Characterizing speed cells in the rat hippocampus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/26422 |
Resumo: | Spatial navigation relies on visual landmarks as well as on self-motion information. In familiar environments, both place and grid cells maintain their firing fields in darkness, suggesting that they continuously receive information about locomotion speed required for path integration. Consistently, "speed cells" have been previously identified in the hippocampal formation and characterized in detail in the medial entorhinal cortex. Here we investigated speed-correlated firing in the hippocampus. We show that CA1 has speed cells that are stable across contexts, position in space, and time. Moreover, their speed-correlated firing occurs within theta cycles, independently of theta frequency. Interestingly, a physiological classification of cell types reveals that all CA1 speed cells are inhibitory. In fact, while speed modulates pyramidal cell activity, only the firing rate of interneurons can accurately predict locomotion speed on a sub-second timescale. These findings shed light on network models of navigation. |
id |
UFRN_7fa8530d2aacc02aecd5c2a9856b40d7 |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/26422 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Góis, Zé Henrique T. D.Tort, Adriano Bretanha Lopes2019-01-07T16:28:30Z2019-01-07T16:28:30Z2018-11-13GÓIS, Z. H. T. D.; TORT, A. B. L. Characterizing Speed Cells in the Rat Hippocampus. [S. l.], Cell Reports, n. 25, v. 7, p. 1872–1884. doi: 10.1016/j.celrep.2018.10.054https://repositorio.ufrn.br/jspui/handle/123456789/2642210.1016/j.celrep.2018.10.054.engCA1hippocampusneuronal codingpath integrationplace cellsrate codingspatial navigationspeed cellsthetaCharacterizing speed cells in the rat hippocampusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSpatial navigation relies on visual landmarks as well as on self-motion information. In familiar environments, both place and grid cells maintain their firing fields in darkness, suggesting that they continuously receive information about locomotion speed required for path integration. Consistently, "speed cells" have been previously identified in the hippocampal formation and characterized in detail in the medial entorhinal cortex. Here we investigated speed-correlated firing in the hippocampus. We show that CA1 has speed cells that are stable across contexts, position in space, and time. Moreover, their speed-correlated firing occurs within theta cycles, independently of theta frequency. Interestingly, a physiological classification of cell types reveals that all CA1 speed cells are inhibitory. In fact, while speed modulates pyramidal cell activity, only the firing rate of interneurons can accurately predict locomotion speed on a sub-second timescale. These findings shed light on network models of navigation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTAdrianoTort_ICe_2018_Characterizing speed cells.pdf.txtAdrianoTort_ICe_2018_Characterizing speed cells.pdf.txtExtracted texttext/plain88618https://repositorio.ufrn.br/bitstream/123456789/26422/3/AdrianoTort_ICe_2018_Characterizing%20speed%20cells.pdf.txt8610dfe339a113082c97e2f4aa0af34bMD53THUMBNAILAdrianoTort_ICe_2018_Characterizing speed cells.pdf.jpgAdrianoTort_ICe_2018_Characterizing speed cells.pdf.jpgIM Thumbnailimage/jpeg9905https://repositorio.ufrn.br/bitstream/123456789/26422/4/AdrianoTort_ICe_2018_Characterizing%20speed%20cells.pdf.jpg594f436b99f9ce66d0417b3586b33648MD54ORIGINALAdrianoTort_ICe_2018_Characterizing speed cells.pdfAdrianoTort_ICe_2018_Characterizing speed cells.pdfAdrianoTort_ICe_2018_Characterizing speed cellsapplication/pdf3643147https://repositorio.ufrn.br/bitstream/123456789/26422/1/AdrianoTort_ICe_2018_Characterizing%20speed%20cells.pdfa93151408de29283ed585f24b582b7b8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/26422/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/264222021-07-08 10:52:48.352oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T13:52:48Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Characterizing speed cells in the rat hippocampus |
title |
Characterizing speed cells in the rat hippocampus |
spellingShingle |
Characterizing speed cells in the rat hippocampus Góis, Zé Henrique T. D. CA1 hippocampus neuronal coding path integration place cells rate coding spatial navigation speed cells theta |
title_short |
Characterizing speed cells in the rat hippocampus |
title_full |
Characterizing speed cells in the rat hippocampus |
title_fullStr |
Characterizing speed cells in the rat hippocampus |
title_full_unstemmed |
Characterizing speed cells in the rat hippocampus |
title_sort |
Characterizing speed cells in the rat hippocampus |
author |
Góis, Zé Henrique T. D. |
author_facet |
Góis, Zé Henrique T. D. Tort, Adriano Bretanha Lopes |
author_role |
author |
author2 |
Tort, Adriano Bretanha Lopes |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Góis, Zé Henrique T. D. Tort, Adriano Bretanha Lopes |
dc.subject.por.fl_str_mv |
CA1 hippocampus neuronal coding path integration place cells rate coding spatial navigation speed cells theta |
topic |
CA1 hippocampus neuronal coding path integration place cells rate coding spatial navigation speed cells theta |
description |
Spatial navigation relies on visual landmarks as well as on self-motion information. In familiar environments, both place and grid cells maintain their firing fields in darkness, suggesting that they continuously receive information about locomotion speed required for path integration. Consistently, "speed cells" have been previously identified in the hippocampal formation and characterized in detail in the medial entorhinal cortex. Here we investigated speed-correlated firing in the hippocampus. We show that CA1 has speed cells that are stable across contexts, position in space, and time. Moreover, their speed-correlated firing occurs within theta cycles, independently of theta frequency. Interestingly, a physiological classification of cell types reveals that all CA1 speed cells are inhibitory. In fact, while speed modulates pyramidal cell activity, only the firing rate of interneurons can accurately predict locomotion speed on a sub-second timescale. These findings shed light on network models of navigation. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-11-13 |
dc.date.accessioned.fl_str_mv |
2019-01-07T16:28:30Z |
dc.date.available.fl_str_mv |
2019-01-07T16:28:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GÓIS, Z. H. T. D.; TORT, A. B. L. Characterizing Speed Cells in the Rat Hippocampus. [S. l.], Cell Reports, n. 25, v. 7, p. 1872–1884. doi: 10.1016/j.celrep.2018.10.054 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/26422 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.celrep.2018.10.054. |
identifier_str_mv |
GÓIS, Z. H. T. D.; TORT, A. B. L. Characterizing Speed Cells in the Rat Hippocampus. [S. l.], Cell Reports, n. 25, v. 7, p. 1872–1884. doi: 10.1016/j.celrep.2018.10.054 10.1016/j.celrep.2018.10.054. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/26422 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/26422/3/AdrianoTort_ICe_2018_Characterizing%20speed%20cells.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/26422/4/AdrianoTort_ICe_2018_Characterizing%20speed%20cells.pdf.jpg https://repositorio.ufrn.br/bitstream/123456789/26422/1/AdrianoTort_ICe_2018_Characterizing%20speed%20cells.pdf https://repositorio.ufrn.br/bitstream/123456789/26422/2/license.txt |
bitstream.checksum.fl_str_mv |
8610dfe339a113082c97e2f4aa0af34b 594f436b99f9ce66d0417b3586b33648 a93151408de29283ed585f24b582b7b8 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117884175974400 |