Tenascin and fibronectin in pleomorphic adenoma of the salivary gland

Detalhes bibliográficos
Autor(a) principal: Bento, Patrícia Meira
Data de Publicação: 2006
Outros Autores: Freitas, Roseana de Almeida, Pinto, Leão Pereira, Souza, Lélia Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/23896
http://dx.doi.org/10.1590/S1678-77572006000300010
Resumo: Objectives: To analyze the expression and distribution pattern of extracellular matrix components in leomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. Methods and Results: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. Conclusions: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.
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spelling Bento, Patrícia MeiraFreitas, Roseana de AlmeidaPinto, Leão PereiraSouza, Lélia Batista de2017-09-15T14:02:18Z2017-09-15T14:02:18Z2006BENTO, Patrícia Meira et al. Tenascin and fibronectin in pleomorphic adenoma of the salivary gland. Journal of Applied Oral Science, v. 14, n. 3, p. 198-202, 2006.https://repositorio.ufrn.br/jspui/handle/123456789/23896http://dx.doi.org/10.1590/S1678-77572006000300010Objectives: To analyze the expression and distribution pattern of extracellular matrix components in leomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. Methods and Results: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. Conclusions: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.Objetivo: Analisar a expressão e o padrão de distribuição de componentes da matriz extracelular em adenomas pleomórficos de glândula salivar maior e menor e comparar os achados morfológicos destes tumores com a expressão imuno-histoquímica considerando os diferentes tipos de estromas presentes em cada caso. Métodos e Resultados: A expressão da tenascina (TN) e fibronectina (FN) foi analisada em 23 casos de adenomas pleomórficos, sendo 11 tumores em glândula salivar maior e 12 em glândula salivar menor, utilizando-se o método da estreptoavidina-biotina para os anticorpos anti-tenascina e anti-fibronectina. Os resultados imuno-histoquimicos foram correlacionados com os achados morfológicos das lesões. Todos os casos foram imunorreativos para a fibronectina mostrando forte expressão nos estromas fibrosos e condróides, embora fraca marcação tenha sido evidenciada nos estromas hialinos e mixóides. A expressão da tenascina foi mais intensa nos estromas condróides e fibrosos, sendo moderada nos estromas hialino e mixóide. Conclusões: Não houve diferença na expressão destas proteínas entre os tumores de glândula salivar maior e menor.engExtracellular matrixFibronectinTenascinPleomorphic adenomaSalivary gland neoplasiaTenascin and fibronectin in pleomorphic adenoma of the salivary glandinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALTenascinFibronectinPleomorphic_Bento_2006.pdfTenascinFibronectinPleomorphic_Bento_2006.pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000300010application/pdf76247https://repositorio.ufrn.br/bitstream/123456789/23896/1/TenascinFibronectinPleomorphic_Bento_2006.pdf62d2fc0230d39a26caa4b86e5662edeeMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23896/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTTENASCIN AND FIBRONECTIN IN PLEOMORPHIC.pdf.txtTENASCIN AND FIBRONECTIN IN PLEOMORPHIC.pdf.txtExtracted texttext/plain21797https://repositorio.ufrn.br/bitstream/123456789/23896/5/TENASCIN%20AND%20FIBRONECTIN%20IN%20PLEOMORPHIC.pdf.txt728c2d58f68a0b9fcea46af9977cc176MD55THUMBNAILTENASCIN AND FIBRONECTIN IN PLEOMORPHIC.pdf.jpgTENASCIN AND FIBRONECTIN IN PLEOMORPHIC.pdf.jpgIM Thumbnailimage/jpeg6907https://repositorio.ufrn.br/bitstream/123456789/23896/6/TENASCIN%20AND%20FIBRONECTIN%20IN%20PLEOMORPHIC.pdf.jpg533d76b5d97bd4f6ef63013fbd84ed9fMD56123456789/238962021-12-07 12:36:46.976oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-07T15:36:46Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
spellingShingle Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
Bento, Patrícia Meira
Extracellular matrix
Fibronectin
Tenascin
Pleomorphic adenoma
Salivary gland neoplasia
title_short Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_full Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_fullStr Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_full_unstemmed Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_sort Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
author Bento, Patrícia Meira
author_facet Bento, Patrícia Meira
Freitas, Roseana de Almeida
Pinto, Leão Pereira
Souza, Lélia Batista de
author_role author
author2 Freitas, Roseana de Almeida
Pinto, Leão Pereira
Souza, Lélia Batista de
author2_role author
author
author
dc.contributor.author.fl_str_mv Bento, Patrícia Meira
Freitas, Roseana de Almeida
Pinto, Leão Pereira
Souza, Lélia Batista de
dc.subject.por.fl_str_mv Extracellular matrix
Fibronectin
Tenascin
Pleomorphic adenoma
Salivary gland neoplasia
topic Extracellular matrix
Fibronectin
Tenascin
Pleomorphic adenoma
Salivary gland neoplasia
description Objectives: To analyze the expression and distribution pattern of extracellular matrix components in leomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. Methods and Results: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. Conclusions: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2017-09-15T14:02:18Z
dc.date.available.fl_str_mv 2017-09-15T14:02:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BENTO, Patrícia Meira et al. Tenascin and fibronectin in pleomorphic adenoma of the salivary gland. Journal of Applied Oral Science, v. 14, n. 3, p. 198-202, 2006.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/23896
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S1678-77572006000300010
identifier_str_mv BENTO, Patrícia Meira et al. Tenascin and fibronectin in pleomorphic adenoma of the salivary gland. Journal of Applied Oral Science, v. 14, n. 3, p. 198-202, 2006.
url https://repositorio.ufrn.br/jspui/handle/123456789/23896
http://dx.doi.org/10.1590/S1678-77572006000300010
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