Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip

Detalhes bibliográficos
Autor(a) principal: Silveira, Ericka Janine Dantas da
Data de Publicação: 2010
Outros Autores: Miguel, Marcia Cristina da Costa, Lima, Kenio Costa de, Freitas, Roseana de Almeida, Morais, Maria de Lourdes Silva Arruda de, Queiroz, Lelia Maria Guedes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/21801
Resumo: Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.
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spelling Silveira, Ericka Janine Dantas daMiguel, Marcia Cristina da CostaLima, Kenio Costa deFreitas, Roseana de AlmeidaMorais, Maria de Lourdes Silva Arruda deQueiroz, Lelia Maria Guedes2017-01-30T13:04:05Z2017-01-30T13:04:05Z2010SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010.https://repositorio.ufrn.br/jspui/handle/123456789/21801engSquamous cell carcinomaTongueLower lipImmunohistochemistryLocal immune responseAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lipinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/21801/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52TEXTAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.txtAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.txtExtracted texttext/plain27336https://repositorio.ufrn.br/bitstream/123456789/21801/5/Analysis%20of%20local%20immunity%20in%20squamous%20cell%20carcinoma%20of%20the%20tongue%20and%20lower%20lip_2010.pdf.txtb26d5830aa2756a1e9e9f1344513a122MD55THUMBNAILAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.jpgAnalysis of local immunity in squamous cell carcinoma of the tongue and lower lip_2010.pdf.jpgIM Thumbnailimage/jpeg9142https://repositorio.ufrn.br/bitstream/123456789/21801/6/Analysis%20of%20local%20immunity%20in%20squamous%20cell%20carcinoma%20of%20the%20tongue%20and%20lower%20lip_2010.pdf.jpgdceb6870a298ea7c94f5fa0884dd7cb1MD56123456789/218012023-02-03 19:21:01.014oai:https://repositorio.ufrn.br:123456789/21801TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkZSBhdXRvcik6CgphKSBDb25jZWRlIMOgIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRvIFJpbyBHcmFuZGUgZG8gTm9ydGUgbyBkaXJlaXRvIG7Do28tZXhjbHVzaXZvIGRlCnJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhYmFpeG8pLCBjb211bmljYXIgZS9vdQpkaXN0cmlidWlyIG8gZG9jdW1lbnRvIGVudHJlZ3VlIChpbmNsdWluZG8gbyByZXN1bW8vYWJzdHJhY3QpIGVtCmZvcm1hdG8gZGlnaXRhbCBvdSBpbXByZXNzbyBlIGVtIHF1YWxxdWVyIG1laW8uCgpiKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDDqSBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlCmRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgb3MgZGlyZWl0b3MgY29udGlkb3MgbmVzdGEgbGljZW7Dp2EuIERlY2xhcmEKdGFtYsOpbSBxdWUgYSBlbnRyZWdhIGRvIGRvY3VtZW50byBuw6NvIGluZnJpbmdlLCB0YW50byBxdWFudG8gbGhlIMOpCnBvc3PDrXZlbCBzYWJlciwgb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKYykgU2UgbyBkb2N1bWVudG8gZW50cmVndWUgY29udMOpbSBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zCmRpcmVpdG9zIGRlIGF1dG9yLCBkZWNsYXJhIHF1ZSBvYnRldmUgYXV0b3JpemHDp8OjbyBkbyBkZXRlbnRvciBkb3MKZGlyZWl0b3MgZGUgYXV0b3IgcGFyYSBjb25jZWRlciDDoCBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW7Dp2EsIGUgcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZQp0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdQpjb250ZcO6ZG8gZG8gZG9jdW1lbnRvIGVudHJlZ3VlLgoKU2UgbyBkb2N1bWVudG8gZW50cmVndWUgw6kgYmFzZWFkbyBlbSB0cmFiYWxobyBmaW5hbmNpYWRvIG91IGFwb2lhZG8KcG9yIG91dHJhIGluc3RpdHVpw6fDo28gcXVlIG7Do28gYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJhIHF1ZSBjdW1wcml1IHF1YWlzcXVlciBvYnJpZ2HDp8O1ZXMgZXhpZ2lkYXMgcGVsbyByZXNwZWN0aXZvIGNvbnRyYXRvIG91IGFjb3Jkby4KCkEgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSAgaWRlbnRpZmljYXLDoSBjbGFyYW1lbnRlIG8ocykgc2V1IChzKSBub21lKHMpIGNvbW8gbyAocykgYXV0b3IgKGVzKSBvdSBkZXRlbnRvciAoZXMpIGRvcyBkaXJlaXRvcyBkbyBkb2N1bWVudG8KZW50cmVndWUsIGUgbsOjbyBmYXLDoSBxdWFscXVlciBhbHRlcmHDp8OjbywgcGFyYSBhbMOpbSBkYXMgcGVybWl0aWRhcyBwb3IKZXN0YSBsaWNlbsOnYS4KRepositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-02-03T22:21:01Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
spellingShingle Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
Silveira, Ericka Janine Dantas da
Squamous cell carcinoma
Tongue
Lower lip
Immunohistochemistry
Local immune response
title_short Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_full Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_fullStr Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_full_unstemmed Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
title_sort Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip
author Silveira, Ericka Janine Dantas da
author_facet Silveira, Ericka Janine Dantas da
Miguel, Marcia Cristina da Costa
Lima, Kenio Costa de
Freitas, Roseana de Almeida
Morais, Maria de Lourdes Silva Arruda de
Queiroz, Lelia Maria Guedes
author_role author
author2 Miguel, Marcia Cristina da Costa
Lima, Kenio Costa de
Freitas, Roseana de Almeida
Morais, Maria de Lourdes Silva Arruda de
Queiroz, Lelia Maria Guedes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silveira, Ericka Janine Dantas da
Miguel, Marcia Cristina da Costa
Lima, Kenio Costa de
Freitas, Roseana de Almeida
Morais, Maria de Lourdes Silva Arruda de
Queiroz, Lelia Maria Guedes
dc.subject.por.fl_str_mv Squamous cell carcinoma
Tongue
Lower lip
Immunohistochemistry
Local immune response
topic Squamous cell carcinoma
Tongue
Lower lip
Immunohistochemistry
Local immune response
description Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-01-30T13:04:05Z
dc.date.available.fl_str_mv 2017-01-30T13:04:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/21801
identifier_str_mv SILVEIRA, Éricka Janine Dantas et al. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Experimental and Molecular Pathology, v. 88, n. 1, p. 171-175, 2010.
url https://repositorio.ufrn.br/jspui/handle/123456789/21801
dc.language.iso.fl_str_mv eng
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