Leucemia mielóide crônica: uma revisão de literatura

• Autor(a) principal: Peixoto, Paloma Pinheiro de Aquino
• Data de Publicação: 2017
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/43167
• topic: Leucemia mielóide crônica; Chronic Myelogenous Leukemia; Cromossomo Philadelphia; Philadelphia chromosome; Fatores de risco; Risk factors

This work aimed to perform a bibliographic survey on chronic myeloid leukemia (CML) in scientifc databases in order to obtain a better knowledge about this disease. CML is a myeloproliferative disease, a type of non-hereditary cancer that develops in the bone marrow. It is characterized by the presence of the Philadelphia (Ph) chromosome, originated by a translocation in chromosomes 9 and 22. The Ph chromosome is responsible for the production of an enzyme, BCR-ABL, which is related to the pathogenesis of the disease. CML is more common in adults in the 40-year age group. The clinical course of the disease is divided into three phases: a chronic phase, which is the initial period of the disease, and may last for months or years. An accelerated phase, in which the disease progresses more rapidly and an intensification of the symptoms occurs, and finally a blast phase, the worst period of the disease, when many complications may occur and lack of response in the treatment. Regarding diagnostic exams we can mention the hemogram, showing hyperleukocytosis, the appearance of immature cells and increase of eosinophils and basophils, other exams such as myelogram, cytogenetic and molecular analyzes are also essential for the diagnosis of CML. As for the treatment, there are several tyrosine kinase inhibitor drugs, that are well tolerated by patients in most cases providing a good life expectancy. There is also bone marrow transplantation as a therapeutic form of the disease. Thus, although chronic myelogenous leukemia is a serious and worrying disease, the technological advance in human medicine has been increasing day by day and bringing new therapeutic measures with greater possibility of cure and more hope for patients.