Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)

Detalhes bibliográficos
Autor(a) principal: Carvalho, Marissa Figueiredo
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://tede.ufrrj.br/jspui/handle/jspui/3664
Resumo: The copaifera glycycarpa (Fabaceae-Caesapinioideaea), popularly known as copaiba cuiarana has its oil used by indigenous peoples in the Xingu region to ease inflammation and infection mainly of skin and throat. The pharmacological activity of Crude Oil (OR) of some species of the genus copaifera activities were shown to have an anti-inflammatory, antinociceptive, gastroprotective, and other antimicrobial and were isolated as cariofilenos and sesquiterpenes and diterpenes as humulenos copaenos, acids and cauren?icos poli?ticos with anti-inflammatory activity and gastroprotective. Considering these indicators, this study aimed to evaluate the potential antinociceptive and anti-inflammatory oleoresin (OR) extracted from the trunk of trees and their isolated C.glycycarpa, kaurenoic acid and acid poli?ltico in pharmacological models in vivo, orally administered in adult male mice weighing 25-35g. In the evaluation of the test antinociceptive, OR (10-1000mg/Kg) decreased in a dose dependent manner the writhings (ID50 = 145.24 mg / kg). The OR decreased both phases in the formalin test, neurogenic pain in 42.30% and pain of inflammatory origin and 69.01% was more efficient in the second phase at the lowest dose at 33.70%. Even in the formalin test, the OR300mg/Kg reduced the reactivity of animals in both phases being more efficient in the second stage 84.78%, the effect being partially reversed by naloxone. In the tail flick test used an opioid agonist and OR30-1000mg/Kg v.o), only the highest dose of 1g/kg (8100 ? 0.5489) increased the time of withdrawal of the tail significantly the stimulus in relation to their vehicle controls (5300 ? 0.3697) and fentanyl (17.80 ? 2023) at the time of evaluation, however not as much as the reference drug. The OR 300mg/kg was shown to have antinociceptive effect by increasing the time to remove the tail and when administered to group pre-treated with p-clorophenilalanina (PCPA100mg/kg ip), reversed the hyperalgesic effect. In assessing anti-inflammatory, pretreatment with increasing doses of OR (10-1000mg/Kg) inhibited dose-dependently and significantly the formation of ear edema induced by croton oil in 79.95%, ID50 calculed 321,34mg/kg, and this activity antiedematogenic shows one more anti-inflammatory property of this OR. In pleurisy test, the pre-treatment with OR (1000mg/Kg acid, and acid kaurenoic 10mg/Kg polialtico 20mg/kg, vo), was able to reduce the number of leukocytes migrate into the pleural cavity at 59.80%, 49.13% and 54.34% respectively, while dexamethasone inhibited 66.64% compared to controls, thereby enhancing these results, anti-inflammatory properties of OR and this inhibition can be at least partly attributed to the activity of these two acids diterpene contained in the OR. Evaluating the action of OR on motor activity and CNS was observed that the OR 300mg/kg had an effect similar to the reference drug diazepam reducing the distance traveled, time of grooming and rearing and increased time in the central and immobility in open-field test a possible mechanism featuring anseolitic and sedative. In addition, the tail suspension test animals pretreated with PCPA, immobility time was significantly higher than in control groups and when received treatment with OR the immobility time of the animal returned to the level of controls showing a possible antidepressant activity of this mixture. Keywords: Copaifera glycycarpa, antinociceptive, anti-inflammatory diterpenes
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spelling Cortes, Wellington da Silvahttp://lattes.cnpq.br/1305510562756172Matheus, Maria ElineMarinho, Bruno Guimar?es026.002.147-47http://lattes.cnpq.br/9205829666689390Carvalho, Marissa Figueiredo2020-06-23T23:33:10Z2012-08-20CARVALHO, Marissa Figueiredo. Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke). 2012. 86 f. Disserta??o (Mestrado Multic?ntrico em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.https://tede.ufrrj.br/jspui/handle/jspui/3664The copaifera glycycarpa (Fabaceae-Caesapinioideaea), popularly known as copaiba cuiarana has its oil used by indigenous peoples in the Xingu region to ease inflammation and infection mainly of skin and throat. The pharmacological activity of Crude Oil (OR) of some species of the genus copaifera activities were shown to have an anti-inflammatory, antinociceptive, gastroprotective, and other antimicrobial and were isolated as cariofilenos and sesquiterpenes and diterpenes as humulenos copaenos, acids and cauren?icos poli?ticos with anti-inflammatory activity and gastroprotective. Considering these indicators, this study aimed to evaluate the potential antinociceptive and anti-inflammatory oleoresin (OR) extracted from the trunk of trees and their isolated C.glycycarpa, kaurenoic acid and acid poli?ltico in pharmacological models in vivo, orally administered in adult male mice weighing 25-35g. In the evaluation of the test antinociceptive, OR (10-1000mg/Kg) decreased in a dose dependent manner the writhings (ID50 = 145.24 mg / kg). The OR decreased both phases in the formalin test, neurogenic pain in 42.30% and pain of inflammatory origin and 69.01% was more efficient in the second phase at the lowest dose at 33.70%. Even in the formalin test, the OR300mg/Kg reduced the reactivity of animals in both phases being more efficient in the second stage 84.78%, the effect being partially reversed by naloxone. In the tail flick test used an opioid agonist and OR30-1000mg/Kg v.o), only the highest dose of 1g/kg (8100 ? 0.5489) increased the time of withdrawal of the tail significantly the stimulus in relation to their vehicle controls (5300 ? 0.3697) and fentanyl (17.80 ? 2023) at the time of evaluation, however not as much as the reference drug. The OR 300mg/kg was shown to have antinociceptive effect by increasing the time to remove the tail and when administered to group pre-treated with p-clorophenilalanina (PCPA100mg/kg ip), reversed the hyperalgesic effect. In assessing anti-inflammatory, pretreatment with increasing doses of OR (10-1000mg/Kg) inhibited dose-dependently and significantly the formation of ear edema induced by croton oil in 79.95%, ID50 calculed 321,34mg/kg, and this activity antiedematogenic shows one more anti-inflammatory property of this OR. In pleurisy test, the pre-treatment with OR (1000mg/Kg acid, and acid kaurenoic 10mg/Kg polialtico 20mg/kg, vo), was able to reduce the number of leukocytes migrate into the pleural cavity at 59.80%, 49.13% and 54.34% respectively, while dexamethasone inhibited 66.64% compared to controls, thereby enhancing these results, anti-inflammatory properties of OR and this inhibition can be at least partly attributed to the activity of these two acids diterpene contained in the OR. Evaluating the action of OR on motor activity and CNS was observed that the OR 300mg/kg had an effect similar to the reference drug diazepam reducing the distance traveled, time of grooming and rearing and increased time in the central and immobility in open-field test a possible mechanism featuring anseolitic and sedative. In addition, the tail suspension test animals pretreated with PCPA, immobility time was significantly higher than in control groups and when received treatment with OR the immobility time of the animal returned to the level of controls showing a possible antidepressant activity of this mixture. Keywords: Copaifera glycycarpa, antinociceptive, anti-inflammatory diterpenesA copaifera glycycarpa(Fabaceae-Caesapinioideaea), popularmente conhecida como copa?ba cuiarana tem seu ?leo utilizado por popula??es ind?genas da regi?o do Xingu para amenizar inflama??es e infec??es principalmente de pele e garganta . A atividade farmacol?gica do ?leo Bruto (OR) de algumas esp?cies do g?nero copaifera j? demonstraram ter atividades ati-inflamat?ria, antinociceptiva, gastroprotetora, antimicrobiana entre outras, bem como foram isolados sesquiterpenos como cariofilenos e humulenos e diterpenos como copaenos, ?cidos cauren?icos e poli?ticos com atividade anti-inflamat?ria e gastroprotetora. Considerando estes indicativos, este trabalho objetivou avaliar o potencial antinociceptivo e anti-inflamat?rio da ?leo-resina(OR) extra?do do tronco de ?rvores de C.glycycarpa e de seus isolados ?cido cauren?ico e ?cido poli?ltico em modelos farmacol?gicos in vivo, administrados por via oral em camundongos machos adultos pesando entre 25-35g. Na avalia??o antinociceptiva pelo teste das contor??es abdominais, a OR(10-1000mg/kg) reduziu de maneira dose dependente as contor??es(DI50%=145,24mg/kg). A OR reduziu ambas fases no teste da formalina, a dor neurog?nica em 42,30% e a dor de origem inflamat?ria 69,01% sendo mais efeci?nte na segunda fase na menor dose em 33,70%. Ainda no teste da formalina, a OR300mg/kg reduziu o tempo de reatividade dos animais em ambas fases sendo mais eficiente na segunda fase 84,78%, sendo este efeito parcialmente revertido pela naloxona. No teste da retirada de cauda utilizado um agonista opi?ide e OR30-1000mg/kg v.o), apenas a dose mais alta de 1g/kg(8.100 ? 0.5489) aumentou o tempo de retirada da cauda significativamente frente ao est?mulo em rela??o aos seus controles ve?culo (5.300?0.3697) e fentanil(17.80?2.023) no mesmo tempo de avalia??o no entanto n?o tanto quanto a droga de refer?ncia. A OR 300mg/kg mostrou ter efeito antinociceptivo aumentando o tempo de retirada da cauda e quando administrada aos grupo pr? tratado com PCPA(100mg/Kg i.p), reverteu o efeito hiperalg?sico. Na avalia??o anti-inflamat?ria, o pr?-tratamento com doses crescentes da OR (10-1000mg/kg)inibiu de forma dose-dependente e significativamente a forma??o do edema de orelha induzida por ?leo de Croton em 79.95% sendo a DI50% de 321,34mg/kg, sendo esta atividade antiedematog?nica mais um efeito que evidencia uma propriedade anti-inflamat?ria desta OR. No teste da pleurisia, o pr?-tratamento com a OR (1000mg/kg, ?cido cauren?ico 10mg/Kg e ?cido polialtico 20mg/kg, v.o), foi capaz de reduzir o n?mero de leuc?citos migrados para a cavidade pleural em 59,80%; 49,13% e 54,34% respectivamente enquanto a dexametasona inibiu 66,64% em rela??o aos controles, refor?ando com estes resultados, as propriedades anti-inflamat?rias da OR e esta inibi??o pode ser pelo menos em parte atribu?da a atividade destes dois ?cidos diterpenos contidos na OR. Avaliando a a??o da OR sobre a atividade motora e Sistema Nervoso Central foi observado que a OR 300mg/kg teve efeito similar ao da droga de refer?ncia diazepam diminuindo a dist?ncia percorrida, o tempo de grooming e rearing e aumentando o tempo na zona central e de imobilidade no teste do campo aberto caracterizando um poss?vel mecanismo anselitico e sedativo. Al?m disso, no teste da suspens?o pela cauda nos animais pr?-tratados com P-clorofenilalanina (PCPA 100mg/kg,i.p), Inibidor da enzima triptofano hidroxilases, o tempo de imobilidade foi significativamente maior que nos grupos controles e quando receberam tratamento com a OR o tempo de imobilidade dos animais retornaram ao n?vel dos controles mostrando uma poss?vel ativividade antidepresiva dessa mistura.Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2020-06-23T23:33:10Z No. of bitstreams: 1 2012 - Marissa Figueiredo Carvalho.pdf: 1955842 bytes, checksum: 019f4712d496b2c362e04ba5d8735011 (MD5)Made available in DSpace on 2020-06-23T23:33:10Z (GMT). No. of bitstreams: 1 2012 - Marissa Figueiredo Carvalho.pdf: 1955842 bytes, checksum: 019f4712d496b2c362e04ba5d8735011 (MD5) Previous issue date: 2012-08-20Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES, Brasil.application/pdfhttps://tede.ufrrj.br/retrieve/60830/2012%20-%20Marissa%20Figueiredo%20Carvalho.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma Multic?ntrico de P?s-Gradua??o em Ci?ncias Fisiol?gicasUFRRJBrasilInstituto de Ci?ncias Biol?gicas e da Sa?deABBAS, A.K., LICHTMAN, A.H. In: Imunologia celular a molecular. Ed, Elsevier quinta edi??o, 2005. AHUMADA, C.; SAENZ, T.; GARCIA, D.; DeLa PUERTA, R.; FERNANDEZ, A. e MARTINEZ, E. The effects of a triterpene fraction isolated from Crataegus monogyna Jacq. on different acute inflammation models in rats and mice. Leucocyte migration and phospholipase A2 inhibition. Journal of Pharmacology. V.49 (3), p.329-331, 1997. AIRES, M. M. e Colabodores ,RJ. Fisiologia. 2008. 3.ed., Rio de Janeiro: Guanabara Koogan p.242-57. ALVES, T. M. A.; CHAVES, P. P. G.; SANTOS, L. M. S. T.; NAGEM, T. J.; MURTA, S. M. F.; CERAVOLO, I. P.; ROMANHA, A. J.; ZANI, C. L. Planta M?dica. V.61, p.85, 1995. APPLETON, I.; TOMLINSON, A.; WILLOUGHBY, D. A. Induction cyclo-oxygenase and nitric oxide synthase in inflammation. Advances in Pharmacology. v.35, p.27?78, 1996. APPOLIN?RIO, P. P.; DEROGIS, P. B. M. C.; YAMAGUTI, T. H.; MIYAMOTO, S. Metabolismo, oxida??o e implica??es biol?gicas do ?cido docosahexaenoico em doen?as neurovegetativas Quimica Nova, v.43, p.1-8, 2011. ARCHER, J. Tests for emotionality in rats and mice: a review. Animal Behavior v.21 (2), p.205-235, 1973. ASHMAWI, H. A.; BRAUN, L. M.; SOUSA, A. M.; POSSO, I. P. Analgesic Effects of H1 Receptor Antagonists in the Rat Model of Formalin-Induced Pain. Revista Brasileira de Anestesioliologia v.59, p.461-70, 2009. BASILE, A. C.; SERTI?, J. A.; FREITAS, P.C. D.; ZANINI, A. C. Anti.inflammatory activity ofoilresin from Brazilian Copaifera. Jornal of Ethnopharmacology v.22, p.101-109, 1988. BHATIA, M.; WONG, F. L.; CAO, Y.; LAU, H. Y.; HUANG, J.; PUNEET, P. Pathophysiology of acute pancreatitis. Pancreatology. v.5, p.132?44, 2005. BOLLER, S.; SOLDI, C.; MARQUES, M. C. A.; SANTOS, E. P.; CABRINI, D. A.; PIZZOLATTI, M. G.; ZAMPRONIO, A. R.; OTUKI, M. F. Anti-inflamatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. Journal of Ethnophamacology. v.130, p.262-266, 2010. BOISSIER, J. R. e SIMON, P. The exploration reaction in the mouse. Preliminary note. Th?rapie. v.17, p.1225-1232, 1962. BREYER, R. M.; BAGDASSARIAN, C. K.; MYERS, S. A.; BREYER, M. D. Prostanoid receptors: Subtypes and signaling. Annual Review of Pharmacology and Toxicology. v.41, p. 661-90, 2001. BUCHANAN, F. G.; CHANG, W.; SHENG, H.; SHAO, J.; MORROW, J. D. DUBOIS, R. N. Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor. Gastroenterology. v.127, n?5, p.1391?400, 2004. BUT, P. G.; MURAVEV, R. A.; FORMINA, V. A.; ROGOVIN, V. V. Antimicrobial activity of myeloperoxidase from neutrophilic peroxisome. Biological Bulletin. v.29, p.212-15, 2002. CARVALHO, W. A.; LEM?NICA, L. Mecanismos centrais de transmiss?o e de modula??o da dor. Atualiza??o terap?utica. Revista Brasileira de Anestesiologia. v.48, p.221 ? 41, 1998. CASCON, V.; GILBERT, B. Characterization of the Chemical Composition of Oilresins of Copaifera guyanensis Desf., Copaifera duckei Dwyer and Copaifera multijuga Hayne.Phytochemistry. v.55 (7), p.773-778, 2000. CAWTHORN, W. P.; SETHI, J. K. TNF-alpha and adipocyte biology. FEBS Letters. v.582, p.117-31, 2008. CHANDRASEKHARAN, N. V.; DAI, H.; ROOS, K. L.; EVANSON, N. K.; TOMSIK, J. ELTON, T. S. SIMMONS, D. L. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proceedings of National Academy of Sciences USA. v.99, , p.13926?31, 2002. CHARLESWORTH, E. N.; KAGEY-SOBOTKA, A.; SCHLEIMERr, R. P.; NORMAN, P. S.; LICHTENSTEIN, L. M. Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen. The Journal of Immunology v.146, p. 671?76, 1991. CHENG, H. F.; HARRIS, R. C. Cyclooxygenases, the kidney, and hypertension. Hypertension. v.43, p.525?30, 2004. CHOI, R. J.; SHIN, E. M.; JUNG, H. A.; CHOI, J. A.; KIM, Y. S.Inhibitory effects o kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages Phytomedicine v.18; p.677?682, 2011. CLOEZl-TAYARANI, I.; CHANGEUX, J. P. Nicotine and serotonin in immune regulation and inflammatory processes: a perspective. Journal Leukocyte Biology. v.81, p.599?606, 2007. COGGESHALL R.E.; CARLTON, S.M. Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Research Review v.24, p. 28-66, 1997. COSTA, R. Effect of novel selective non-peptide kinin B(1) receptor antagonists on mouse pleurisy induced by carrageenan. Peptides. v. 27, p.2967-75, 2006. CUNHA, K. M. A.; PAIVA, L. A. F; SANTOS F. A; GRAMOSA. N. V; SILVEIRA E. R; RAO, V. S. N Smooth muscle relaxant effect of kaurenoic acid diterpene from copaifera langsdorffii on rat uterus in vitro.Phytotherapy Research.v.17, 2002. CRYAN, J. F.; MOMBEREAU, C.; VASSOUT A. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neuroscience and Behavoral Reviews, 29, p. 571?625, 2005. CURIO, M.; JACONE, H.; PERRUT, J.; PINTO, A. C.; VEIGA FILHO, V. F.; SILVA, R. C. B. Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. DI STASI, L.C. Plana medicinas:Verdades e mentiras.S?o Paulo:Unesp, 2007, p.10-83 DJAHANGUIRI, B. The production of acute gastric ulceration by indomethacin in the rat. Scand. Journal of. Gastroenterology. v.4, p.265-267, 1969. DUBUISSON, D.; DENNIS, S. G. The formalin test:a quantitative study of the analgesic effects of morphine,meperidine,and brain stem stimulation in rats and cats.Pain. v.4,p.161-1174,1977. DUHAM, N. W. e MYIA, T. S. Journal of. American Pharmacology Association. 46, 208, 1957. DWYER, J.D.The Central American West Indian and South American Species of Copaifera (Caesalpiniacea).Brittonia. v.7(3), p.143-172, 1951. FERNANDES, R. M.; PEREIRA, N. A.; PAULO, L. G. Antinflammatory activity of copa?ba balsam(Copaifera Cearensis Huber). Revista Brasileira de Farm?cia. v.73, p.53-56, 1992. GAO, W.; SCHMIDTKO, A.; WOBST, I.; LU, R.; ANGIONI, C.; GEISSLINGER, G. Postaglandin D2 Produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. Journal of Physiology and Pharmacology. v.60, p.145-50, 2009. GAUT, J. P.; YEH, G. C.; TRAN, H. D.; BYUN, J.; HENDERSON, J. P.; RICHTER, G. M.; BRENNAN, M. L.; LUSIS, A. J.; BELAAOUA, A.; HOTCHKISS, R. S.; HEINECKE, J. W. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proceedings of National Academy of Sciences . v.98, p.11961-66, 2001. GIBSON, S. J.; POLAK, J. M.; BLOOM, S. R.; SABATE, I. M.; MULDERRY, P. M.; GHATEI, M. A.; MCGREGOR, G. P.; MORRISON, J. F.; KELLY, J. S.; EVANS, R. M.; ROSENFELD, M. G. Calcitonin-gene related peptide immunoreactivity in the spinal cord of man and eight other species. Journal os Neuroscience. v.4, p.3101? 11, 1984. GIORDANO, J. The Neurobiology of Nociceptive and Anti-nociceptive Systems. Pain Physician v.8, p.277- 90, 2005. GOMES, N. M.; REZENDE ,C. M.; FONTES ,S. P.; MATHEUS, M. E.; FERNANDES, P. D. Antinociceptive activity of Amazonian Copaiba oils. Journal of Ethnopharmacology . v.109, p.486-492, 2007. GOMES, N. M.; REZENDE ,C. M.; FONTES ,S. P.; MATHEUS, M. E.; PINTO, A. C. e FERNANDES, P. D. Characterization f the antinociceptive and antinflammatory activities of fractions obtained from Copaifera multijuga Hayne Journal of Ethnopharmacology v.128, p.177-183, 2010. HARGREAVES, K.; DUBNER, R.; BROWN, F.; FLORES, C.; JORIS, J. A new and sensitive method for measuring thermal nociception in cutaneos hyperalgesia.Pain.v.32 n.1, p.77-78, 1988. HESS, S .; PADOANI, C.; SCORTEGANHA, L. C.; HOLZMANN, I.; MALHEIROS, A. YUNES, R. A.; MONACHE, F. D.; SOUZA, M. M. Assemment of mechanisms involved in Antinoception Caused by Myrsinoic Acid B Biological and Pharmaceutical Bulletim v.33(2), p.209-215, 2010 HILL, S. J.; GANELLIN, C. R.; TIMMERMAN H.; SCHWARTZ, J. C.; SHANKLEY, N. P.; YOUNG, J. M.; SCHUNACK, W.; LEVI, R.; HASS, H. L. International Union of Pharmacology. XIII. Classification of Histamine Receptors. Pharmacology Research. v.49, p.253-78, 1997. HONG, Y.; JI, H.; WEI, H. Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. Pain. v.124, p. 27?33, 2006. HOYER, D.; HANNON, J. P.; MARTIN, G. R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav. v.71, p.533?54, 2002. HUSSAIN, T.; GUPTA, S.; MUKHTAR, H. Cyclooxygenase-2 and prostate carcinogenesis. Cancer Lett. v.191, p.125-35, 2003. HUNSKAAR, S.; FASMER, O. B.; e HOLE, K. Dissociation between antinociceptive and anti-inflamatory effects of acetylsalicylic acid and indomethacin in the formalin test. Journal of Neuroscience. Meth. 14, 69, 1986. HUNSKAAR, S. and HOLE, K. Formalin test in mice: dissociation between antinflammatory and non-inflammatory pain. Pain v.30, p.103-114, 1987. JONES, T. C.; HUNT, R. D.; KING, N. W. Patologia Veterin?ria. 2000. S?o Paulo: Manole JULIUS, D.; BASBAUM, A. I. Molecular mechanisms of nociception. Nature v.413, p203?10, 2001. KALKAN, A.; BULUT, V.; EREL, O.; AVCI, S.; BINGOL, N. K. Adenosine deaminase and guanosine deaminase activities in sera of patients with viral hepatitis.Mem?rias do Instituto Oswaldo Cruz v.94, p.383?6, 1999. KANAOKA, Y.; URADE, Y. Hematopoietic prostaglandin D synthase. Prostaglandins Leukotrienes and Essential Fatty Acids v.69, p.163-7, 2003. KIS, B.; SNIPES, J. A.; ISSE, T.; NAGY, K.; BUSIJA, D. W. Putative cyclooxygenase-3 expression in rat brain cells. Journal of Cerebral Blood Flow and Metabolism. v.23, p.1287?92, 2003. KIS, B.; SNIPES, J. A.; BUSIJA, D. W. Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. Journal Pharmacology Experimental Therapies. v.315, p.1412-14, 2005. KLAUMAN, P. R.; WOUK, A. F. P. F.; SILAS, T. Patofisiologia da dor. Archives of Veterinary Science v.13, p.1-12, 2008. KOSTER,R.; ANDERSON, M.; DE BEER, E. J. Acetic acid for analgesic screening.Federation Proceedings. v.18, p.412 ,1959. KUMAR, V.; ABBAS, A. K.; FAUSTO, N.; ASTER, J. C. ROBBINS and COTRAN-Patologic Basis of Disease, 8th editon, 2010, Elsevier. KURUMBAIL, R. G.; KIEFER, J. R.; MARNETTT, L. J. cyclooxygenase enzymes: catalysis and inhibition. Current Opinion in Structural Biology. v.11, p.752-60, 2001. KUSHNIR-SUKHOV NM, BROWN JM, WU Y, KIRSHENBAUM A, METCALFE DD. Human mast cells are capable of serotonin synthesis and release. Journal of Allergy and Clinical Immunology. v.119(2), p.498?499, 2007. LIM, H.; JUNG, H. A.; CHOI, J. S.; KIM, Y. S.; KANG, S. S.; KIM, H. P. Anti-inflammatory activity of the constituents of the roots of Aralia continentalis Archives of Pharmacological Research v.32, p.1237-1243, 2009 LIMA, S.R.M.; VEIGA, J.R.V.F.;.CHRISTO, H.B.; PINTO, A.C.; FERNANDES, P.D.In vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions.Phytotherapy Research. v.17, p.1048-1053,2003. LIMA, A. RJ. ?ndice Terap?utico Fitoter?pico. 2008. 1 ed.-Petr?polis:EPUB LOCKSLEY, R. M.; KILLEEN, N.; LENARDO, M. J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell v.104, p.487?501, 2001. MACIEL, M.A.M.; PINTO, A.C.; VEIGA JUNIOR, V.F; GRYNBERG, N.F.; ECHEVARRIA, A. Plantas Medicinais:A Necessidade de Estudos Multidisciplinares. Quimica Nova. v.25, n.3, 2002. MAGGI, C. A. Tachykinins and calcitonin gene-related peptide (CGRP) as cotransmitters released from peripheral endings of sensory nerves. Progress in Neurobiology. v.45, p.1-98, 1995. MARTINS-DA-SILVA, R.C.V; PEREIRA, J.F. e LIMA, H.C. O g?nero Copaifera (Leguminosae ? Caesalopinoideae) na Amaz?nia Brasileira.Rodriguesia. v. 59(3), p.455-476, 2008. MIYAZAWA, M.; SHIMAMURA, H.; NAKAMURA, S.; KAMEOKAT,H. Antimutagenic Activity of(+)- Polyalthic Acid from Vitex Rotundiforia Journal of. Agricultural and. Food Chemmistry. v. 43, p.3012-3015, 1995. MELZACK, R.; WALL, P. D. Pain mechanisms: a new theory. Science. v.150, p.971?79, 1965. MESSLINGER, K. What is a nociceptor ? Anaesthesistogy. v.46, p.142-53, 1997. MERSKEY, H.; BOGDUK, N. Classification of chronic pain. Seattle: IASP Press. 1994. MILLAN, M. J. The induction of pain: an integrative review. Progress in Neurobiology v.57, p.1?164, 1999. MILLAN, M. J. Descending control of pain. Progress in Neurobiology v.66, p.355?474, 2002. MURAKAMI, M..; NAKASHIMA, K.; KAMEI, D.; MASUDA, S.; ISHIKAWA, Y.; ISHII, T.; OHMIYA, Y.; WATANABE, K.; KUDO I. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. The Journal of Biological Chemmistry. v.278, p.37937?47, 2002. NEVE, J.; PARIJ, N.; MOGUILEVSKY, N. Inhibition of the myeloperoxidase chlorinating activity by nonsteroidal anti-inflammatory drugs investigated with a human recombinant enzyme. European Journal of Pharmacology. v.417, p.37-43, 2001. PAIVA, L.A.F; RAO, V.S.N.; GRAMOSA, N.V.; SILVEIRA, E.R. Gastroprotective effect of Copaifera langsdorffii ?leo-resin on experimental gastric ulcer models in rats. Journal of Ethnopharmacology. 62 p.73-78, 1998. PAIVA, L.A.F.; GURGEL, L.A.; SILVA, R.M.; TOM?A.R.; GRAMOSA, N.V.; SILVEIRA, E.R.; SANTOS, F.A.; RAO, V.S.N. Anti-inflammatory effects of Kaurenoic acid,a diterpene from copaifera langsdorffii on acetic acid-induced colitis in rats. Vascular pharmacology. v.39, p.303-307, 2003. PAIVA, L. A. F.; GURGEL, L. A.; DE SOUZA, E. T.; SILVEIRA, E. R.; SILVA, R. M.; SANTOS, F. A.; RAO, V. S. N Protective effet of Copaifera langsdorffii oil-resin against acetic-acid-induced colitis in rats. Journal of Ethonopharmacology v.93, p.51-56, 2004 PEREIRA, F.J.; MARTINS, F. T.; CORR?A, R.S.; MOREIRA, M.E.C.; COSTA, A.M.D.D.; DOS SANTOS, M.H.; POLO, M.; BARBOSA, L.C.A. Isolamento, Composi??o Qu?mica e Atividade Anti-inflamat?ria do ?leo Essencial do Pericarpo de Copaifera langsdorffii Desf.de acordo com Hidrodestila??es sucessivas Latin American Journal of Pharmacy v.27(3), p.369-374, 2008. PICOT, D.; LOLL, P. J.; GARAVIT, R. M. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature v.367, p.243-9, 1994. PIERI, F.A.; MUSSI, M.C.; MOREIRA, M.A.S. ?lo de copa?ba (Copaifera sp.): hist?rico, extra??o, aplica??es industriais e propriedades medicinais. Revista Brasileira de Plantas Medicinais (Botucatu) v.11, p.465-472, 2009. PINHEIRO, M M.; BESSA, S. O.; FINGOLO, C. E.; KUSTER, R. M.; MATHEUS, M. E.; MENEZES, F. S. E FERNANDES, P. D.Antinociceptive activity of fractions from Couroupita guianensis Albl. Leaves Journal of Ethnopharmacology. v.127(2), p.407-413, 2010. RAFFA, R. B. Antihistamines as analgesics. Journal of Clinical Pharmacology Therapies. v.26, p.81-5, 2001. RANG, H.P.; DALE, M.M.; RITTER, J.M.; FLOWERS, RJ.Farmacologia.2007.6 ed.,Rio de Janeiro:Elsevier. REYES-TREJO, B.; S?NCHEZ-MENDONZA, M.E.; BECERRA-GARCIA, A.A; CEDILLO-PORTUGAL, E.; CASTILLO-HENKEL, C.; ARRIETA, J. Bioassay-guided isolation of an anti-ulcer diterpenoid from Croton reflexifolius: role of nitric oxide, prostaglandins and sulfhydryls. Journal of pharmacy and pharmacology v.60, p. 931?936, 2008 ROSEN, H.; MICHEL, B. Redundant contribution of myeloperoxidase dependent systems to neutrophilmediated killing of Escherichia coli. Infection and Immunity. v.65, p.4173?8, 1997. SACHETTI, C.G.; FASCINELI, M.L.; SAMPAIO, J.A.; LAMEIRA,O.A.; CALDAS, E.D. Avalia??o da toxicidade aguda e potencial neurot?xico do ?leo-resina de copa?ba (Copaifera reticulata Ducke, Fabaceae) Revista Brasileira de Farmacognosia v.19(4), p. 937-941, 2009 SALEH, T. S. F.; CALIXTO, J. B.; MEDEIROS, Y. S. Pro-inflammatory effects induced by bradikinin in a murine model of pleurisy. European Journal of Pharmacology. v.331, p.43-52, 1997. SCHIANTARELLI, P.; CADEL, S.; ACERBI, D. e PAVESI, L. Antiinflammatory activity and bioavailability of percutaneous piroxicam. Arzneim.-Forsch./Drug Research. v.32 (3), p.230-235, 1982. SERHAN, C.N.; SAVILL, J. Resolution of Inflammation: The beginning programs the end Nature Immunology . v. 6, p.1191-1197, 2005. SERHAN, C.N. Nuevos mediadores qu?micos en la resoluci?n de la inflamaci?n: resolvinas y protectinas Anesthesiology Clinics of North America v.24, p.341-364, 2006. SKILL, N. J.; THEODORAKIS, N. G.; WANG, Y. N.; WU, J. M.; REDMOND, E. M.; Sitzmann, J. V. Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension. American Journal of Gastrointestinal and Liver Physiology. v.295, p.53-64, 2008. SOUZA, P.A.; RANGEL, L. P.; OIGMAN, S. S.; ELIAS, M. M.; FERREIRA-PEREIRA, A.; GARDEN, N. C. L. e LEIT?O, G. G. The Efficient Preparative Isolation of Two Bioactive Diterpenic Acids from Copaifera glycycarpa Ducke Oilresin by High-Speed Counter-Current Chromatography (HSCCC) Using a Non-aqueous Solvent System. Phytochemical Analysis.v.21; p.539-543, 2010. STERU, L.;CHERMAT, R.;THIERRY ,B.; SIMON, P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology V.85(3), p.367-370, 1985. TAPPIN, M. R. R.; PEREIRA, JISLAINE F .G.; LIMA, L. A.; SIANI, A. C.; MAZZEI, J. L.; RAMOS, M. F. S. An?lise qu?mica quantitativa para padroniza??o do ?leo de copa?ba por cromatografia em fase gasosa de alta resolu??o. Qu?mica Nova. v.27, p.236-240, 2004. TINCUSI, B.M.; JIMENEZ, I.A.; BAZZOCCHI, I.L.; MOUJIR, L.M.; MAMANI, Z.A; BARROSO, J.P.; RAVELO, A.G.; HERNANDEZ, B.V. Antimicrobial terpenoids from the oleoresin of the peruvian medicinal plant Copaifera paupera. Planta M?dica. v. 68, p.808-812, 2002. VEIGA JUNIOR V.F.; PATITUCCI, M.L. ; PINTO, A.C. Controle de Autenticidade de ?leos de copa?ba comerciais por cromatografia gasosa de alta resolu??o Qu?mica Nova.v.20, p.612, 1997. VEIGA JUNIOR V. F.; ZUNINO, L.; CALIXTO, J. B.; PATITUCCI, M. L.; PINTO ,A. C. Phytochemical and antiedematogenic studies of comercial copa?ba oil avaible in Brazil.Phytotherapy research. v.15, p.476-480, 2001. VEIGA JUNIOR,V.F.; PINTO,A.C.; O G?nero Copaifera L. Qu?mica Nova.v.25, p.273-286, 2002. VEIGA JUNIOR, V. F.; ROSAS, E. C.; CARVALHO, M. V.; HENRIQUES, M. G. M. O.; PINTO, A. C. Chemical composition and anti-inflamatory activity of copaiba oils from Copaifera cearensis Huber (ex Ducke), Copaifera reticulata Ducke and Copaifera multijuga Hayne ? A comparative study. Journal of Ethnopharmacology. v.112, p.248-254, 2007. VEIGA JUNIOR,V.F.; LEANDRO, L.M.; VARGAS, F.S.; BARBOSA, P.C.S.; NEVES, J.K.O.; SILVA, J.A.; Chemistry and Biological Activities of Terpenois from copaiba (Copaifera spp) Oilresins. Molecules v.17, p. 3866-3889, 2012. VIEIRA, R.C.; BOMBARDIERE, E.; OLIVEIRA, J.J.; LINO-JUNIOR,R.S. BRITO,L.A.B.; JUNQUEIRA-KIPNIS,A.P. INFLU?NCIA DO ?LEO DE Copaifera langsdorffii NO REPARO DE FERIDA CIR?RGICA NA PRESEN?A DE UM CORPO ESTRANHO) Pesquisa Veterin?ria Brasileira. V.28 (8) p.358-366, 2008 WINKELSTEIN, B. A. Mechanisms of central sensitization, neuroimmunology & injury biomechanics in persistent pain: implications for musculoskeletal disorders. Journal of Electromyography and Kinesiology. v.14, p. 87-93,2004. WOOLFE, G. and MACDONALD, A. D. The evaluation of analgesic action of pethidine hydrochloride (DEMEROL) . Jounal of Pharmacology Experimental Therapies. v. 80, p. 300-307, 1944. WOOLF, C.J. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann. Intern. Med v. 140, n. 6, p. 441- 451, 2004. YU, B.; BECNEL, J.; ZERFAOUI, M.; ROHATGI, R.; BOLARES, A. H.; NICHOLS, C. D. Serotonin 5-Hydroxytryptamine 2A Receptor Activation Suppresses Tumor Necrosis Factor-Induced Inflammation with Extraordinary Potency. Journal of Pharmacology Experimental Therapies. v.327, p.316-23, 2008. ZIMMERMANN, M. Ethical considerations in relation to pain in animal experimentation. 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dc.title.por.fl_str_mv Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
dc.title.alternative.por.fl_str_mv Antinociceptive and anti-inflammatory activity of Copaifera Glycycarpa (Ducke) oil-resin
title Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
spellingShingle Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
Carvalho, Marissa Figueiredo
Copaifera glycycarpa
antinociceptivo
anti-inflamat?rio
diterpenos
antinociceptive
anti-inflammatory diterpenes
Biologia Geral
title_short Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
title_full Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
title_fullStr Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
title_full_unstemmed Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
title_sort Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke)
author Carvalho, Marissa Figueiredo
author_facet Carvalho, Marissa Figueiredo
author_role author
dc.contributor.advisor1.fl_str_mv Cortes, Wellington da Silva
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1305510562756172
dc.contributor.referee1.fl_str_mv Matheus, Maria Eline
dc.contributor.referee2.fl_str_mv Marinho, Bruno Guimar?es
dc.contributor.authorID.fl_str_mv 026.002.147-47
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9205829666689390
dc.contributor.author.fl_str_mv Carvalho, Marissa Figueiredo
contributor_str_mv Cortes, Wellington da Silva
Matheus, Maria Eline
Marinho, Bruno Guimar?es
dc.subject.por.fl_str_mv Copaifera glycycarpa
antinociceptivo
anti-inflamat?rio
diterpenos
topic Copaifera glycycarpa
antinociceptivo
anti-inflamat?rio
diterpenos
antinociceptive
anti-inflammatory diterpenes
Biologia Geral
dc.subject.eng.fl_str_mv antinociceptive
anti-inflammatory diterpenes
dc.subject.cnpq.fl_str_mv Biologia Geral
description The copaifera glycycarpa (Fabaceae-Caesapinioideaea), popularly known as copaiba cuiarana has its oil used by indigenous peoples in the Xingu region to ease inflammation and infection mainly of skin and throat. The pharmacological activity of Crude Oil (OR) of some species of the genus copaifera activities were shown to have an anti-inflammatory, antinociceptive, gastroprotective, and other antimicrobial and were isolated as cariofilenos and sesquiterpenes and diterpenes as humulenos copaenos, acids and cauren?icos poli?ticos with anti-inflammatory activity and gastroprotective. Considering these indicators, this study aimed to evaluate the potential antinociceptive and anti-inflammatory oleoresin (OR) extracted from the trunk of trees and their isolated C.glycycarpa, kaurenoic acid and acid poli?ltico in pharmacological models in vivo, orally administered in adult male mice weighing 25-35g. In the evaluation of the test antinociceptive, OR (10-1000mg/Kg) decreased in a dose dependent manner the writhings (ID50 = 145.24 mg / kg). The OR decreased both phases in the formalin test, neurogenic pain in 42.30% and pain of inflammatory origin and 69.01% was more efficient in the second phase at the lowest dose at 33.70%. Even in the formalin test, the OR300mg/Kg reduced the reactivity of animals in both phases being more efficient in the second stage 84.78%, the effect being partially reversed by naloxone. In the tail flick test used an opioid agonist and OR30-1000mg/Kg v.o), only the highest dose of 1g/kg (8100 ? 0.5489) increased the time of withdrawal of the tail significantly the stimulus in relation to their vehicle controls (5300 ? 0.3697) and fentanyl (17.80 ? 2023) at the time of evaluation, however not as much as the reference drug. The OR 300mg/kg was shown to have antinociceptive effect by increasing the time to remove the tail and when administered to group pre-treated with p-clorophenilalanina (PCPA100mg/kg ip), reversed the hyperalgesic effect. In assessing anti-inflammatory, pretreatment with increasing doses of OR (10-1000mg/Kg) inhibited dose-dependently and significantly the formation of ear edema induced by croton oil in 79.95%, ID50 calculed 321,34mg/kg, and this activity antiedematogenic shows one more anti-inflammatory property of this OR. In pleurisy test, the pre-treatment with OR (1000mg/Kg acid, and acid kaurenoic 10mg/Kg polialtico 20mg/kg, vo), was able to reduce the number of leukocytes migrate into the pleural cavity at 59.80%, 49.13% and 54.34% respectively, while dexamethasone inhibited 66.64% compared to controls, thereby enhancing these results, anti-inflammatory properties of OR and this inhibition can be at least partly attributed to the activity of these two acids diterpene contained in the OR. Evaluating the action of OR on motor activity and CNS was observed that the OR 300mg/kg had an effect similar to the reference drug diazepam reducing the distance traveled, time of grooming and rearing and increased time in the central and immobility in open-field test a possible mechanism featuring anseolitic and sedative. In addition, the tail suspension test animals pretreated with PCPA, immobility time was significantly higher than in control groups and when received treatment with OR the immobility time of the animal returned to the level of controls showing a possible antidepressant activity of this mixture. Keywords: Copaifera glycycarpa, antinociceptive, anti-inflammatory diterpenes
publishDate 2012
dc.date.issued.fl_str_mv 2012-08-20
dc.date.accessioned.fl_str_mv 2020-06-23T23:33:10Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Marissa Figueiredo. Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke). 2012. 86 f. Disserta??o (Mestrado Multic?ntrico em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
dc.identifier.uri.fl_str_mv https://tede.ufrrj.br/jspui/handle/jspui/3664
identifier_str_mv CARVALHO, Marissa Figueiredo. Atividade antinociceptiva e anti-inflamat?ria da ?leo-resina da Copaifera Glycycarpa (Ducke). 2012. 86 f. Disserta??o (Mestrado Multic?ntrico em Ci?ncias Fisiol?gicas) - Instituto de Ci?ncias Biol?gicas e da Sa?de, Universidade Federal Rural do Rio de Janeiro, Serop?dica, 2012.
url https://tede.ufrrj.br/jspui/handle/jspui/3664
dc.language.iso.fl_str_mv por
language por
dc.relation.references.por.fl_str_mv ABBAS, A.K., LICHTMAN, A.H. In: Imunologia celular a molecular. Ed, Elsevier quinta edi??o, 2005. AHUMADA, C.; SAENZ, T.; GARCIA, D.; DeLa PUERTA, R.; FERNANDEZ, A. e MARTINEZ, E. The effects of a triterpene fraction isolated from Crataegus monogyna Jacq. on different acute inflammation models in rats and mice. Leucocyte migration and phospholipase A2 inhibition. Journal of Pharmacology. V.49 (3), p.329-331, 1997. AIRES, M. M. e Colabodores ,RJ. Fisiologia. 2008. 3.ed., Rio de Janeiro: Guanabara Koogan p.242-57. ALVES, T. M. A.; CHAVES, P. P. G.; SANTOS, L. M. S. T.; NAGEM, T. J.; MURTA, S. M. F.; CERAVOLO, I. P.; ROMANHA, A. J.; ZANI, C. L. Planta M?dica. V.61, p.85, 1995. APPLETON, I.; TOMLINSON, A.; WILLOUGHBY, D. A. Induction cyclo-oxygenase and nitric oxide synthase in inflammation. Advances in Pharmacology. v.35, p.27?78, 1996. APPOLIN?RIO, P. P.; DEROGIS, P. B. M. C.; YAMAGUTI, T. H.; MIYAMOTO, S. Metabolismo, oxida??o e implica??es biol?gicas do ?cido docosahexaenoico em doen?as neurovegetativas Quimica Nova, v.43, p.1-8, 2011. ARCHER, J. Tests for emotionality in rats and mice: a review. Animal Behavior v.21 (2), p.205-235, 1973. ASHMAWI, H. A.; BRAUN, L. M.; SOUSA, A. M.; POSSO, I. P. Analgesic Effects of H1 Receptor Antagonists in the Rat Model of Formalin-Induced Pain. Revista Brasileira de Anestesioliologia v.59, p.461-70, 2009. BASILE, A. C.; SERTI?, J. A.; FREITAS, P.C. D.; ZANINI, A. C. Anti.inflammatory activity ofoilresin from Brazilian Copaifera. Jornal of Ethnopharmacology v.22, p.101-109, 1988. BHATIA, M.; WONG, F. L.; CAO, Y.; LAU, H. Y.; HUANG, J.; PUNEET, P. Pathophysiology of acute pancreatitis. Pancreatology. v.5, p.132?44, 2005. BOLLER, S.; SOLDI, C.; MARQUES, M. C. A.; SANTOS, E. P.; CABRINI, D. A.; PIZZOLATTI, M. G.; ZAMPRONIO, A. R.; OTUKI, M. F. Anti-inflamatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. Journal of Ethnophamacology. v.130, p.262-266, 2010. BOISSIER, J. R. e SIMON, P. The exploration reaction in the mouse. Preliminary note. Th?rapie. v.17, p.1225-1232, 1962. BREYER, R. M.; BAGDASSARIAN, C. K.; MYERS, S. A.; BREYER, M. D. Prostanoid receptors: Subtypes and signaling. Annual Review of Pharmacology and Toxicology. v.41, p. 661-90, 2001. BUCHANAN, F. G.; CHANG, W.; SHENG, H.; SHAO, J.; MORROW, J. D. DUBOIS, R. N. Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor. Gastroenterology. v.127, n?5, p.1391?400, 2004. BUT, P. G.; MURAVEV, R. A.; FORMINA, V. A.; ROGOVIN, V. V. Antimicrobial activity of myeloperoxidase from neutrophilic peroxisome. Biological Bulletin. v.29, p.212-15, 2002. CARVALHO, W. A.; LEM?NICA, L. Mecanismos centrais de transmiss?o e de modula??o da dor. Atualiza??o terap?utica. Revista Brasileira de Anestesiologia. v.48, p.221 ? 41, 1998. CASCON, V.; GILBERT, B. Characterization of the Chemical Composition of Oilresins of Copaifera guyanensis Desf., Copaifera duckei Dwyer and Copaifera multijuga Hayne.Phytochemistry. v.55 (7), p.773-778, 2000. CAWTHORN, W. P.; SETHI, J. K. TNF-alpha and adipocyte biology. FEBS Letters. v.582, p.117-31, 2008. CHANDRASEKHARAN, N. V.; DAI, H.; ROOS, K. L.; EVANSON, N. K.; TOMSIK, J. ELTON, T. S. SIMMONS, D. L. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proceedings of National Academy of Sciences USA. v.99, , p.13926?31, 2002. CHARLESWORTH, E. N.; KAGEY-SOBOTKA, A.; SCHLEIMERr, R. P.; NORMAN, P. S.; LICHTENSTEIN, L. M. Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen. The Journal of Immunology v.146, p. 671?76, 1991. CHENG, H. F.; HARRIS, R. C. Cyclooxygenases, the kidney, and hypertension. Hypertension. v.43, p.525?30, 2004. CHOI, R. J.; SHIN, E. M.; JUNG, H. A.; CHOI, J. A.; KIM, Y. S.Inhibitory effects o kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages Phytomedicine v.18; p.677?682, 2011. CLOEZl-TAYARANI, I.; CHANGEUX, J. P. Nicotine and serotonin in immune regulation and inflammatory processes: a perspective. Journal Leukocyte Biology. v.81, p.599?606, 2007. COGGESHALL R.E.; CARLTON, S.M. Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Research Review v.24, p. 28-66, 1997. COSTA, R. Effect of novel selective non-peptide kinin B(1) receptor antagonists on mouse pleurisy induced by carrageenan. Peptides. v. 27, p.2967-75, 2006. CUNHA, K. M. A.; PAIVA, L. A. F; SANTOS F. A; GRAMOSA. N. V; SILVEIRA E. R; RAO, V. S. N Smooth muscle relaxant effect of kaurenoic acid diterpene from copaifera langsdorffii on rat uterus in vitro.Phytotherapy Research.v.17, 2002. CRYAN, J. F.; MOMBEREAU, C.; VASSOUT A. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neuroscience and Behavoral Reviews, 29, p. 571?625, 2005. CURIO, M.; JACONE, H.; PERRUT, J.; PINTO, A. C.; VEIGA FILHO, V. F.; SILVA, R. C. B. Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. DI STASI, L.C. Plana medicinas:Verdades e mentiras.S?o Paulo:Unesp, 2007, p.10-83 DJAHANGUIRI, B. The production of acute gastric ulceration by indomethacin in the rat. Scand. Journal of. Gastroenterology. v.4, p.265-267, 1969. DUBUISSON, D.; DENNIS, S. G. The formalin test:a quantitative study of the analgesic effects of morphine,meperidine,and brain stem stimulation in rats and cats.Pain. v.4,p.161-1174,1977. DUHAM, N. W. e MYIA, T. S. Journal of. American Pharmacology Association. 46, 208, 1957. DWYER, J.D.The Central American West Indian and South American Species of Copaifera (Caesalpiniacea).Brittonia. v.7(3), p.143-172, 1951. FERNANDES, R. M.; PEREIRA, N. A.; PAULO, L. G. Antinflammatory activity of copa?ba balsam(Copaifera Cearensis Huber). Revista Brasileira de Farm?cia. v.73, p.53-56, 1992. GAO, W.; SCHMIDTKO, A.; WOBST, I.; LU, R.; ANGIONI, C.; GEISSLINGER, G. Postaglandin D2 Produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. Journal of Physiology and Pharmacology. v.60, p.145-50, 2009. GAUT, J. P.; YEH, G. C.; TRAN, H. D.; BYUN, J.; HENDERSON, J. P.; RICHTER, G. M.; BRENNAN, M. L.; LUSIS, A. J.; BELAAOUA, A.; HOTCHKISS, R. S.; HEINECKE, J. W. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proceedings of National Academy of Sciences . v.98, p.11961-66, 2001. GIBSON, S. J.; POLAK, J. M.; BLOOM, S. R.; SABATE, I. M.; MULDERRY, P. M.; GHATEI, M. A.; MCGREGOR, G. P.; MORRISON, J. F.; KELLY, J. S.; EVANS, R. M.; ROSENFELD, M. G. Calcitonin-gene related peptide immunoreactivity in the spinal cord of man and eight other species. Journal os Neuroscience. v.4, p.3101? 11, 1984. GIORDANO, J. The Neurobiology of Nociceptive and Anti-nociceptive Systems. Pain Physician v.8, p.277- 90, 2005. GOMES, N. M.; REZENDE ,C. M.; FONTES ,S. P.; MATHEUS, M. E.; FERNANDES, P. D. Antinociceptive activity of Amazonian Copaiba oils. Journal of Ethnopharmacology . v.109, p.486-492, 2007. GOMES, N. M.; REZENDE ,C. M.; FONTES ,S. P.; MATHEUS, M. E.; PINTO, A. C. e FERNANDES, P. D. Characterization f the antinociceptive and antinflammatory activities of fractions obtained from Copaifera multijuga Hayne Journal of Ethnopharmacology v.128, p.177-183, 2010. HARGREAVES, K.; DUBNER, R.; BROWN, F.; FLORES, C.; JORIS, J. A new and sensitive method for measuring thermal nociception in cutaneos hyperalgesia.Pain.v.32 n.1, p.77-78, 1988. HESS, S .; PADOANI, C.; SCORTEGANHA, L. C.; HOLZMANN, I.; MALHEIROS, A. YUNES, R. A.; MONACHE, F. D.; SOUZA, M. M. Assemment of mechanisms involved in Antinoception Caused by Myrsinoic Acid B Biological and Pharmaceutical Bulletim v.33(2), p.209-215, 2010 HILL, S. J.; GANELLIN, C. R.; TIMMERMAN H.; SCHWARTZ, J. C.; SHANKLEY, N. P.; YOUNG, J. M.; SCHUNACK, W.; LEVI, R.; HASS, H. L. International Union of Pharmacology. XIII. Classification of Histamine Receptors. Pharmacology Research. v.49, p.253-78, 1997. HONG, Y.; JI, H.; WEI, H. Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. Pain. v.124, p. 27?33, 2006. HOYER, D.; HANNON, J. P.; MARTIN, G. R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav. v.71, p.533?54, 2002. HUSSAIN, T.; GUPTA, S.; MUKHTAR, H. Cyclooxygenase-2 and prostate carcinogenesis. Cancer Lett. v.191, p.125-35, 2003. HUNSKAAR, S.; FASMER, O. B.; e HOLE, K. Dissociation between antinociceptive and anti-inflamatory effects of acetylsalicylic acid and indomethacin in the formalin test. Journal of Neuroscience. Meth. 14, 69, 1986. HUNSKAAR, S. and HOLE, K. Formalin test in mice: dissociation between antinflammatory and non-inflammatory pain. Pain v.30, p.103-114, 1987. JONES, T. C.; HUNT, R. D.; KING, N. W. Patologia Veterin?ria. 2000. S?o Paulo: Manole JULIUS, D.; BASBAUM, A. I. Molecular mechanisms of nociception. Nature v.413, p203?10, 2001. KALKAN, A.; BULUT, V.; EREL, O.; AVCI, S.; BINGOL, N. K. Adenosine deaminase and guanosine deaminase activities in sera of patients with viral hepatitis.Mem?rias do Instituto Oswaldo Cruz v.94, p.383?6, 1999. KANAOKA, Y.; URADE, Y. Hematopoietic prostaglandin D synthase. Prostaglandins Leukotrienes and Essential Fatty Acids v.69, p.163-7, 2003. KIS, B.; SNIPES, J. A.; ISSE, T.; NAGY, K.; BUSIJA, D. W. Putative cyclooxygenase-3 expression in rat brain cells. Journal of Cerebral Blood Flow and Metabolism. v.23, p.1287?92, 2003. KIS, B.; SNIPES, J. A.; BUSIJA, D. W. Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. Journal Pharmacology Experimental Therapies. v.315, p.1412-14, 2005. KLAUMAN, P. R.; WOUK, A. F. P. F.; SILAS, T. Patofisiologia da dor. Archives of Veterinary Science v.13, p.1-12, 2008. KOSTER,R.; ANDERSON, M.; DE BEER, E. J. Acetic acid for analgesic screening.Federation Proceedings. v.18, p.412 ,1959. KUMAR, V.; ABBAS, A. K.; FAUSTO, N.; ASTER, J. C. ROBBINS and COTRAN-Patologic Basis of Disease, 8th editon, 2010, Elsevier. KURUMBAIL, R. G.; KIEFER, J. R.; MARNETTT, L. J. cyclooxygenase enzymes: catalysis and inhibition. Current Opinion in Structural Biology. v.11, p.752-60, 2001. KUSHNIR-SUKHOV NM, BROWN JM, WU Y, KIRSHENBAUM A, METCALFE DD. Human mast cells are capable of serotonin synthesis and release. Journal of Allergy and Clinical Immunology. v.119(2), p.498?499, 2007. LIM, H.; JUNG, H. A.; CHOI, J. S.; KIM, Y. S.; KANG, S. S.; KIM, H. P. Anti-inflammatory activity of the constituents of the roots of Aralia continentalis Archives of Pharmacological Research v.32, p.1237-1243, 2009 LIMA, S.R.M.; VEIGA, J.R.V.F.;.CHRISTO, H.B.; PINTO, A.C.; FERNANDES, P.D.In vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions.Phytotherapy Research. v.17, p.1048-1053,2003. LIMA, A. RJ. ?ndice Terap?utico Fitoter?pico. 2008. 1 ed.-Petr?polis:EPUB LOCKSLEY, R. M.; KILLEEN, N.; LENARDO, M. J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell v.104, p.487?501, 2001. MACIEL, M.A.M.; PINTO, A.C.; VEIGA JUNIOR, V.F; GRYNBERG, N.F.; ECHEVARRIA, A. Plantas Medicinais:A Necessidade de Estudos Multidisciplinares. Quimica Nova. v.25, n.3, 2002. MAGGI, C. A. Tachykinins and calcitonin gene-related peptide (CGRP) as cotransmitters released from peripheral endings of sensory nerves. Progress in Neurobiology. v.45, p.1-98, 1995. MARTINS-DA-SILVA, R.C.V; PEREIRA, J.F. e LIMA, H.C. O g?nero Copaifera (Leguminosae ? Caesalopinoideae) na Amaz?nia Brasileira.Rodriguesia. v. 59(3), p.455-476, 2008. MIYAZAWA, M.; SHIMAMURA, H.; NAKAMURA, S.; KAMEOKAT,H. Antimutagenic Activity of(+)- Polyalthic Acid from Vitex Rotundiforia Journal of. Agricultural and. Food Chemmistry. v. 43, p.3012-3015, 1995. MELZACK, R.; WALL, P. D. Pain mechanisms: a new theory. Science. v.150, p.971?79, 1965. MESSLINGER, K. What is a nociceptor ? Anaesthesistogy. v.46, p.142-53, 1997. MERSKEY, H.; BOGDUK, N. Classification of chronic pain. Seattle: IASP Press. 1994. MILLAN, M. J. The induction of pain: an integrative review. Progress in Neurobiology v.57, p.1?164, 1999. MILLAN, M. J. Descending control of pain. Progress in Neurobiology v.66, p.355?474, 2002. MURAKAMI, M..; NAKASHIMA, K.; KAMEI, D.; MASUDA, S.; ISHIKAWA, Y.; ISHII, T.; OHMIYA, Y.; WATANABE, K.; KUDO I. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. The Journal of Biological Chemmistry. v.278, p.37937?47, 2002. NEVE, J.; PARIJ, N.; MOGUILEVSKY, N. Inhibition of the myeloperoxidase chlorinating activity by nonsteroidal anti-inflammatory drugs investigated with a human recombinant enzyme. European Journal of Pharmacology. v.417, p.37-43, 2001. PAIVA, L.A.F; RAO, V.S.N.; GRAMOSA, N.V.; SILVEIRA, E.R. Gastroprotective effect of Copaifera langsdorffii ?leo-resin on experimental gastric ulcer models in rats. Journal of Ethnopharmacology. 62 p.73-78, 1998. PAIVA, L.A.F.; GURGEL, L.A.; SILVA, R.M.; TOM?A.R.; GRAMOSA, N.V.; SILVEIRA, E.R.; SANTOS, F.A.; RAO, V.S.N. Anti-inflammatory effects of Kaurenoic acid,a diterpene from copaifera langsdorffii on acetic acid-induced colitis in rats. Vascular pharmacology. v.39, p.303-307, 2003. PAIVA, L. A. F.; GURGEL, L. A.; DE SOUZA, E. T.; SILVEIRA, E. R.; SILVA, R. M.; SANTOS, F. A.; RAO, V. S. N Protective effet of Copaifera langsdorffii oil-resin against acetic-acid-induced colitis in rats. Journal of Ethonopharmacology v.93, p.51-56, 2004 PEREIRA, F.J.; MARTINS, F. T.; CORR?A, R.S.; MOREIRA, M.E.C.; COSTA, A.M.D.D.; DOS SANTOS, M.H.; POLO, M.; BARBOSA, L.C.A. Isolamento, Composi??o Qu?mica e Atividade Anti-inflamat?ria do ?leo Essencial do Pericarpo de Copaifera langsdorffii Desf.de acordo com Hidrodestila??es sucessivas Latin American Journal of Pharmacy v.27(3), p.369-374, 2008. PICOT, D.; LOLL, P. J.; GARAVIT, R. M. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature v.367, p.243-9, 1994. PIERI, F.A.; MUSSI, M.C.; MOREIRA, M.A.S. ?lo de copa?ba (Copaifera sp.): hist?rico, extra??o, aplica??es industriais e propriedades medicinais. Revista Brasileira de Plantas Medicinais (Botucatu) v.11, p.465-472, 2009. PINHEIRO, M M.; BESSA, S. O.; FINGOLO, C. E.; KUSTER, R. M.; MATHEUS, M. E.; MENEZES, F. S. E FERNANDES, P. D.Antinociceptive activity of fractions from Couroupita guianensis Albl. Leaves Journal of Ethnopharmacology. v.127(2), p.407-413, 2010. RAFFA, R. B. Antihistamines as analgesics. Journal of Clinical Pharmacology Therapies. v.26, p.81-5, 2001. RANG, H.P.; DALE, M.M.; RITTER, J.M.; FLOWERS, RJ.Farmacologia.2007.6 ed.,Rio de Janeiro:Elsevier. REYES-TREJO, B.; S?NCHEZ-MENDONZA, M.E.; BECERRA-GARCIA, A.A; CEDILLO-PORTUGAL, E.; CASTILLO-HENKEL, C.; ARRIETA, J. Bioassay-guided isolation of an anti-ulcer diterpenoid from Croton reflexifolius: role of nitric oxide, prostaglandins and sulfhydryls. Journal of pharmacy and pharmacology v.60, p. 931?936, 2008 ROSEN, H.; MICHEL, B. Redundant contribution of myeloperoxidase dependent systems to neutrophilmediated killing of Escherichia coli. Infection and Immunity. v.65, p.4173?8, 1997. SACHETTI, C.G.; FASCINELI, M.L.; SAMPAIO, J.A.; LAMEIRA,O.A.; CALDAS, E.D. Avalia??o da toxicidade aguda e potencial neurot?xico do ?leo-resina de copa?ba (Copaifera reticulata Ducke, Fabaceae) Revista Brasileira de Farmacognosia v.19(4), p. 937-941, 2009 SALEH, T. S. F.; CALIXTO, J. B.; MEDEIROS, Y. S. Pro-inflammatory effects induced by bradikinin in a murine model of pleurisy. European Journal of Pharmacology. v.331, p.43-52, 1997. SCHIANTARELLI, P.; CADEL, S.; ACERBI, D. e PAVESI, L. Antiinflammatory activity and bioavailability of percutaneous piroxicam. Arzneim.-Forsch./Drug Research. v.32 (3), p.230-235, 1982. SERHAN, C.N.; SAVILL, J. Resolution of Inflammation: The beginning programs the end Nature Immunology . v. 6, p.1191-1197, 2005. SERHAN, C.N. Nuevos mediadores qu?micos en la resoluci?n de la inflamaci?n: resolvinas y protectinas Anesthesiology Clinics of North America v.24, p.341-364, 2006. SKILL, N. J.; THEODORAKIS, N. G.; WANG, Y. N.; WU, J. M.; REDMOND, E. M.; Sitzmann, J. V. Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension. American Journal of Gastrointestinal and Liver Physiology. v.295, p.53-64, 2008. SOUZA, P.A.; RANGEL, L. P.; OIGMAN, S. S.; ELIAS, M. M.; FERREIRA-PEREIRA, A.; GARDEN, N. C. L. e LEIT?O, G. G. The Efficient Preparative Isolation of Two Bioactive Diterpenic Acids from Copaifera glycycarpa Ducke Oilresin by High-Speed Counter-Current Chromatography (HSCCC) Using a Non-aqueous Solvent System. Phytochemical Analysis.v.21; p.539-543, 2010. STERU, L.;CHERMAT, R.;THIERRY ,B.; SIMON, P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology V.85(3), p.367-370, 1985. TAPPIN, M. R. R.; PEREIRA, JISLAINE F .G.; LIMA, L. A.; SIANI, A. C.; MAZZEI, J. L.; RAMOS, M. F. S. An?lise qu?mica quantitativa para padroniza??o do ?leo de copa?ba por cromatografia em fase gasosa de alta resolu??o. Qu?mica Nova. v.27, p.236-240, 2004. TINCUSI, B.M.; JIMENEZ, I.A.; BAZZOCCHI, I.L.; MOUJIR, L.M.; MAMANI, Z.A; BARROSO, J.P.; RAVELO, A.G.; HERNANDEZ, B.V. Antimicrobial terpenoids from the oleoresin of the peruvian medicinal plant Copaifera paupera. Planta M?dica. v. 68, p.808-812, 2002. VEIGA JUNIOR V.F.; PATITUCCI, M.L. ; PINTO, A.C. Controle de Autenticidade de ?leos de copa?ba comerciais por cromatografia gasosa de alta resolu??o Qu?mica Nova.v.20, p.612, 1997. VEIGA JUNIOR V. F.; ZUNINO, L.; CALIXTO, J. B.; PATITUCCI, M. L.; PINTO ,A. C. Phytochemical and antiedematogenic studies of comercial copa?ba oil avaible in Brazil.Phytotherapy research. v.15, p.476-480, 2001. VEIGA JUNIOR,V.F.; PINTO,A.C.; O G?nero Copaifera L. Qu?mica Nova.v.25, p.273-286, 2002. VEIGA JUNIOR, V. F.; ROSAS, E. C.; CARVALHO, M. V.; HENRIQUES, M. G. M. O.; PINTO, A. C. Chemical composition and anti-inflamatory activity of copaiba oils from Copaifera cearensis Huber (ex Ducke), Copaifera reticulata Ducke and Copaifera multijuga Hayne ? A comparative study. Journal of Ethnopharmacology. v.112, p.248-254, 2007. VEIGA JUNIOR,V.F.; LEANDRO, L.M.; VARGAS, F.S.; BARBOSA, P.C.S.; NEVES, J.K.O.; SILVA, J.A.; Chemistry and Biological Activities of Terpenois from copaiba (Copaifera spp) Oilresins. Molecules v.17, p. 3866-3889, 2012. VIEIRA, R.C.; BOMBARDIERE, E.; OLIVEIRA, J.J.; LINO-JUNIOR,R.S. BRITO,L.A.B.; JUNQUEIRA-KIPNIS,A.P. INFLU?NCIA DO ?LEO DE Copaifera langsdorffii NO REPARO DE FERIDA CIR?RGICA NA PRESEN?A DE UM CORPO ESTRANHO) Pesquisa Veterin?ria Brasileira. V.28 (8) p.358-366, 2008 WINKELSTEIN, B. A. Mechanisms of central sensitization, neuroimmunology & injury biomechanics in persistent pain: implications for musculoskeletal disorders. Journal of Electromyography and Kinesiology. v.14, p. 87-93,2004. WOOLFE, G. and MACDONALD, A. D. The evaluation of analgesic action of pethidine hydrochloride (DEMEROL) . Jounal of Pharmacology Experimental Therapies. v. 80, p. 300-307, 1944. WOOLF, C.J. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann. Intern. Med v. 140, n. 6, p. 441- 451, 2004. YU, B.; BECNEL, J.; ZERFAOUI, M.; ROHATGI, R.; BOLARES, A. H.; NICHOLS, C. D. Serotonin 5-Hydroxytryptamine 2A Receptor Activation Suppresses Tumor Necrosis Factor-Induced Inflammation with Extraordinary Potency. Journal of Pharmacology Experimental Therapies. v.327, p.316-23, 2008. ZIMMERMANN, M. Ethical considerations in relation to pain in animal experimentation. Acta Physiologica Scandinavica Supplement.v.554, p.221-233, 1986.
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dc.publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
dc.publisher.program.fl_str_mv Programa Multic?ntrico de P?s-Gradua??o em Ci?ncias Fisiol?gicas
dc.publisher.initials.fl_str_mv UFRRJ
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Instituto de Ci?ncias Biol?gicas e da Sa?de
publisher.none.fl_str_mv Universidade Federal Rural do Rio de Janeiro
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ
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