Evolução do estado nutricional de pacientes com Distrofia Muscular de Duchenne

• Autor(a) principal: Cunha, Thais
• Data de Publicação: 2018
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/40026
• topic: Distrofia Muscular de Duchenne; Composição corporal; Antropometria; CNPQ::CIENCIAS DA SAUDE

Introduction Duchenne Muscular Dystrophy is a hereditary recessive disease linked to the X chromosome, in the dystrophin gene, which is an essential protein for muscle contraction, and when deficient or absent leads to exhaustive cycles of degeneration and regeneration of muscle fiber, causing the replacement of muscle fibers by connective and adipose tissue. Objective To analyze the evolution of the nutritional status of patients with Duchenne Muscular Dystrophy. Methodology The study is observational of the prospective type. For analysis, the parameters of the Corrected Arm Muscle Area, Tricipital Cutaneous Fold, and Body Mass Index, assessed in the first and second evaluation with the nutritionist. Results During the 11.1 (4.4) month period, the 26 children and adolescents (ages 9.3 - 18.4 years) evaluated presented p = 0.553 with a variation of +0.67 (5.09) cm² for the corrected Arm Muscle Area; p <0.001 with +5.10 (5.35) mm for Tricipital Cutaneous Fold; and p = 0.007 with +2.17 (2.88) kg/m² for the Body Mass Index. Significance level was considered p <0.05. Conclusion From the results, it was possible to observe a positive variation of the Body Mass Index presented by the individuals with Duchenne Muscular Dystrophy, and could be caused by the increase of the body fat in detriment of the muscular mass, based on the information of the Tricipital Cutaneous Fold and Area Muscle of the corrected arm, respectively.