Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/21801 |
Resumo: | Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front. |
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Silveira, Ericka Janine Dantas daMiguel, Marcia Cristina da CostaLima, Kenio Costa deFreitas, Roseana de AlmeidaMorais, Maria de Lourdes Silva Arruda deQueiroz, Lelia Maria Guedes2017-01-30T13:04:05Z2017-01-30T13:04:05Z2010SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010.https://repositorio.ufrn.br/jspui/handle/123456789/21801engSquamous cell carcinomaTongueLower lipImmunohistochemistryLocal immune responseAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lipinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/21801/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52TEXTAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.txtAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.txtExtracted texttext/plain27336https://repositorio.ufrn.br/bitstream/123456789/21801/5/Analysis%20of%20local%20immunity%20in%20squamous%20cell%20carcinoma%20of%20the%20tongue%20and%20lower%20lip_2010.pdf.txtb26d5830aa2756a1e9e9f1344513a122MD55THUMBNAILAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.jpgAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.jpgIM Thumbnailimage/jpeg9142https://repositorio.ufrn.br/bitstream/123456789/21801/6/Analysis%20of%20local%20immunity%20in%20squamous%20cell%20carcinoma%20of%20the%20tongue%20and%20lower%20lip_2010.pdf.jpgdceb6870a298ea7c94f5fa0884dd7cb1MD56123456789/218012023-02-03 19:21:01.014oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-02-03T22:21:01Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
title |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
spellingShingle |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip Silveira, Ericka Janine Dantas da Squamous cell carcinoma Tongue Lower lip Immunohistochemistry Local immune response |
title_short |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
title_full |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
title_fullStr |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
title_full_unstemmed |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
title_sort |
Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip |
author |
Silveira, Ericka Janine Dantas da |
author_facet |
Silveira, Ericka Janine Dantas da Miguel, Marcia Cristina da Costa Lima, Kenio Costa de Freitas, Roseana de Almeida Morais, Maria de Lourdes Silva Arruda de Queiroz, Lelia Maria Guedes |
author_role |
author |
author2 |
Miguel, Marcia Cristina da Costa Lima, Kenio Costa de Freitas, Roseana de Almeida Morais, Maria de Lourdes Silva Arruda de Queiroz, Lelia Maria Guedes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silveira, Ericka Janine Dantas da Miguel, Marcia Cristina da Costa Lima, Kenio Costa de Freitas, Roseana de Almeida Morais, Maria de Lourdes Silva Arruda de Queiroz, Lelia Maria Guedes |
dc.subject.por.fl_str_mv |
Squamous cell carcinoma Tongue Lower lip Immunohistochemistry Local immune response |
topic |
Squamous cell carcinoma Tongue Lower lip Immunohistochemistry Local immune response |
description |
Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2017-01-30T13:04:05Z |
dc.date.available.fl_str_mv |
2017-01-30T13:04:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/21801 |
identifier_str_mv |
SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/21801 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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