A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats

Detalhes bibliográficos
Autor(a) principal: Abboud, Renato de Souza
Data de Publicação: 2020
Outros Autores: Chagas, Mauricio Alves, Ribeiro, Ilma Cely de Amorim, Corrêa, Lanna Beatriz Neves Silva, Lange, Raquel Milhomem
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Medicina Veterinária (Recife. Online)
Texto Completo: https://www.journals.ufrpe.br/index.php/medicinaveterinaria/article/view/2410
Resumo: The chemical induction of diabetes mellitus in Wistar rats using alloxan is a commonly adopted scientific method for obtaining experimental models. Although a wide variety of induction protocols have been reported, no standard protocol has been defined due to high mortality rates, reversal, and failure of induction. Therefore, this study proposes an adaptation of the technique to induct diabetes mellitus through a 30-hour fast and a 150 mg/kg dosage of alloxan. The proposed technique has proved to be highly effective.
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spelling A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar ratschemical inductionexperimental diabeteshyperglycemiaalloxan protocol.The chemical induction of diabetes mellitus in Wistar rats using alloxan is a commonly adopted scientific method for obtaining experimental models. Although a wide variety of induction protocols have been reported, no standard protocol has been defined due to high mortality rates, reversal, and failure of induction. Therefore, this study proposes an adaptation of the technique to induct diabetes mellitus through a 30-hour fast and a 150 mg/kg dosage of alloxan. The proposed technique has proved to be highly effective.MEDICINA VETERINÁRIA2020-11-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.journals.ufrpe.br/index.php/medicinaveterinaria/article/view/241010.26605/medvet-v14n4-2410Medicina Veterinária; v. 14 n. 4 (2020); 315-3182675-66171809-4678reponame:Medicina Veterinária (Recife. Online)instname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPEenghttps://www.journals.ufrpe.br/index.php/medicinaveterinaria/article/view/2410/482483812Copyright (c) 2020 Medicina Veterinária (UFRPE)info:eu-repo/semantics/openAccessAbboud, Renato de SouzaChagas, Mauricio AlvesRibeiro, Ilma Cely de AmorimCorrêa, Lanna Beatriz Neves SilvaLange, Raquel Milhomem2020-11-26T11:36:08Zoai:ojs.10.0.7.8:article/2410Revistahttps://www.journals.ufrpe.br/index.php/medicinaveterinaria/PUBhttps://www.journals.ufrpe.br/index.php/medicinaveterinaria/oairevmedvet@ufrpe.br1809-46782675-6617opendoar:2020-11-26T11:36:08Medicina Veterinária (Recife. Online) - Universidade Federal Rural de Pernambuco (UFRPE)false
dc.title.none.fl_str_mv A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
title A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
spellingShingle A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
Abboud, Renato de Souza
chemical induction
experimental diabetes
hyperglycemia
alloxan protocol.
title_short A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
title_full A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
title_fullStr A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
title_full_unstemmed A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
title_sort A modified protocol of the alloxan technique for the induction of diabetes mellitus in Wistar rats
author Abboud, Renato de Souza
author_facet Abboud, Renato de Souza
Chagas, Mauricio Alves
Ribeiro, Ilma Cely de Amorim
Corrêa, Lanna Beatriz Neves Silva
Lange, Raquel Milhomem
author_role author
author2 Chagas, Mauricio Alves
Ribeiro, Ilma Cely de Amorim
Corrêa, Lanna Beatriz Neves Silva
Lange, Raquel Milhomem
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Abboud, Renato de Souza
Chagas, Mauricio Alves
Ribeiro, Ilma Cely de Amorim
Corrêa, Lanna Beatriz Neves Silva
Lange, Raquel Milhomem
dc.subject.por.fl_str_mv chemical induction
experimental diabetes
hyperglycemia
alloxan protocol.
topic chemical induction
experimental diabetes
hyperglycemia
alloxan protocol.
description The chemical induction of diabetes mellitus in Wistar rats using alloxan is a commonly adopted scientific method for obtaining experimental models. Although a wide variety of induction protocols have been reported, no standard protocol has been defined due to high mortality rates, reversal, and failure of induction. Therefore, this study proposes an adaptation of the technique to induct diabetes mellitus through a 30-hour fast and a 150 mg/kg dosage of alloxan. The proposed technique has proved to be highly effective.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.journals.ufrpe.br/index.php/medicinaveterinaria/article/view/2410
10.26605/medvet-v14n4-2410
url https://www.journals.ufrpe.br/index.php/medicinaveterinaria/article/view/2410
identifier_str_mv 10.26605/medvet-v14n4-2410
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.journals.ufrpe.br/index.php/medicinaveterinaria/article/view/2410/482483812
dc.rights.driver.fl_str_mv Copyright (c) 2020 Medicina Veterinária (UFRPE)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Medicina Veterinária (UFRPE)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MEDICINA VETERINÁRIA
publisher.none.fl_str_mv MEDICINA VETERINÁRIA
dc.source.none.fl_str_mv Medicina Veterinária; v. 14 n. 4 (2020); 315-318
2675-6617
1809-4678
reponame:Medicina Veterinária (Recife. Online)
instname:Universidade Federal Rural de Pernambuco (UFRPE)
instacron:UFRPE
instname_str Universidade Federal Rural de Pernambuco (UFRPE)
instacron_str UFRPE
institution UFRPE
reponame_str Medicina Veterinária (Recife. Online)
collection Medicina Veterinária (Recife. Online)
repository.name.fl_str_mv Medicina Veterinária (Recife. Online) - Universidade Federal Rural de Pernambuco (UFRPE)
repository.mail.fl_str_mv revmedvet@ufrpe.br
_version_ 1806552251069628416

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