LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology

• Autor(a) principal: Viana, Thamila Arianny Carlos
• Data de Publicação: 2019
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/35780
• topic: Atrial fibrilation; lncRNA; biomarkers; regulatory mechanisms

Background: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role.