Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/57481 http://dx.doi.org/10.1590/0037-8682-0419-2016 |
Resumo: | Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. Methods: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department. Reverse transcription polymerase chain reaction (RT-PCR) assays for dengue serotypes were carried out on plasma samples obtained from patients with suspected dengue. The data were analysed using descriptive statistics.Results: According to clinical features, dengue fever [n = 39,083 (70.2%)] and dengue without warning signs [n = 15,365 (27.7%)] were the most common classifications of dengue. On RT-PCR, DENV 1 was the most commonly identified serotype (80.5%) in all years studied. Co-circulation of all four DENV serotypes was observed in 2013 and 2014. Furthermore, we observed an increase in dengue notifications in 2015, possibly due to the rise of Zika and chikungunya. Conclusions: Our findings support the hypothesis that co-circulation of the four DENV serotypes may be a reason for the increased prevalence of severe forms of dengue in the years studied. This study may contribute to directing research, health policy, and financial resources toward reducing poorly controlled epidemic diseases |
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Maciel, Bruna Leal LimaGuerra-Gomes, Isabel CristinaPeixoto, Rephany FonsecaOliveira, Camila AlvesSarmento, Maria Izabel FerreiraPachá, Anna Stella CysneirosAraújo, Josélio Maria GalvãoAmaral, Ian Porto GurgelKeesen, Tatjana Souza Lima2024-02-02T12:39:53Z2024-02-02T12:39:53Z2017-02GUERRA-GOMES, Isabel Cristina; GOIS, Bruna Macêdo; PEIXOTO, Rephany Fonseca; OLIVEIRA, Camila Alves; MACIEL, Bruna Leal Lima; SARMENTO, Maria Izabel Ferreira; PACHÁ, Anna Stella Cysneiros; ARAÚJO, Josélio Maria Galvão; AMARAL, Ian Porto Gurgel; KEESEN, Tatjana Souza Lima. Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil. Revista da Sociedade Brasileira de Medicina Tropical, [S.l.], v. 50, n. 1, p. 19-26, fev. 2017. DOI: 10.1590/0037-8682-0419-2016. Disponível em: https://www.scielo.br/j/rsbmt/a/757QyYDCyb8F8xkLFBc3cNn/?lang=en#. Acesso em: 31 jan. 2024.https://repositorio.ufrn.br/handle/123456789/57481http://dx.doi.org/10.1590/0037-8682-0419-2016Revista da Sociedade Brasileira de Medicina TropicalAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessDENV serotypesMolecular epidemiologyArbovirusesMolecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDespite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. Methods: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department. Reverse transcription polymerase chain reaction (RT-PCR) assays for dengue serotypes were carried out on plasma samples obtained from patients with suspected dengue. The data were analysed using descriptive statistics.Results: According to clinical features, dengue fever [n = 39,083 (70.2%)] and dengue without warning signs [n = 15,365 (27.7%)] were the most common classifications of dengue. On RT-PCR, DENV 1 was the most commonly identified serotype (80.5%) in all years studied. Co-circulation of all four DENV serotypes was observed in 2013 and 2014. Furthermore, we observed an increase in dengue notifications in 2015, possibly due to the rise of Zika and chikungunya. Conclusions: Our findings support the hypothesis that co-circulation of the four DENV serotypes may be a reason for the increased prevalence of severe forms of dengue in the years studied. This study may contribute to directing research, health policy, and financial resources toward reducing poorly controlled epidemic diseasesengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMolecularClinical_GuerraGomes_2017.pdfMolecularClinical_GuerraGomes_2017.pdfapplication/pdf999898https://repositorio.ufrn.br/bitstream/123456789/57481/1/MolecularClinical_GuerraGomes_2017.pdfd9900db29e2b2383ec96d4efb4d5e262MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/57481/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/57481/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/574812024-02-02 09:39:53.858oai:https://repositorio.ufrn.br:123456789/57481Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKCkJ5IHNpZ25pbmcgYW5kIGRlbGl2ZXJpbmcgdGhpcyBsaWNlbnNlLCBNci4gKGF1dGhvciBvciBjb3B5cmlnaHQgaG9sZGVyKToKCgphKSBHcmFudHMgdGhlIFVuaXZlcnNpZGFkZSBGZWRlcmFsIFJpbyBHcmFuZGUgZG8gTm9ydGUgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgb2YKcmVwcm9kdWNlLCBjb252ZXJ0IChhcyBkZWZpbmVkIGJlbG93KSwgY29tbXVuaWNhdGUgYW5kIC8gb3IKZGlzdHJpYnV0ZSB0aGUgZGVsaXZlcmVkIGRvY3VtZW50IChpbmNsdWRpbmcgYWJzdHJhY3QgLyBhYnN0cmFjdCkgaW4KZGlnaXRhbCBvciBwcmludGVkIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bS4KCmIpIERlY2xhcmVzIHRoYXQgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBpdHMgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQKeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gRGVjbGFyZXMKdGhhdCB0aGUgZGVsaXZlcnkgb2YgdGhlIGRvY3VtZW50IGRvZXMgbm90IGluZnJpbmdlLCBhcyBmYXIgYXMgaXQgaXMKdGhlIHJpZ2h0cyBvZiBhbnkgb3RoZXIgcGVyc29uIG9yIGVudGl0eS4KCmMpIElmIHRoZSBkb2N1bWVudCBkZWxpdmVyZWQgY29udGFpbnMgbWF0ZXJpYWwgd2hpY2ggZG9lcyBub3QKcmlnaHRzLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBvYnRhaW5lZCBhdXRob3JpemF0aW9uIGZyb20gdGhlIGhvbGRlciBvZiB0aGUKY29weXJpZ2h0IHRvIGdyYW50IHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCB0aGlzIG1hdGVyaWFsIHdob3NlIHJpZ2h0cyBhcmUgb2YKdGhpcmQgcGFydGllcyBpcyBjbGVhcmx5IGlkZW50aWZpZWQgYW5kIHJlY29nbml6ZWQgaW4gdGhlIHRleHQgb3IKY29udGVudCBvZiB0aGUgZG9jdW1lbnQgZGVsaXZlcmVkLgoKSWYgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBiYXNlZCBvbiBmdW5kZWQgb3Igc3VwcG9ydGVkIHdvcmsKYnkgYW5vdGhlciBpbnN0aXR1dGlvbiBvdGhlciB0aGFuIHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBmdWxmaWxsZWQgYW55IG9ibGlnYXRpb25zIHJlcXVpcmVkIGJ5IHRoZSByZXNwZWN0aXZlIGFncmVlbWVudCBvciBhZ3JlZW1lbnQuCgpUaGUgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgaXRzIG5hbWUgKHMpIGFzIHRoZSBhdXRob3IgKHMpIG9yIGhvbGRlciAocykgb2YgdGhlIGRvY3VtZW50J3MgcmlnaHRzCmRlbGl2ZXJlZCwgYW5kIHdpbGwgbm90IG1ha2UgYW55IGNoYW5nZXMsIG90aGVyIHRoYW4gdGhvc2UgcGVybWl0dGVkIGJ5CnRoaXMgbGljZW5zZQo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-02-02T12:39:53Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
title |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
spellingShingle |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil Maciel, Bruna Leal Lima DENV serotypes Molecular epidemiology Arboviruses |
title_short |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
title_full |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
title_fullStr |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
title_full_unstemmed |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
title_sort |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, northeast Brazil |
author |
Maciel, Bruna Leal Lima |
author_facet |
Maciel, Bruna Leal Lima Guerra-Gomes, Isabel Cristina Peixoto, Rephany Fonseca Oliveira, Camila Alves Sarmento, Maria Izabel Ferreira Pachá, Anna Stella Cysneiros Araújo, Josélio Maria Galvão Amaral, Ian Porto Gurgel Keesen, Tatjana Souza Lima |
author_role |
author |
author2 |
Guerra-Gomes, Isabel Cristina Peixoto, Rephany Fonseca Oliveira, Camila Alves Sarmento, Maria Izabel Ferreira Pachá, Anna Stella Cysneiros Araújo, Josélio Maria Galvão Amaral, Ian Porto Gurgel Keesen, Tatjana Souza Lima |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maciel, Bruna Leal Lima Guerra-Gomes, Isabel Cristina Peixoto, Rephany Fonseca Oliveira, Camila Alves Sarmento, Maria Izabel Ferreira Pachá, Anna Stella Cysneiros Araújo, Josélio Maria Galvão Amaral, Ian Porto Gurgel Keesen, Tatjana Souza Lima |
dc.subject.por.fl_str_mv |
DENV serotypes Molecular epidemiology Arboviruses |
topic |
DENV serotypes Molecular epidemiology Arboviruses |
description |
Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. Methods: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department. Reverse transcription polymerase chain reaction (RT-PCR) assays for dengue serotypes were carried out on plasma samples obtained from patients with suspected dengue. The data were analysed using descriptive statistics.Results: According to clinical features, dengue fever [n = 39,083 (70.2%)] and dengue without warning signs [n = 15,365 (27.7%)] were the most common classifications of dengue. On RT-PCR, DENV 1 was the most commonly identified serotype (80.5%) in all years studied. Co-circulation of all four DENV serotypes was observed in 2013 and 2014. Furthermore, we observed an increase in dengue notifications in 2015, possibly due to the rise of Zika and chikungunya. Conclusions: Our findings support the hypothesis that co-circulation of the four DENV serotypes may be a reason for the increased prevalence of severe forms of dengue in the years studied. This study may contribute to directing research, health policy, and financial resources toward reducing poorly controlled epidemic diseases |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-02 |
dc.date.accessioned.fl_str_mv |
2024-02-02T12:39:53Z |
dc.date.available.fl_str_mv |
2024-02-02T12:39:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUERRA-GOMES, Isabel Cristina; GOIS, Bruna Macêdo; PEIXOTO, Rephany Fonseca; OLIVEIRA, Camila Alves; MACIEL, Bruna Leal Lima; SARMENTO, Maria Izabel Ferreira; PACHÁ, Anna Stella Cysneiros; ARAÚJO, Josélio Maria Galvão; AMARAL, Ian Porto Gurgel; KEESEN, Tatjana Souza Lima. Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil. Revista da Sociedade Brasileira de Medicina Tropical, [S.l.], v. 50, n. 1, p. 19-26, fev. 2017. DOI: 10.1590/0037-8682-0419-2016. Disponível em: https://www.scielo.br/j/rsbmt/a/757QyYDCyb8F8xkLFBc3cNn/?lang=en#. Acesso em: 31 jan. 2024. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/57481 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0419-2016 |
identifier_str_mv |
GUERRA-GOMES, Isabel Cristina; GOIS, Bruna Macêdo; PEIXOTO, Rephany Fonseca; OLIVEIRA, Camila Alves; MACIEL, Bruna Leal Lima; SARMENTO, Maria Izabel Ferreira; PACHÁ, Anna Stella Cysneiros; ARAÚJO, Josélio Maria Galvão; AMARAL, Ian Porto Gurgel; KEESEN, Tatjana Souza Lima. Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil. Revista da Sociedade Brasileira de Medicina Tropical, [S.l.], v. 50, n. 1, p. 19-26, fev. 2017. DOI: 10.1590/0037-8682-0419-2016. Disponível em: https://www.scielo.br/j/rsbmt/a/757QyYDCyb8F8xkLFBc3cNn/?lang=en#. Acesso em: 31 jan. 2024. |
url |
https://repositorio.ufrn.br/handle/123456789/57481 http://dx.doi.org/10.1590/0037-8682-0419-2016 |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Revista da Sociedade Brasileira de Medicina Tropical |
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Revista da Sociedade Brasileira de Medicina Tropical |
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