Tenascin and fibronectin in pleomorphic adenoma of the salivary gland

Detalhes bibliográficos
Autor(a) principal: Bento,Patrícia Meira
Data de Publicação: 2006
Outros Autores: Freitas,Roseana de Almeida, Pinto,Leão Pereira, Souza,Lélia Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000300010
Resumo: OBJECTIVES: To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. METHODS AND RESULTS: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. CONCLUSIONS: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.
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spelling Tenascin and fibronectin in pleomorphic adenoma of the salivary glandExtracellular matrixFibronectinTenascinPleomorphic adenomaSalivary gland neoplasiaOBJECTIVES: To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. METHODS AND RESULTS: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. CONCLUSIONS: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.Faculdade De Odontologia De Bauru - USP2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000300010Journal of Applied Oral Science v.14 n.3 2006reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572006000300010info:eu-repo/semantics/openAccessBento,Patrícia MeiraFreitas,Roseana de AlmeidaPinto,Leão PereiraSouza,Lélia Batista deeng2006-08-14T00:00:00Zoai:scielo:S1678-77572006000300010Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2006-08-14T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
spellingShingle Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
Bento,Patrícia Meira
Extracellular matrix
Fibronectin
Tenascin
Pleomorphic adenoma
Salivary gland neoplasia
title_short Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_full Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_fullStr Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_full_unstemmed Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
title_sort Tenascin and fibronectin in pleomorphic adenoma of the salivary gland
author Bento,Patrícia Meira
author_facet Bento,Patrícia Meira
Freitas,Roseana de Almeida
Pinto,Leão Pereira
Souza,Lélia Batista de
author_role author
author2 Freitas,Roseana de Almeida
Pinto,Leão Pereira
Souza,Lélia Batista de
author2_role author
author
author
dc.contributor.author.fl_str_mv Bento,Patrícia Meira
Freitas,Roseana de Almeida
Pinto,Leão Pereira
Souza,Lélia Batista de
dc.subject.por.fl_str_mv Extracellular matrix
Fibronectin
Tenascin
Pleomorphic adenoma
Salivary gland neoplasia
topic Extracellular matrix
Fibronectin
Tenascin
Pleomorphic adenoma
Salivary gland neoplasia
description OBJECTIVES: To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. METHODS AND RESULTS: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. CONCLUSIONS: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.
publishDate 2006
dc.date.none.fl_str_mv 2006-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000300010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572006000300010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.14 n.3 2006
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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