Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke
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Publication Date: | 2011 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRN |
Download full: | https://repositorio.ufrn.br/jspui/handle/123456789/23166 |
Summary: | Collateral circulation, defined as the supplementary vascular network that maintains cerebral blood flow (CBF) when the main vessels fail, constitutes one important defense mechanism of the brain against ischemic stroke. In the present study, continuous arterial spin labeling (CASL) was used to quantify CBF and obtain perfusion territory maps of the major cerebral arteries in spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) controls. Results show that both WKY and SHR have complementary, yet significantly asymmetric perfusion territories. Right or left dominances were observed in territories of the anterior (ACA), middle and posterior cerebral arteries, and the thalamic artery. Magnetic resonance angiography showed that some of the asymmetries were correlated with variations of the ACA. The leptomeningeal circulation perfusing the outer layers of the cortex was observed as well. Significant and permanent changes in perfusion territories were obtained after temporary occlusion of the right middle cerebral artery in both SHR and WKY, regardless of their particular dominance. However, animals with right dominance presented a larger volume change of the left perfusion territory (23±9%) than animals with left dominance (7±5%, P<0.002). The data suggest that animals with contralesional dominance primarily safeguard local CBF values with small changes in contralesional perfusion territory, while animals with ipsilesional dominance show a reversal of dominance and a substantial increase in contralesional perfusion territory. These findings show the usefulness of CASL to probe the collateral circulation. |
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Leoni, Renata F.Paiva, Fernando F.Kang, Byeong-TeckHenning, Erica C.Nascimento, George CarlosTannús, AlbertoAraújo, Dráulio Barros deSilva, Afonso C.2017-05-29T12:42:04Z2017-05-29T12:42:04Z20111868-4483https://repositorio.ufrn.br/jspui/handle/123456789/23166engCerebral blood flowCollateral flowMagnetic resonance imagingVascular territoryArterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Strokeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCollateral circulation, defined as the supplementary vascular network that maintains cerebral blood flow (CBF) when the main vessels fail, constitutes one important defense mechanism of the brain against ischemic stroke. In the present study, continuous arterial spin labeling (CASL) was used to quantify CBF and obtain perfusion territory maps of the major cerebral arteries in spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) controls. Results show that both WKY and SHR have complementary, yet significantly asymmetric perfusion territories. Right or left dominances were observed in territories of the anterior (ACA), middle and posterior cerebral arteries, and the thalamic artery. Magnetic resonance angiography showed that some of the asymmetries were correlated with variations of the ACA. The leptomeningeal circulation perfusing the outer layers of the cortex was observed as well. Significant and permanent changes in perfusion territories were obtained after temporary occlusion of the right middle cerebral artery in both SHR and WKY, regardless of their particular dominance. However, animals with right dominance presented a larger volume change of the left perfusion territory (23±9%) than animals with left dominance (7±5%, P<0.002). The data suggest that animals with contralesional dominance primarily safeguard local CBF values with small changes in contralesional perfusion territory, while animals with ipsilesional dominance show a reversal of dominance and a substantial increase in contralesional perfusion territory. These findings show the usefulness of CASL to probe the collateral circulation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALArterial Spin Labeling Measurements of Cerebral Perfusion.pdfArterial Spin Labeling Measurements of Cerebral Perfusion.pdfArtigo completoapplication/pdf685050https://repositorio.ufrn.br/bitstream/123456789/23166/1/Arterial%20Spin%20Labeling%20Measurements%20of%20Cerebral%20Perfusion.pdfc58600c29761d35ed5aee499fd8fa9e9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23166/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTArterial Spin Labeling Measurements of Cerebral Perfusion.pdf.txtArterial Spin Labeling Measurements of Cerebral Perfusion.pdf.txtExtracted texttext/plain50108https://repositorio.ufrn.br/bitstream/123456789/23166/5/Arterial%20Spin%20Labeling%20Measurements%20of%20Cerebral%20Perfusion.pdf.txtdf968ddd9276a7153f80700a49b932f3MD55THUMBNAILArterial Spin Labeling Measurements of Cerebral Perfusion.pdf.jpgArterial Spin Labeling Measurements of Cerebral Perfusion.pdf.jpgIM Thumbnailimage/jpeg8388https://repositorio.ufrn.br/bitstream/123456789/23166/6/Arterial%20Spin%20Labeling%20Measurements%20of%20Cerebral%20Perfusion.pdf.jpgba8f88a20aec71ab3c9499bf520863abMD56123456789/231662021-07-08 15:52:21.771oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T18:52:21Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
title |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
spellingShingle |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke Leoni, Renata F. Cerebral blood flow Collateral flow Magnetic resonance imaging Vascular territory |
title_short |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
title_full |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
title_fullStr |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
title_full_unstemmed |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
title_sort |
Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke |
author |
Leoni, Renata F. |
author_facet |
Leoni, Renata F. Paiva, Fernando F. Kang, Byeong-Teck Henning, Erica C. Nascimento, George Carlos Tannús, Alberto Araújo, Dráulio Barros de Silva, Afonso C. |
author_role |
author |
author2 |
Paiva, Fernando F. Kang, Byeong-Teck Henning, Erica C. Nascimento, George Carlos Tannús, Alberto Araújo, Dráulio Barros de Silva, Afonso C. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Leoni, Renata F. Paiva, Fernando F. Kang, Byeong-Teck Henning, Erica C. Nascimento, George Carlos Tannús, Alberto Araújo, Dráulio Barros de Silva, Afonso C. |
dc.subject.por.fl_str_mv |
Cerebral blood flow Collateral flow Magnetic resonance imaging Vascular territory |
topic |
Cerebral blood flow Collateral flow Magnetic resonance imaging Vascular territory |
description |
Collateral circulation, defined as the supplementary vascular network that maintains cerebral blood flow (CBF) when the main vessels fail, constitutes one important defense mechanism of the brain against ischemic stroke. In the present study, continuous arterial spin labeling (CASL) was used to quantify CBF and obtain perfusion territory maps of the major cerebral arteries in spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) controls. Results show that both WKY and SHR have complementary, yet significantly asymmetric perfusion territories. Right or left dominances were observed in territories of the anterior (ACA), middle and posterior cerebral arteries, and the thalamic artery. Magnetic resonance angiography showed that some of the asymmetries were correlated with variations of the ACA. The leptomeningeal circulation perfusing the outer layers of the cortex was observed as well. Significant and permanent changes in perfusion territories were obtained after temporary occlusion of the right middle cerebral artery in both SHR and WKY, regardless of their particular dominance. However, animals with right dominance presented a larger volume change of the left perfusion territory (23±9%) than animals with left dominance (7±5%, P<0.002). The data suggest that animals with contralesional dominance primarily safeguard local CBF values with small changes in contralesional perfusion territory, while animals with ipsilesional dominance show a reversal of dominance and a substantial increase in contralesional perfusion territory. These findings show the usefulness of CASL to probe the collateral circulation. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2017-05-29T12:42:04Z |
dc.date.available.fl_str_mv |
2017-05-29T12:42:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/23166 |
dc.identifier.issn.none.fl_str_mv |
1868-4483 |
identifier_str_mv |
1868-4483 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/23166 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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