Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/23860 |
Resumo: | Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P .05). Conclusion. MMPs-1, 7 and 26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome. |
id |
UFRN_d3b6bb907d262e77039a3a61eae3505a |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/23860 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Cavalcante, Roberta BarrosoAlves, Karuza MariaNonaka, Cassiano Francisco WeegeSouza, Lélia Batista de2017-09-13T15:24:47Z2017-09-13T15:24:47Z2008CAVALCANTE, Roberta Barroso et al . Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 1, p. 923-929, 2008.https://repositorio.ufrn.br/jspui/handle/123456789/2386010.1016/j.tripleo.2007.12.028engImmunohistochemistryImmunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocystsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleObjective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P .05). Conclusion. MMPs-1, 7 and 26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23860/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALImmunohistochemicaldExpressionMMPs_Cavalcante_2008.pdfImmunohistochemicaldExpressionMMPs_Cavalcante_2008.pdfhttp://www.sciencedirect.com/science/article/pii/S1079210407009900?via%3Dihubapplication/pdf785670https://repositorio.ufrn.br/bitstream/123456789/23860/1/ImmunohistochemicaldExpressionMMPs_Cavalcante_2008.pdfc4937166b51672802eb9de7ad5baabe7MD51TEXTImmunohistochemical expression of MMPs.pdf.txtImmunohistochemical expression of MMPs.pdf.txtExtracted texttext/plain31954https://repositorio.ufrn.br/bitstream/123456789/23860/5/Immunohistochemical%20expression%20of%20MMPs.pdf.txtac9fd7ab36acaf8818c72578dda1a431MD55THUMBNAILImmunohistochemical expression of MMPs.pdf.jpgImmunohistochemical expression of MMPs.pdf.jpgIM Thumbnailimage/jpeg11868https://repositorio.ufrn.br/bitstream/123456789/23860/6/Immunohistochemical%20expression%20of%20MMPs.pdf.jpg0e499ccec3413ae56b6a411c0c4bd2d5MD56123456789/238602021-12-09 13:16:21.006oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-09T16:16:21Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
title |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
spellingShingle |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts Cavalcante, Roberta Barroso Immunohistochemistry |
title_short |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
title_full |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
title_fullStr |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
title_full_unstemmed |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
title_sort |
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts |
author |
Cavalcante, Roberta Barroso |
author_facet |
Cavalcante, Roberta Barroso Alves, Karuza Maria Nonaka, Cassiano Francisco Weege Souza, Lélia Batista de |
author_role |
author |
author2 |
Alves, Karuza Maria Nonaka, Cassiano Francisco Weege Souza, Lélia Batista de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cavalcante, Roberta Barroso Alves, Karuza Maria Nonaka, Cassiano Francisco Weege Souza, Lélia Batista de |
dc.subject.por.fl_str_mv |
Immunohistochemistry |
topic |
Immunohistochemistry |
description |
Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P .05). Conclusion. MMPs-1, 7 and 26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2017-09-13T15:24:47Z |
dc.date.available.fl_str_mv |
2017-09-13T15:24:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAVALCANTE, Roberta Barroso et al . Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 1, p. 923-929, 2008. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23860 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.tripleo.2007.12.028 |
identifier_str_mv |
CAVALCANTE, Roberta Barroso et al . Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 1, p. 923-929, 2008. 10.1016/j.tripleo.2007.12.028 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23860 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/23860/2/license.txt https://repositorio.ufrn.br/bitstream/123456789/23860/1/ImmunohistochemicaldExpressionMMPs_Cavalcante_2008.pdf https://repositorio.ufrn.br/bitstream/123456789/23860/5/Immunohistochemical%20expression%20of%20MMPs.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/23860/6/Immunohistochemical%20expression%20of%20MMPs.pdf.jpg |
bitstream.checksum.fl_str_mv |
8a4605be74aa9ea9d79846c1fba20a33 c4937166b51672802eb9de7ad5baabe7 ac9fd7ab36acaf8818c72578dda1a431 0e499ccec3413ae56b6a411c0c4bd2d5 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1797777160097759232 |