Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/21800 |
Resumo: | This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate fibronectin expression in the stroma. Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma. |
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Medeiros, Ana Miryam Costa deNonaka, Cassiano Francisco WeegeGalvão, Hebel CavalcantiSouza, Lelia Batista deFreitas, Roseana de Almeida2017-01-30T13:00:36Z2017-01-30T13:00:36Z2010MEDEIROS, Ana Miryam Costa et al. Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors. European Archives of Oto-Rhino-Laryngology, v. 267, n. 2, p. 303-310, 2010.https://repositorio.ufrn.br/jspui/handle/123456789/21800engAmeloblastomaAdenomatoid odontogenic tumorFibronectinTenascinCollagenExpression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThis study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate fibronectin expression in the stroma. Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/21800/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52ORIGINALExpressionExtracellularMatrix_Medeiros_2010.pdfExpressionExtracellularMatrix_Medeiros_2010.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/19466441application/pdf562724https://repositorio.ufrn.br/bitstream/123456789/21800/1/ExpressionExtracellularMatrix_Medeiros_2010.pdfaa153c7f18e8c0c3535b21fcebfdc814MD51TEXTExpression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors_2010.pdf.txtExpression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors_2010.pdf.txtExtracted texttext/plain32333https://repositorio.ufrn.br/bitstream/123456789/21800/5/Expression%20of%20extracellular%20matrix%20proteins%20in%20ameloblastomas%20and%20adenomatoid%20odontogenic%20tumors_2010.pdf.txt51810026d26653532cc24287f2717650MD55THUMBNAILExpression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors_2010.pdf.jpgExpression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors_2010.pdf.jpgIM Thumbnailimage/jpeg8433https://repositorio.ufrn.br/bitstream/123456789/21800/6/Expression%20of%20extracellular%20matrix%20proteins%20in%20ameloblastomas%20and%20adenomatoid%20odontogenic%20tumors_2010.pdf.jpga0573292825ce9a2edcc7817018ad2d9MD56123456789/218002021-12-20 15:45:57.761oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-20T18:45:57Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
title |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
spellingShingle |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors Medeiros, Ana Miryam Costa de Ameloblastoma Adenomatoid odontogenic tumor Fibronectin Tenascin Collagen |
title_short |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
title_full |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
title_fullStr |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
title_full_unstemmed |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
title_sort |
Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors |
author |
Medeiros, Ana Miryam Costa de |
author_facet |
Medeiros, Ana Miryam Costa de Nonaka, Cassiano Francisco Weege Galvão, Hebel Cavalcanti Souza, Lelia Batista de Freitas, Roseana de Almeida |
author_role |
author |
author2 |
Nonaka, Cassiano Francisco Weege Galvão, Hebel Cavalcanti Souza, Lelia Batista de Freitas, Roseana de Almeida |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Medeiros, Ana Miryam Costa de Nonaka, Cassiano Francisco Weege Galvão, Hebel Cavalcanti Souza, Lelia Batista de Freitas, Roseana de Almeida |
dc.subject.por.fl_str_mv |
Ameloblastoma Adenomatoid odontogenic tumor Fibronectin Tenascin Collagen |
topic |
Ameloblastoma Adenomatoid odontogenic tumor Fibronectin Tenascin Collagen |
description |
This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate fibronectin expression in the stroma. Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2017-01-30T13:00:36Z |
dc.date.available.fl_str_mv |
2017-01-30T13:00:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MEDEIROS, Ana Miryam Costa et al. Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors. European Archives of Oto-Rhino-Laryngology, v. 267, n. 2, p. 303-310, 2010. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/21800 |
identifier_str_mv |
MEDEIROS, Ana Miryam Costa et al. Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors. European Archives of Oto-Rhino-Laryngology, v. 267, n. 2, p. 303-310, 2010. |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/21800 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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