Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFRN |
| Texto Completo: | https://repositorio.ufrn.br/jspui/handle/1/2951 |
Resumo: | AZEVEDO, George Dantas de et al. Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study. Maturitas, Amsterdam, v.47, n.3, p.195-200, 2004 |
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Azevedo, George Dantas dePrado, Maria Fernanda Massoni doFerriani, Rui AlbertoReis, Rosana Maria dosBerezowski, Aderson TadeuRibeiro, Tatiane FloresSilva, EsterMaranhão, Técia Maria de OliveiraSá, Marcos Felipe Silva de2010-09-03T16:49:32Z2010-09-03T16:49:32Z2004AZEVEDO, G. D.; PRADO, M. F. M. ; FERRIANI, R. A.; REIS, R. M.; BEREZOWSKI, A. T.; RIBEIRO, T. F.; SILVA, E.; MARAMHÃO, T. M. O.; SA. M. F. S. (2004)https://repositorio.ufrn.br/jspui/handle/1/2951AZEVEDO, George Dantas de et al. Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study. Maturitas, Amsterdam, v.47, n.3, p.195-200, 2004Objective:To monitor the effects of raloxifene therapy on the uterus of postmenopausalwomen by transvaginal ultrasonography and color flow Doppler. Methods: Twenty-five healthy postmenopausal women were enrolled in this prospective longitudinal study performed at Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto. The patients were treated with raloxifene hydrochloride (60 mg per day) for 6 months. All were submitted to transvaginal ultrasound examination with color flow Doppler (ATL-HDI 3000 equipment) before the beginning and after 1, 3 and 6 months of treatment. Resistance index (RI) and pulsatility index (PI) of the uterine arteries were determined by the Doppler method, being considered as indicators of uterine perfusion. The following variables were analyzed: endometrial thickness, uterine volume, RI, and PI. Data were analyzed statistically by repeated-measures analysis of variance. Results: Before treatment, endometrial thickness was 3.38 ± 0.73 mm, and similar values were observed after 1, 3 and 6 months of treatment (3.04 ± 0.82; 3.3 ± 0.83; and 3.37 ± 0.79, respectively) (P > 0.05). No significant differences in uterine volume were observed between the pre- and post-treatment periods. Uterine artery perfusion as indicated by RI and PI measured by Doppler also showed no significant variation, with a high impedance flow being maintained throughout treatment. Conclusions: In the group studied here, raloxifene treatment at the dose of 60 mg per day for 6 months did not induce significant changes in endometrial thickness, uterine volume or uterine artery perfusion, confirming that short-term raloxifene treatment does not affect the uterus of postmenopausal womenporMenopauseClimacterySelective estrogen receptor modulatorRaloxifeneDopplerEndometriumRaloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALRaloxifeneTherapyAffect_Azevedo_2004.pdfRaloxifeneTherapyAffect_Azevedo_2004.pdfapplication/pdf70396https://repositorio.ufrn.br/bitstream/1/2951/1/RaloxifeneTherapyAffect_Azevedo_2004.pdfdd1cabbf83e1c043535546f7fe8cf773MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/1/2951/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXT2004Art_TeciaMOM_Raloxifene.pdf.txt2004Art_TeciaMOM_Raloxifene.pdf.txtExtracted texttext/plain25115https://repositorio.ufrn.br/bitstream/1/2951/7/2004Art_TeciaMOM_Raloxifene.pdf.txta077c052e54c0c72fcd1534eb4cfbe7bMD57THUMBNAIL2004Art_TeciaMOM_Raloxifene.pdf.jpg2004Art_TeciaMOM_Raloxifene.pdf.jpgIM Thumbnailimage/jpeg3589https://repositorio.ufrn.br/bitstream/1/2951/8/2004Art_TeciaMOM_Raloxifene.pdf.jpgc7ed454d0bfa7b6ef65ed66d82354ae7MD581/29512021-11-12 15:41:18.474oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-12T18:41:18Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
| dc.title.pt_BR.fl_str_mv |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| title |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| spellingShingle |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study Azevedo, George Dantas de Menopause Climactery Selective estrogen receptor modulator Raloxifene Doppler Endometrium |
| title_short |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| title_full |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| title_fullStr |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| title_full_unstemmed |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| title_sort |
Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study |
| author |
Azevedo, George Dantas de |
| author_facet |
Azevedo, George Dantas de Prado, Maria Fernanda Massoni do Ferriani, Rui Alberto Reis, Rosana Maria dos Berezowski, Aderson Tadeu Ribeiro, Tatiane Flores Silva, Ester Maranhão, Técia Maria de Oliveira Sá, Marcos Felipe Silva de |
| author_role |
author |
| author2 |
Prado, Maria Fernanda Massoni do Ferriani, Rui Alberto Reis, Rosana Maria dos Berezowski, Aderson Tadeu Ribeiro, Tatiane Flores Silva, Ester Maranhão, Técia Maria de Oliveira Sá, Marcos Felipe Silva de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Azevedo, George Dantas de Prado, Maria Fernanda Massoni do Ferriani, Rui Alberto Reis, Rosana Maria dos Berezowski, Aderson Tadeu Ribeiro, Tatiane Flores Silva, Ester Maranhão, Técia Maria de Oliveira Sá, Marcos Felipe Silva de |
| dc.subject.por.fl_str_mv |
Menopause Climactery Selective estrogen receptor modulator Raloxifene Doppler Endometrium |
| topic |
Menopause Climactery Selective estrogen receptor modulator Raloxifene Doppler Endometrium |
| description |
AZEVEDO, George Dantas de et al. Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study. Maturitas, Amsterdam, v.47, n.3, p.195-200, 2004 |
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2004 |
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2004 |
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2010-09-03T16:49:32Z |
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2010-09-03T16:49:32Z |
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info:eu-repo/semantics/publishedVersion |
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AZEVEDO, G. D.; PRADO, M. F. M. ; FERRIANI, R. A.; REIS, R. M.; BEREZOWSKI, A. T.; RIBEIRO, T. F.; SILVA, E.; MARAMHÃO, T. M. O.; SA. M. F. S. (2004) |
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AZEVEDO, G. D.; PRADO, M. F. M. ; FERRIANI, R. A.; REIS, R. M.; BEREZOWSKI, A. T.; RIBEIRO, T. F.; SILVA, E.; MARAMHÃO, T. M. O.; SA. M. F. S. (2004) |
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