingrid da Silva. Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and Soluplus®. 2020. 39f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020. |
url |
https://repositorio.ufrn.br/handle/123456789/35821 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
dc.publisher.initials.fl_str_mv |
UFRN |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Farmácia |
publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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