Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid

Detalhes bibliográficos
Autor(a) principal: Brandão, Gustavo Henrique Azevedo
Data de Publicação: 2017
Outros Autores: Rigo, Graziela Vargas, Roque, A. A., Souza, A. C. D., Scopel, Marina, Nascimento, Cláudio Augusto Oller do, Tasca, Tiana, Courtial, Camila Gambini Pereira, Giordani, Raquel Brandt
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/32508
Resumo: The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxic
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spelling Brandão, Gustavo Henrique AzevedoRigo, Graziela VargasRoque, A. A.Souza, A. C. D.Scopel, MarinaNascimento, Cláudio Augusto Oller doTasca, TianaCourtial, Camila Gambini PereiraGiordani, Raquel Brandt2021-05-12T18:14:08Z2021-05-12T18:14:08Z2017-11BRANDÃO, G.H.A.; RIGO, G.; ROQUE, A.A.; SOUZA, A.C.D.; SCOPEL, M.; NASCIMENTO, C.A.O.; TASCA, T.; PEREIRA, C.G.; GIORDANI, R.B. . Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid. JOURNAL OF SUPERCRITICAL FLUIDS, v. 129, p. 28-35, 2017. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0896844616305630?via%3Dihub. Acesso em: 05 abr. 2021. https://doi.org/10.1016/j.supflu.2016.12.0120896-8446https://repositorio.ufrn.br/handle/123456789/3250810.1016/j.supflu.2016.12.012ElsevierAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessMelocactus zehntneriAlkaloidsSupercritical fluidsTrichomonas vaginalisHMVIIaExtraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxicengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALExtractionBioactiveAlkaloids_Pereira_2017.pdfExtractionBioactiveAlkaloids_Pereira_2017.pdfArtigoapplication/pdf881562https://repositorio.ufrn.br/bitstream/123456789/32508/1/ExtractionBioactiveAlkaloids_Pereira_2017.pdffbe19c7f6cca4deede53aa28740cafb2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/32508/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/32508/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52123456789/325082021-11-19 13:52:32.405oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-19T16:52:32Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
spellingShingle Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
Brandão, Gustavo Henrique Azevedo
Melocactus zehntneri
Alkaloids
Supercritical fluids
Trichomonas vaginalis
HMVIIa
title_short Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_full Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_fullStr Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_full_unstemmed Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
title_sort Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
author Brandão, Gustavo Henrique Azevedo
author_facet Brandão, Gustavo Henrique Azevedo
Rigo, Graziela Vargas
Roque, A. A.
Souza, A. C. D.
Scopel, Marina
Nascimento, Cláudio Augusto Oller do
Tasca, Tiana
Courtial, Camila Gambini Pereira
Giordani, Raquel Brandt
author_role author
author2 Rigo, Graziela Vargas
Roque, A. A.
Souza, A. C. D.
Scopel, Marina
Nascimento, Cláudio Augusto Oller do
Tasca, Tiana
Courtial, Camila Gambini Pereira
Giordani, Raquel Brandt
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brandão, Gustavo Henrique Azevedo
Rigo, Graziela Vargas
Roque, A. A.
Souza, A. C. D.
Scopel, Marina
Nascimento, Cláudio Augusto Oller do
Tasca, Tiana
Courtial, Camila Gambini Pereira
Giordani, Raquel Brandt
dc.subject.por.fl_str_mv Melocactus zehntneri
Alkaloids
Supercritical fluids
Trichomonas vaginalis
HMVIIa
topic Melocactus zehntneri
Alkaloids
Supercritical fluids
Trichomonas vaginalis
HMVIIa
description The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxic
publishDate 2017
dc.date.issued.fl_str_mv 2017-11
dc.date.accessioned.fl_str_mv 2021-05-12T18:14:08Z
dc.date.available.fl_str_mv 2021-05-12T18:14:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRANDÃO, G.H.A.; RIGO, G.; ROQUE, A.A.; SOUZA, A.C.D.; SCOPEL, M.; NASCIMENTO, C.A.O.; TASCA, T.; PEREIRA, C.G.; GIORDANI, R.B. . Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid. JOURNAL OF SUPERCRITICAL FLUIDS, v. 129, p. 28-35, 2017. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0896844616305630?via%3Dihub. Acesso em: 05 abr. 2021. https://doi.org/10.1016/j.supflu.2016.12.012
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/32508
dc.identifier.issn.none.fl_str_mv 0896-8446
dc.identifier.doi.none.fl_str_mv 10.1016/j.supflu.2016.12.012
identifier_str_mv BRANDÃO, G.H.A.; RIGO, G.; ROQUE, A.A.; SOUZA, A.C.D.; SCOPEL, M.; NASCIMENTO, C.A.O.; TASCA, T.; PEREIRA, C.G.; GIORDANI, R.B. . Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid. JOURNAL OF SUPERCRITICAL FLUIDS, v. 129, p. 28-35, 2017. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0896844616305630?via%3Dihub. Acesso em: 05 abr. 2021. https://doi.org/10.1016/j.supflu.2016.12.012
0896-8446
10.1016/j.supflu.2016.12.012
url https://repositorio.ufrn.br/handle/123456789/32508
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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