Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/55832 http://dx.doi.org/10.1016/j.clnesp.2022.12.013 |
Resumo: | Aim: This study aims to evaluate the effect of early nutritional intervention on adverse clinical events in women with breast cancer undergoing neoadjuvant chemotherapy. Design and settings: This is a randomized clinical trial performed at the beginning of neoadjuvant chemotherapy for women with breast cancer treated at an oncology referral center (Brazil) and followed until the end of radiotherapy period, at least. Registered under ClinicalTrials.gov Identifier no. RBR3SHHXS. Methods: Participants were allocated to a control group - CG (nutritional guidance on healthy eating practices) or an intervention group - IC (nutritional guidance and individualized food plan). Chemotherapy toxicity (primary endpoint) was considered a precocious adverse clinical event and it was evaluated by self-reported gastrointestinal symptoms observed at any time during the first three cycles of treatment. Post-surgical complications, radiotherapy toxicity, and weight change were considered long-term adverse events. Results: 34 women (19 in the IG and 15 in the CG) were evaluated. The early nutritional intervention was associated with low gastrointestinal chemotoxicity (nausea, vomiting, and constipation, p < 0.001, p < 0.048, and p < 0.024, respectively). However, there were no statically significant differences between both groups in the presence of long-term adverse events (radiotherapy toxicity-88.2% vs 76.9%, weight loss-21.1% vs 26.7% for IC and CG respectively, p > 0.05 for both). Conclusion: The early nutritional intervention was associated with a low frequency of precocious events, but not with long-term adverse events in women with breast cancer during treatment |
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Fayh, Ana Paula TrussardiBezerra, Agnes Denise de LimaSousa, Iasmin Matias deSouza, Ana Priscilla Silva deCarvalho, Ana Lúcia Miranda de2023-12-13T00:31:57Z2023-12-13T00:31:57Z2023-02BEZERRA, Agnes Denise de Lima; SOUSA, Iasmin Matias de; SOUZA, Ana Priscilla Silva de; CARVALHO, Ana Lúcia Miranda de; FAYH, Ana Paula Trussardi. Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study. Clinical Nutrition Espen, [S.l.], v. 53, p. 268-273, fev. 2023. DOI: 10.1016/j.clnesp.2022.12.013. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405457722014231?via%3Dihub. Acesso em: 12 dez. 2023.https://repositorio.ufrn.br/handle/123456789/55832http://dx.doi.org/10.1016/j.clnesp.2022.12.013Clinical Nutrition ESPENNeoplasmtoxicitydietnutritionbody weightdisease-free survivalEarly nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAim: This study aims to evaluate the effect of early nutritional intervention on adverse clinical events in women with breast cancer undergoing neoadjuvant chemotherapy. Design and settings: This is a randomized clinical trial performed at the beginning of neoadjuvant chemotherapy for women with breast cancer treated at an oncology referral center (Brazil) and followed until the end of radiotherapy period, at least. Registered under ClinicalTrials.gov Identifier no. RBR3SHHXS. Methods: Participants were allocated to a control group - CG (nutritional guidance on healthy eating practices) or an intervention group - IC (nutritional guidance and individualized food plan). Chemotherapy toxicity (primary endpoint) was considered a precocious adverse clinical event and it was evaluated by self-reported gastrointestinal symptoms observed at any time during the first three cycles of treatment. Post-surgical complications, radiotherapy toxicity, and weight change were considered long-term adverse events. Results: 34 women (19 in the IG and 15 in the CG) were evaluated. The early nutritional intervention was associated with low gastrointestinal chemotoxicity (nausea, vomiting, and constipation, p < 0.001, p < 0.048, and p < 0.024, respectively). However, there were no statically significant differences between both groups in the presence of long-term adverse events (radiotherapy toxicity-88.2% vs 76.9%, weight loss-21.1% vs 26.7% for IC and CG respectively, p > 0.05 for both). Conclusion: The early nutritional intervention was associated with a low frequency of precocious events, but not with long-term adverse events in women with breast cancer during treatmentengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/55832/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/558322023-12-12 21:32:15.489oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-12-13T00:32:15Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
title |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
spellingShingle |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study Fayh, Ana Paula Trussardi Neoplasm toxicity diet nutrition body weight disease-free survival |
title_short |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
title_full |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
title_fullStr |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
title_full_unstemmed |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
title_sort |
Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study |
author |
Fayh, Ana Paula Trussardi |
author_facet |
Fayh, Ana Paula Trussardi Bezerra, Agnes Denise de Lima Sousa, Iasmin Matias de Souza, Ana Priscilla Silva de Carvalho, Ana Lúcia Miranda de |
author_role |
author |
author2 |
Bezerra, Agnes Denise de Lima Sousa, Iasmin Matias de Souza, Ana Priscilla Silva de Carvalho, Ana Lúcia Miranda de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Fayh, Ana Paula Trussardi Bezerra, Agnes Denise de Lima Sousa, Iasmin Matias de Souza, Ana Priscilla Silva de Carvalho, Ana Lúcia Miranda de |
dc.subject.por.fl_str_mv |
Neoplasm toxicity diet nutrition body weight disease-free survival |
topic |
Neoplasm toxicity diet nutrition body weight disease-free survival |
description |
Aim: This study aims to evaluate the effect of early nutritional intervention on adverse clinical events in women with breast cancer undergoing neoadjuvant chemotherapy. Design and settings: This is a randomized clinical trial performed at the beginning of neoadjuvant chemotherapy for women with breast cancer treated at an oncology referral center (Brazil) and followed until the end of radiotherapy period, at least. Registered under ClinicalTrials.gov Identifier no. RBR3SHHXS. Methods: Participants were allocated to a control group - CG (nutritional guidance on healthy eating practices) or an intervention group - IC (nutritional guidance and individualized food plan). Chemotherapy toxicity (primary endpoint) was considered a precocious adverse clinical event and it was evaluated by self-reported gastrointestinal symptoms observed at any time during the first three cycles of treatment. Post-surgical complications, radiotherapy toxicity, and weight change were considered long-term adverse events. Results: 34 women (19 in the IG and 15 in the CG) were evaluated. The early nutritional intervention was associated with low gastrointestinal chemotoxicity (nausea, vomiting, and constipation, p < 0.001, p < 0.048, and p < 0.024, respectively). However, there were no statically significant differences between both groups in the presence of long-term adverse events (radiotherapy toxicity-88.2% vs 76.9%, weight loss-21.1% vs 26.7% for IC and CG respectively, p > 0.05 for both). Conclusion: The early nutritional intervention was associated with a low frequency of precocious events, but not with long-term adverse events in women with breast cancer during treatment |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-12-13T00:31:57Z |
dc.date.available.fl_str_mv |
2023-12-13T00:31:57Z |
dc.date.issued.fl_str_mv |
2023-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BEZERRA, Agnes Denise de Lima; SOUSA, Iasmin Matias de; SOUZA, Ana Priscilla Silva de; CARVALHO, Ana Lúcia Miranda de; FAYH, Ana Paula Trussardi. Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study. Clinical Nutrition Espen, [S.l.], v. 53, p. 268-273, fev. 2023. DOI: 10.1016/j.clnesp.2022.12.013. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405457722014231?via%3Dihub. Acesso em: 12 dez. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/55832 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1016/j.clnesp.2022.12.013 |
identifier_str_mv |
BEZERRA, Agnes Denise de Lima; SOUSA, Iasmin Matias de; SOUZA, Ana Priscilla Silva de; CARVALHO, Ana Lúcia Miranda de; FAYH, Ana Paula Trussardi. Early nutritional intervention does not prevent long-term adverse events in women with breast cancer: a pilot study. Clinical Nutrition Espen, [S.l.], v. 53, p. 268-273, fev. 2023. DOI: 10.1016/j.clnesp.2022.12.013. Disponível em: https://www.sciencedirect.com/science/article/pii/S2405457722014231?via%3Dihub. Acesso em: 12 dez. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/55832 http://dx.doi.org/10.1016/j.clnesp.2022.12.013 |
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eng |
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Clinical Nutrition ESPEN |
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Clinical Nutrition ESPEN |
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