BDNF controls object recognition memory reconsolidation

Detalhes bibliográficos
Autor(a) principal: Radiske, Andressa
Data de Publicação: 2017
Outros Autores: Rossato, Janine I., Gonzalez, Maria Carolina, Köhler, Cristiano A., Bevilaqua, Lia Rejane Müller, Cammarota, Martín Pablo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/23352
Resumo: Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1 impairs updating of the reactivated recognition memory trace.
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spelling Radiske, AndressaRossato, Janine I.Gonzalez, Maria CarolinaKöhler, Cristiano A.Bevilaqua, Lia Rejane MüllerCammarota, Martín Pablo2017-06-01T19:37:13Z2017-06-01T19:37:13Z20171074-7427https://repositorio.ufrn.br/jspui/handle/123456789/23352engAnisomycina-amanitinMuscimolNoveltyRetrievalBDNF controls object recognition memory reconsolidationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleReconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1 impairs updating of the reactivated recognition memory trace.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALBDNF controls object recognition memory reconsolidation.pdfBDNF controls object recognition memory reconsolidation.pdfArtigo completoapplication/pdf1341721https://repositorio.ufrn.br/bitstream/123456789/23352/1/BDNF%20controls%20object%20recognition%20memory%20reconsolidation.pdf273f8212dfa66593929ba22b5bcd0e6fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23352/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTBDNF controls object recognition memory reconsolidation.pdf.txtBDNF controls object recognition memory reconsolidation.pdf.txtExtracted texttext/plain36071https://repositorio.ufrn.br/bitstream/123456789/23352/5/BDNF%20controls%20object%20recognition%20memory%20reconsolidation.pdf.txtcbf65df93bd0023658d69c826518cc2eMD55THUMBNAILBDNF controls object recognition memory reconsolidation.pdf.jpgBDNF controls object recognition memory reconsolidation.pdf.jpgIM Thumbnailimage/jpeg9203https://repositorio.ufrn.br/bitstream/123456789/23352/6/BDNF%20controls%20object%20recognition%20memory%20reconsolidation.pdf.jpgef158ae7f44cb21410d5be7d1150011cMD56123456789/233522021-07-09 18:02:33.428oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T21:02:33Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv BDNF controls object recognition memory reconsolidation
title BDNF controls object recognition memory reconsolidation
spellingShingle BDNF controls object recognition memory reconsolidation
Radiske, Andressa
Anisomycin
a-amanitin
Muscimol
Novelty
Retrieval
title_short BDNF controls object recognition memory reconsolidation
title_full BDNF controls object recognition memory reconsolidation
title_fullStr BDNF controls object recognition memory reconsolidation
title_full_unstemmed BDNF controls object recognition memory reconsolidation
title_sort BDNF controls object recognition memory reconsolidation
author Radiske, Andressa
author_facet Radiske, Andressa
Rossato, Janine I.
Gonzalez, Maria Carolina
Köhler, Cristiano A.
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
author_role author
author2 Rossato, Janine I.
Gonzalez, Maria Carolina
Köhler, Cristiano A.
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Radiske, Andressa
Rossato, Janine I.
Gonzalez, Maria Carolina
Köhler, Cristiano A.
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
dc.subject.por.fl_str_mv Anisomycin
a-amanitin
Muscimol
Novelty
Retrieval
topic Anisomycin
a-amanitin
Muscimol
Novelty
Retrieval
description Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1 impairs updating of the reactivated recognition memory trace.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-06-01T19:37:13Z
dc.date.available.fl_str_mv 2017-06-01T19:37:13Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/23352
dc.identifier.issn.none.fl_str_mv 1074-7427
identifier_str_mv 1074-7427
url https://repositorio.ufrn.br/jspui/handle/123456789/23352
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
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