Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25140 |
Resumo: | Background: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. Purpose: To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). Materials and methods: TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session. Results: We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI β-values and increased MEP amplitude post-MT, in the affected hemisphere. Conclusion: Our study suggests that a single MT intervention in stroke survivors is related to increased MEP of the affected limb, and a more constrained activity of the affected M1, as if activity had become more constrained and limited to the affected hemisphere. |
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Novaes, Morgana M.Palhano-Fontes, FernandaPeres, AndreMazzetto-Betti, KelleyPelicioni, MaristelaAndrade, Kátia C.Santos, Antonio Carlos dosPontes-Neto, OctavioAraújo, Dráulio Barros de2018-05-09T13:27:03Z2018-05-09T13:27:03Z2018-03-20NOVAES, M. M. et al. Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke. Int J Neurosci., v. 20, p. 1-9, mar./2018. DOI:10.1080/00207454.2018.1447571https://repositorio.ufrn.br/jspui/handle/123456789/2514010.1080/00207454.2018.1447571engMirror therapyischemic strokestroke rehabilitationtranscranial magnetic stimulationfunctional magnetic resonance imagingNeurofunctional changes after a single mirror therapy intervention in chronic ischemic strokeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. Purpose: To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). Materials and methods: TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session. Results: We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI β-values and increased MEP amplitude post-MT, in the affected hemisphere. Conclusion: Our study suggests that a single MT intervention in stroke survivors is related to increased MEP of the affected limb, and a more constrained activity of the affected M1, as if activity had become more constrained and limited to the affected hemisphere.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALDraulioAraujo_ICe_2018_Neurofunctional changes.pdfDraulioAraujo_ICe_2018_Neurofunctional changes.pdfDraulioAraujo_ICe_2018_Neurofunctional changesapplication/pdf1990969https://repositorio.ufrn.br/bitstream/123456789/25140/1/DraulioAraujo_ICe_2018_Neurofunctional%20changes.pdfd90198eabda2109951131c2bb9768711MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25140/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTDraulioAraujo_ICe_2018_Neurofunctional changes.pdf.txtDraulioAraujo_ICe_2018_Neurofunctional changes.pdf.txtExtracted texttext/plain41910https://repositorio.ufrn.br/bitstream/123456789/25140/3/DraulioAraujo_ICe_2018_Neurofunctional%20changes.pdf.txt4156cdd2fd5b2b2f1ed58b6ca33eee96MD53THUMBNAILDraulioAraujo_ICe_2018_Neurofunctional changes.pdf.jpgDraulioAraujo_ICe_2018_Neurofunctional changes.pdf.jpgIM Thumbnailimage/jpeg5888https://repositorio.ufrn.br/bitstream/123456789/25140/4/DraulioAraujo_ICe_2018_Neurofunctional%20changes.pdf.jpga80d889d58e545cae80f9c39fd122238MD54123456789/251402021-07-08 15:30:06.876oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T18:30:06Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
title |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
spellingShingle |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke Novaes, Morgana M. Mirror therapy ischemic stroke stroke rehabilitation transcranial magnetic stimulation functional magnetic resonance imaging |
title_short |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
title_full |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
title_fullStr |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
title_full_unstemmed |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
title_sort |
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke |
author |
Novaes, Morgana M. |
author_facet |
Novaes, Morgana M. Palhano-Fontes, Fernanda Peres, Andre Mazzetto-Betti, Kelley Pelicioni, Maristela Andrade, Kátia C. Santos, Antonio Carlos dos Pontes-Neto, Octavio Araújo, Dráulio Barros de |
author_role |
author |
author2 |
Palhano-Fontes, Fernanda Peres, Andre Mazzetto-Betti, Kelley Pelicioni, Maristela Andrade, Kátia C. Santos, Antonio Carlos dos Pontes-Neto, Octavio Araújo, Dráulio Barros de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Novaes, Morgana M. Palhano-Fontes, Fernanda Peres, Andre Mazzetto-Betti, Kelley Pelicioni, Maristela Andrade, Kátia C. Santos, Antonio Carlos dos Pontes-Neto, Octavio Araújo, Dráulio Barros de |
dc.subject.por.fl_str_mv |
Mirror therapy ischemic stroke stroke rehabilitation transcranial magnetic stimulation functional magnetic resonance imaging |
topic |
Mirror therapy ischemic stroke stroke rehabilitation transcranial magnetic stimulation functional magnetic resonance imaging |
description |
Background: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. Purpose: To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). Materials and methods: TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session. Results: We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI β-values and increased MEP amplitude post-MT, in the affected hemisphere. Conclusion: Our study suggests that a single MT intervention in stroke survivors is related to increased MEP of the affected limb, and a more constrained activity of the affected M1, as if activity had become more constrained and limited to the affected hemisphere. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-05-09T13:27:03Z |
dc.date.available.fl_str_mv |
2018-05-09T13:27:03Z |
dc.date.issued.fl_str_mv |
2018-03-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NOVAES, M. M. et al. Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke. Int J Neurosci., v. 20, p. 1-9, mar./2018. DOI:10.1080/00207454.2018.1447571 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/25140 |
dc.identifier.doi.none.fl_str_mv |
10.1080/00207454.2018.1447571 |
identifier_str_mv |
NOVAES, M. M. et al. Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke. Int J Neurosci., v. 20, p. 1-9, mar./2018. DOI:10.1080/00207454.2018.1447571 10.1080/00207454.2018.1447571 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/25140 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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