Long-term decrease in immediate early gene expression after electroconvulsive seizures
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23255 |
Resumo: | Electroconvulsive therapy (ECT) is a wellestablished psychiatric treatment for severe depression. Despite its clinical utility, post-ECT memory deficits are a common side effect. Neuronal plasticity and memory consolidation are intimately related to the expression of immediate early genes (IEG), such as Egr1, Fos and Arc. Changes in IEG activation have been postulated to underlie long-term neuronal adaptations following electroconvulsive seizures (ECS), an animal model of ECT. To test this hypothesis, we used real-time PCR to examine the effect of acute and chronic ECS (8 sessions, one every other day) on the long-term ([24 h) expression of IEG Egr1, Fos and Arc in the hippocampus, a brain region implicated both in the pathophysiology of depression as well as in memory function. We observed a transient increase in Egr1 and Fos expression immediately after ECS, followed by a long-term decrease of IEGlevels after both acute and chronic ECS.Aseparate group of animals, submitted to the same chronic ECS protocol and then subjected to open field or passive avoidance tasks, confirmed robust memory deficits 2 weeks after the last chronic ECS. The possible role of IEG downregulation on long-term learning deficits observed following ECS are discussed. |
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Calais, Julien BragaValvassori, Samira S.Resende, Wilson R.Feier, GustavoAthie, Maria Carolina PedroRibeiro, Sidarta Tollendal GomesGattaz, Wagner FaridQuevedo, JoãoOjopi, Elida Benquique2017-05-31T11:32:54Z2017-05-31T11:32:54Z2012-08-090300-9564https://repositorio.ufrn.br/jspui/handle/123456789/23255engArcEgr1Electroconvulsive seizuresFosMemoryLong-term decrease in immediate early gene expression after electroconvulsive seizuresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleElectroconvulsive therapy (ECT) is a wellestablished psychiatric treatment for severe depression. Despite its clinical utility, post-ECT memory deficits are a common side effect. Neuronal plasticity and memory consolidation are intimately related to the expression of immediate early genes (IEG), such as Egr1, Fos and Arc. Changes in IEG activation have been postulated to underlie long-term neuronal adaptations following electroconvulsive seizures (ECS), an animal model of ECT. To test this hypothesis, we used real-time PCR to examine the effect of acute and chronic ECS (8 sessions, one every other day) on the long-term ([24 h) expression of IEG Egr1, Fos and Arc in the hippocampus, a brain region implicated both in the pathophysiology of depression as well as in memory function. We observed a transient increase in Egr1 and Fos expression immediately after ECS, followed by a long-term decrease of IEGlevels after both acute and chronic ECS.Aseparate group of animals, submitted to the same chronic ECS protocol and then subjected to open field or passive avoidance tasks, confirmed robust memory deficits 2 weeks after the last chronic ECS. The possible role of IEG downregulation on long-term learning deficits observed following ECS are discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23255/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALLong-term decrease in immediate early gene expression.pdfLong-term decrease in immediate early gene expression.pdfArtigo completoapplication/pdf297265https://repositorio.ufrn.br/bitstream/123456789/23255/1/Long-term%20decrease%20in%20immediate%20early%20gene%20expression.pdfcac91354eebb81edcbe699605797fc7aMD51TEXTLong-term decrease in immediate early gene expression.pdf.txtLong-term decrease in immediate early gene expression.pdf.txtExtracted texttext/plain38352https://repositorio.ufrn.br/bitstream/123456789/23255/5/Long-term%20decrease%20in%20immediate%20early%20gene%20expression.pdf.txt853edb23e8485a309548df4a9ea1e284MD55THUMBNAILLong-term decrease in immediate early gene expression.pdf.jpgLong-term decrease in immediate early gene expression.pdf.jpgIM Thumbnailimage/jpeg8699https://repositorio.ufrn.br/bitstream/123456789/23255/6/Long-term%20decrease%20in%20immediate%20early%20gene%20expression.pdf.jpgf2ce5951488907bc8b1d14588d0311baMD56123456789/232552021-07-10 19:32:13.915oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-10T22:32:13Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
title |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
spellingShingle |
Long-term decrease in immediate early gene expression after electroconvulsive seizures Calais, Julien Braga Arc Egr1 Electroconvulsive seizures Fos Memory |
title_short |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
title_full |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
title_fullStr |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
title_full_unstemmed |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
title_sort |
Long-term decrease in immediate early gene expression after electroconvulsive seizures |
author |
Calais, Julien Braga |
author_facet |
Calais, Julien Braga Valvassori, Samira S. Resende, Wilson R. Feier, Gustavo Athie, Maria Carolina Pedro Ribeiro, Sidarta Tollendal Gomes Gattaz, Wagner Farid Quevedo, João Ojopi, Elida Benquique |
author_role |
author |
author2 |
Valvassori, Samira S. Resende, Wilson R. Feier, Gustavo Athie, Maria Carolina Pedro Ribeiro, Sidarta Tollendal Gomes Gattaz, Wagner Farid Quevedo, João Ojopi, Elida Benquique |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Calais, Julien Braga Valvassori, Samira S. Resende, Wilson R. Feier, Gustavo Athie, Maria Carolina Pedro Ribeiro, Sidarta Tollendal Gomes Gattaz, Wagner Farid Quevedo, João Ojopi, Elida Benquique |
dc.subject.por.fl_str_mv |
Arc Egr1 Electroconvulsive seizures Fos Memory |
topic |
Arc Egr1 Electroconvulsive seizures Fos Memory |
description |
Electroconvulsive therapy (ECT) is a wellestablished psychiatric treatment for severe depression. Despite its clinical utility, post-ECT memory deficits are a common side effect. Neuronal plasticity and memory consolidation are intimately related to the expression of immediate early genes (IEG), such as Egr1, Fos and Arc. Changes in IEG activation have been postulated to underlie long-term neuronal adaptations following electroconvulsive seizures (ECS), an animal model of ECT. To test this hypothesis, we used real-time PCR to examine the effect of acute and chronic ECS (8 sessions, one every other day) on the long-term ([24 h) expression of IEG Egr1, Fos and Arc in the hippocampus, a brain region implicated both in the pathophysiology of depression as well as in memory function. We observed a transient increase in Egr1 and Fos expression immediately after ECS, followed by a long-term decrease of IEGlevels after both acute and chronic ECS.Aseparate group of animals, submitted to the same chronic ECS protocol and then subjected to open field or passive avoidance tasks, confirmed robust memory deficits 2 weeks after the last chronic ECS. The possible role of IEG downregulation on long-term learning deficits observed following ECS are discussed. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-08-09 |
dc.date.accessioned.fl_str_mv |
2017-05-31T11:32:54Z |
dc.date.available.fl_str_mv |
2017-05-31T11:32:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
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https://repositorio.ufrn.br/jspui/handle/123456789/23255 |
dc.identifier.issn.none.fl_str_mv |
0300-9564 |
identifier_str_mv |
0300-9564 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23255 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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