The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis

Detalhes bibliográficos
Autor(a) principal: Azevedo, Kesley Pablo Morais de
Data de Publicação: 2020
Outros Autores: Oliveira, Victor Hugo de, Medeiros, Gidyenne Christine Bandeira Silva de, Mata, Ádala Nayana de Sousa, García, Daniel Ángel, Martínez, Daniel Guillén, Leitão, José Carlos, Knackfuss, Maria Irany, Piuvezam, Grasiela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/31177
Resumo: The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I2 = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding
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spelling Azevedo, Kesley Pablo Morais deOliveira, Victor Hugo deMedeiros, Gidyenne Christine Bandeira Silva deMata, Ádala Nayana de SousaGarcía, Daniel ÁngelMartínez, Daniel GuillénLeitão, José CarlosKnackfuss, Maria IranyPiuvezam, Grasiela2021-01-05T13:03:38Z2021-01-05T13:03:38Z2020-08-20AZEVEDO, Kesley Pablo Morais de; OLIVEIRA, Victor Hugo de; MEDEIROS, Gidyenne Christine Bandeira Silva de; MATA, Ádala Nayana de Sousa; GARCÍA, Daniel Ángel; MARTÍNEZ, Daniel Guillén; LEITÃO, José Carlos; KNACKFUSS, Maria Irany; PIUVEZAM, Grasiela. The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis. International Journal of Environmental Research and Public Health, [s. l.], v. 17, p. 6056, 2020. Disponível em: https://www.mdpi.com/1660-4601/17/17/6056. Acesso em: 17 dez. 2020. https://doi.org/10.3390/ijerph171760561660-4601https://repositorio.ufrn.br/handle/123456789/3117710.3390/ijerph17176056MDPIAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessExerciseBrain-derived neurotrophic factorBDNFAdolescentSystematic reviewMeta-analysisThe effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I2 = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. 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dc.title.pt_BR.fl_str_mv The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
title The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
spellingShingle The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
Azevedo, Kesley Pablo Morais de
Exercise
Brain-derived neurotrophic factor
BDNF
Adolescent
Systematic review
Meta-analysis
title_short The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
title_full The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
title_fullStr The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
title_full_unstemmed The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
title_sort The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis
author Azevedo, Kesley Pablo Morais de
author_facet Azevedo, Kesley Pablo Morais de
Oliveira, Victor Hugo de
Medeiros, Gidyenne Christine Bandeira Silva de
Mata, Ádala Nayana de Sousa
García, Daniel Ángel
Martínez, Daniel Guillén
Leitão, José Carlos
Knackfuss, Maria Irany
Piuvezam, Grasiela
author_role author
author2 Oliveira, Victor Hugo de
Medeiros, Gidyenne Christine Bandeira Silva de
Mata, Ádala Nayana de Sousa
García, Daniel Ángel
Martínez, Daniel Guillén
Leitão, José Carlos
Knackfuss, Maria Irany
Piuvezam, Grasiela
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo, Kesley Pablo Morais de
Oliveira, Victor Hugo de
Medeiros, Gidyenne Christine Bandeira Silva de
Mata, Ádala Nayana de Sousa
García, Daniel Ángel
Martínez, Daniel Guillén
Leitão, José Carlos
Knackfuss, Maria Irany
Piuvezam, Grasiela
dc.subject.por.fl_str_mv Exercise
Brain-derived neurotrophic factor
BDNF
Adolescent
Systematic review
Meta-analysis
topic Exercise
Brain-derived neurotrophic factor
BDNF
Adolescent
Systematic review
Meta-analysis
description The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I2 = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding
publishDate 2020
dc.date.issued.fl_str_mv 2020-08-20
dc.date.accessioned.fl_str_mv 2021-01-05T13:03:38Z
dc.date.available.fl_str_mv 2021-01-05T13:03:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv AZEVEDO, Kesley Pablo Morais de; OLIVEIRA, Victor Hugo de; MEDEIROS, Gidyenne Christine Bandeira Silva de; MATA, Ádala Nayana de Sousa; GARCÍA, Daniel Ángel; MARTÍNEZ, Daniel Guillén; LEITÃO, José Carlos; KNACKFUSS, Maria Irany; PIUVEZAM, Grasiela. The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis. International Journal of Environmental Research and Public Health, [s. l.], v. 17, p. 6056, 2020. Disponível em: https://www.mdpi.com/1660-4601/17/17/6056. Acesso em: 17 dez. 2020. https://doi.org/10.3390/ijerph17176056
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/31177
dc.identifier.issn.none.fl_str_mv 1660-4601
dc.identifier.doi.none.fl_str_mv 10.3390/ijerph17176056
identifier_str_mv AZEVEDO, Kesley Pablo Morais de; OLIVEIRA, Victor Hugo de; MEDEIROS, Gidyenne Christine Bandeira Silva de; MATA, Ádala Nayana de Sousa; GARCÍA, Daniel Ángel; MARTÍNEZ, Daniel Guillén; LEITÃO, José Carlos; KNACKFUSS, Maria Irany; PIUVEZAM, Grasiela. The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis. International Journal of Environmental Research and Public Health, [s. l.], v. 17, p. 6056, 2020. Disponível em: https://www.mdpi.com/1660-4601/17/17/6056. Acesso em: 17 dez. 2020. https://doi.org/10.3390/ijerph17176056
1660-4601
10.3390/ijerph17176056
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